国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2015年
8期
569-572
,共4页
张丙信%赵霞%贾喜花%陈雪%陈红%马秋双%张金库
張丙信%趙霞%賈喜花%陳雪%陳紅%馬鞦雙%張金庫
장병신%조하%가희화%진설%진홍%마추쌍%장금고
乳腺肿瘤%原癌基因蛋白质 c-bcl-2%Bax
乳腺腫瘤%原癌基因蛋白質 c-bcl-2%Bax
유선종류%원암기인단백질 c-bcl-2%Bax
Breast neoplasms%Proto-oncogene proteins c-bcl-2%Bax
目的探讨 Bcl-2和 Bax 蛋白在基底细胞样乳腺癌(BLBC)中的表达及意义。方法免疫组织化学法检测43例 BLBC、57例非基底细胞样乳腺癌(non-BLBC)、60例正常乳腺组织中 Bcl-2和Bax 蛋白的表达,分析其与患者生理病理的关系。结果Bcl-2在 BLBC 中的表达率为69.77%,高于non-BLBC 的43.86%(χ2=6.647,P =0.010)和正常乳腺组织的21.67%(χ2=23.831,P =0.001);Bax在 BLBC 中的表达率为20.93%,低于 non-BLBC 的45.61%(χ2=6.564,P =0.010)和正常乳腺组织的76.67%(χ2=31.270,P =0.001)。Bcl-2和 Bax 在 BLBC 中的表达水平与淋巴结转移(χ2=6.927,P =0.008;χ2=6.203,P =0.013)及 pTNM分期(χ2=6.331,P =0.012;χ2=5.972,P =0.015)相关。Bcl-2与 Bax 在 BLBC 中的表达呈负相关(r =-0.408,P <0.010)。结论Bcl-2和 Bax 分别在 BLBC 中高表达和低表达,两者可能共同作用使细胞增殖与凋亡平衡失调,从而促进了 BLBC 的发生、发展。
目的探討 Bcl-2和 Bax 蛋白在基底細胞樣乳腺癌(BLBC)中的錶達及意義。方法免疫組織化學法檢測43例 BLBC、57例非基底細胞樣乳腺癌(non-BLBC)、60例正常乳腺組織中 Bcl-2和Bax 蛋白的錶達,分析其與患者生理病理的關繫。結果Bcl-2在 BLBC 中的錶達率為69.77%,高于non-BLBC 的43.86%(χ2=6.647,P =0.010)和正常乳腺組織的21.67%(χ2=23.831,P =0.001);Bax在 BLBC 中的錶達率為20.93%,低于 non-BLBC 的45.61%(χ2=6.564,P =0.010)和正常乳腺組織的76.67%(χ2=31.270,P =0.001)。Bcl-2和 Bax 在 BLBC 中的錶達水平與淋巴結轉移(χ2=6.927,P =0.008;χ2=6.203,P =0.013)及 pTNM分期(χ2=6.331,P =0.012;χ2=5.972,P =0.015)相關。Bcl-2與 Bax 在 BLBC 中的錶達呈負相關(r =-0.408,P <0.010)。結論Bcl-2和 Bax 分彆在 BLBC 中高錶達和低錶達,兩者可能共同作用使細胞增殖與凋亡平衡失調,從而促進瞭 BLBC 的髮生、髮展。
목적탐토 Bcl-2화 Bax 단백재기저세포양유선암(BLBC)중적표체급의의。방법면역조직화학법검측43례 BLBC、57례비기저세포양유선암(non-BLBC)、60례정상유선조직중 Bcl-2화Bax 단백적표체,분석기여환자생리병리적관계。결과Bcl-2재 BLBC 중적표체솔위69.77%,고우non-BLBC 적43.86%(χ2=6.647,P =0.010)화정상유선조직적21.67%(χ2=23.831,P =0.001);Bax재 BLBC 중적표체솔위20.93%,저우 non-BLBC 적45.61%(χ2=6.564,P =0.010)화정상유선조직적76.67%(χ2=31.270,P =0.001)。Bcl-2화 Bax 재 BLBC 중적표체수평여림파결전이(χ2=6.927,P =0.008;χ2=6.203,P =0.013)급 pTNM분기(χ2=6.331,P =0.012;χ2=5.972,P =0.015)상관。Bcl-2여 Bax 재 BLBC 중적표체정부상관(r =-0.408,P <0.010)。결론Bcl-2화 Bax 분별재 BLBC 중고표체화저표체,량자가능공동작용사세포증식여조망평형실조,종이촉진료 BLBC 적발생、발전。
Objective To investigate the expressions and significances of Bcl-2 and Bax in basal-like breast carcinoma (BLBC).Methods The expressions of Bcl-2 and Bax were detected in 43 cases of BLBC, 57 cases of non-BLBC and 60 cases of normal breast tissues by immunohistochemistry,and their relationships with physiological and pathological characteristics of patients were analysized.Results The positive rate of Bcl-2 in BLBC was 69.77%,higher than 43.86% in non-BLBC (χ2 =6.647,P =0.01 0)and 21 .67% in normal breast tissues (χ2 =23.831 ,P =0.001 ).The positive rate of Bax in BLBC was 20.93%,lower than 45.61 % in non-BLBC (χ2 =6.564,P =0.01 0)and 76.67% in normal breast tissues (χ2 =31 .270,P =0.001 ).The expressions of Bcl-2 and Bax were correlated with lymphnode metastasis (χ2 =6.927,P =0.008;χ2 =6.203,P =0.01 3)and pTNMstaging of BLBC (χ2 =6.331 ,P =0.01 2;χ2 =5.972,P =0.01 5).There was negative correlation between the expression of Bcl-2 and Bax in BLBC (r = -0.408,P <0.01 0). Conclusion High expression of Bcl-2 and low expression of Bax interact with each other leading to unbalance of cell deferation and apoptosis,resulting in promoting genesis and progress of BLBC.