中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
20期
37-39,43
,共4页
连续性静脉-静脉血液滤过%多发性损伤%全身炎性反应综合征
連續性靜脈-靜脈血液濾過%多髮性損傷%全身炎性反應綜閤徵
련속성정맥-정맥혈액려과%다발성손상%전신염성반응종합정
Continuous venovenous hemofiltration%Multiple trauma%Systemic inflammatory response syndrome
目的：探讨连续性静脉-静脉血液滤过(CVVH)治疗重症多发性创伤(SMI)导致的多器官功能障碍综合征的临床效果。方法选取本院2011年1月~2014年1月收治的100例重症多发性创伤患者作为研究对象，随机分为对照组和观察组，各50例。对照组给予常规综合治疗，观察组在对照组的基础上采用CVVH治疗。观察两组治疗前后的肌酐(SCr)、尿素氮(BUN)、K+、Na+和HCO3-水平，并比较两组治疗前后的APACHE Ⅱ、MODS和SOFA评分。结果观察组治疗后的SCr、BUN、K+、Na+水平显著低于对照组治疗后，HCO3-水平显著高于对照组治疗后，差异有统计学意义(P<0.05)。观察组治疗后的APACHEⅡ、MODS及SOFA评分显著低于对照组，差异有统计学意义(P<0.05)。观察组的病死率显著低于对照组，差异有统计学意义(P<0.05)。结论 CVVH可通过下调炎症介质而调控机体的炎性反应，能够明显改善机体内各脏器组织的生理学功能。
目的：探討連續性靜脈-靜脈血液濾過(CVVH)治療重癥多髮性創傷(SMI)導緻的多器官功能障礙綜閤徵的臨床效果。方法選取本院2011年1月~2014年1月收治的100例重癥多髮性創傷患者作為研究對象，隨機分為對照組和觀察組，各50例。對照組給予常規綜閤治療，觀察組在對照組的基礎上採用CVVH治療。觀察兩組治療前後的肌酐(SCr)、尿素氮(BUN)、K+、Na+和HCO3-水平，併比較兩組治療前後的APACHE Ⅱ、MODS和SOFA評分。結果觀察組治療後的SCr、BUN、K+、Na+水平顯著低于對照組治療後，HCO3-水平顯著高于對照組治療後，差異有統計學意義(P<0.05)。觀察組治療後的APACHEⅡ、MODS及SOFA評分顯著低于對照組，差異有統計學意義(P<0.05)。觀察組的病死率顯著低于對照組，差異有統計學意義(P<0.05)。結論 CVVH可通過下調炎癥介質而調控機體的炎性反應，能夠明顯改善機體內各髒器組織的生理學功能。
목적：탐토련속성정맥-정맥혈액려과(CVVH)치료중증다발성창상(SMI)도치적다기관공능장애종합정적림상효과。방법선취본원2011년1월~2014년1월수치적100례중증다발성창상환자작위연구대상，수궤분위대조조화관찰조，각50례。대조조급여상규종합치료，관찰조재대조조적기출상채용CVVH치료。관찰량조치료전후적기항(SCr)、뇨소담(BUN)、K+、Na+화HCO3-수평，병비교량조치료전후적APACHE Ⅱ、MODS화SOFA평분。결과관찰조치료후적SCr、BUN、K+、Na+수평현저저우대조조치료후，HCO3-수평현저고우대조조치료후，차이유통계학의의(P<0.05)。관찰조치료후적APACHEⅡ、MODS급SOFA평분현저저우대조조，차이유통계학의의(P<0.05)。관찰조적병사솔현저저우대조조，차이유통계학의의(P<0.05)。결론 CVVH가통과하조염증개질이조공궤체적염성반응，능구명현개선궤체내각장기조직적생이학공능。
Objective To explore the clinical effect of continuous venovenous hemofiltration (CVVH) in the treatment of multiple organ dysfunction syndrome caused by severe multiple trauma (SMI). Methods 100 cases with severe multiple trauma in our hospital from January 2011 to January 2014 were selected and randomly divided into the control group and the observation group according to different treatment methods,50 cases in each group.The control group was treat-ed with conventional treatment,the observation group was given CVVH treatment on the basis of the control group.The level of serum creatinine (SCr),urea nitrogen (BUN),K+,Na+and HCO3-in two groups before and after treatment was ob-served,and the score of APACHE II,MODS and SOFA in two groups before and after treatment was compared. Results The level of SCr,BUN,K+,Na+ in the observation group after treatment was lower than that in the control group after treatment,the level of HCO3- in the observation group after treatment was higher than that in the control group after treatment,with significant difference (P<0.05).The score of APACHEII,MODS and SOFA in the observation group after treatment was lower than that in the control group after treatment,with significant difference (P<0.05).The mortality rate in the observation group was lower than that in the control group,with significant difference(P<0.05). Conclusion CVVH can significantly improve the physiological functions of the tissues and organs within the body by downregulating the inflammatory mediators and regulating the body inflammatory reaction.
