CAJ | 학술논문

目的：比较血液透析联合血液灌流与联合血液透析滤过治疗维持性血液透析患者皮肤瘙痒的效果。方法选取2013年6月~2014年6月本院收治的48例维持性血液透析伴皮肤瘙痒患者作为研究对象，随机分为观察组和对照组，各24例。观察组采用血液灌流联合血液透析治疗，对照组采用血液透析滤过联合血液透析治疗。比较两组治疗前后的皮肤瘙痒缓解程度以及血尿素氮(BUN)、肌酐(SCr)、血清钙(Ca2+)、血清磷(P3-)和血清甲状旁腺激素(PTH)水平。结果观察组的瘙痒总缓解率为87.5%，显著高于对照组的50.0%，差异有统计学意义(P<0.05)。观察组的Ca2+、P3-水平显著低于对照组，差异有统计学意义(P<0.05)。两组的BUN和SCr水平比较，差异无统计学意义(P>0.05)。观察组治疗后的PTH水平显著低于对照组，差异有统计学意义(P<0.05)。结论血液透析联合血液灌流治疗尿毒症皮肤瘙痒患者的效果显著优于血液透析联合血液透析滤过，值得临床推广应用。
목적：비교혈액투석연합혈액관류여연합혈액투석려과치료유지성혈액투석환자피부소양적효과。방법선취2013년6월~2014년6월본원수치적48례유지성혈액투석반피부소양환자작위연구대상，수궤분위관찰조화대조조，각24례。관찰조채용혈액관류연합혈액투석치료，대조조채용혈액투석려과연합혈액투석치료。비교량조치료전후적피부소양완해정도이급혈뇨소담(BUN)、기항(SCr)、혈청개(Ca2+)、혈청린(P3-)화혈청갑상방선격소(PTH)수평。결과관찰조적소양총완해솔위87.5%，현저고우대조조적50.0%，차이유통계학의의(P<0.05)。관찰조적Ca2+、P3-수평현저저우대조조，차이유통계학의의(P<0.05)。량조적BUN화SCr수평비교，차이무통계학의의(P>0.05)。관찰조치료후적PTH수평현저저우대조조，차이유통계학의의(P<0.05)。결론혈액투석연합혈액관류치료뇨독증피부소양환자적효과현저우우혈액투석연합혈액투석려과，치득림상추엄응용。
Objective To compare the effect of hemodialysis combined with hemoperfusion and hemodialysis combined with hemodiafiltration in the treatment of pruritus for patients receiving maintenance hemodialysis. Methods 48 pa-tients of maintenance hemodialysis combined with pruritus in our hospital from June 2013 to June 2014 were selected and randomly divided into the observation group and the control group,24 cases in each group.The observation group was given the therapy of hemoperfusion combined with hemodialysis,the control group was treated with hemodiafiltration combined with hemodialysis.The alleviation degree of pruritus before and after treatment,the level of BUN,SCr,Ca2+,P3-and PTH in two groups was compared respectively. Results The total alleviation rate of pruritus in the observation group was 82.5%,which was higher than 50.0% in the control group,with significant difference (P<0.05).The level of PTH in the observation group after treatment was lower than that in the control group,with significant difference (P<0.05).The level of Ca2+and P3-in the observation group was lower than that in the control group,with significant differ-ence(P<0.05).The level of BUN and SCr between two groups was not significantly different (P>0.05). Conclusion The effect of hemodialysis combined with hemoperfusion in the treatment of uremia complicated with pruritus is significantly better than that of hemodialysis combined with hemodiafiltration,it is worthy of clinical promotion and application.