CAJ | 학술논문

目的研究 MMP-13、抑癌基因 p73在胃腺癌组织中的表达及其与临床病理参数的关系，评估其对胃腺癌转移预后的意义。方法应用免疫组织化学 SP 法检测 MMP-13、抑癌基因 p73在143例胃腺癌组织、55例癌旁正常组织中的表达情况，并分析其与临床病理参数的关系。结果胃腺癌组织中 MMP-13的表达显著高于癌旁组织（67．13％∶16．35％），差异有统计学意义（χ2＝41．10，P ＝0．000）；p73的表达也显著高于癌旁组织（58．74％∶12．73％），差异有统计学意义（χ2＝33．86，P ＝0．000）。胃腺癌中 MMP-13阳性表达与胃周围淋巴结转移（χ2＝11．835，P ＝0．001）、浸润深度（χ2＝5．177，P ＝0．032）、临床分期（χ2＝11．107，P ＝0．001）有关，而与患者年龄（χ2＝0．113，P ＝0．853）、肿瘤大小（χ2＝0．338，P ＝0．591）、癌细胞分化程度（χ2＝3．628，P ＝0．072）无关。胃腺癌中 p73阳性表达与胃周围淋巴结转移（χ2＝11．440，P ＝0．001）、癌细胞分化程度（χ2＝5．407，P ＝0．025）及临床分期有关（χ2＝9．497，P ＝0．003），而与患者年龄（χ2＝1．567，P ＝0．222）、肿瘤大小（χ2＝0．841，P ＝0．392）及浸润深度（χ2＝0．554，P ＝0．498）无关，二者在胃腺癌组织中的表达呈正相关（r ＝0．684，P ＝0．000）。结论MMP-13和 p73可能共同参与胃腺癌的发生发展过程，可作为评估胃腺癌浸润和转移的重要生物学指标。
목적연구 MMP-13、억암기인 p73재위선암조직중적표체급기여림상병리삼수적관계，평고기대위선암전이예후적의의。방법응용면역조직화학 SP 법검측 MMP-13、억암기인 p73재143례위선암조직、55례암방정상조직중적표체정황，병분석기여림상병리삼수적관계。결과위선암조직중 MMP-13적표체현저고우암방조직（67．13％∶16．35％），차이유통계학의의（χ2＝41．10，P ＝0．000）；p73적표체야현저고우암방조직（58．74％∶12．73％），차이유통계학의의（χ2＝33．86，P ＝0．000）。위선암중 MMP-13양성표체여위주위림파결전이（χ2＝11．835，P ＝0．001）、침윤심도（χ2＝5．177，P ＝0．032）、림상분기（χ2＝11．107，P ＝0．001）유관，이여환자년령（χ2＝0．113，P ＝0．853）、종류대소（χ2＝0．338，P ＝0．591）、암세포분화정도（χ2＝3．628，P ＝0．072）무관。위선암중 p73양성표체여위주위림파결전이（χ2＝11．440，P ＝0．001）、암세포분화정도（χ2＝5．407，P ＝0．025）급림상분기유관（χ2＝9．497，P ＝0．003），이여환자년령（χ2＝1．567，P ＝0．222）、종류대소（χ2＝0．841，P ＝0．392）급침윤심도（χ2＝0．554，P ＝0．498）무관，이자재위선암조직중적표체정정상관（r ＝0．684，P ＝0．000）。결론MMP-13화 p73가능공동삼여위선암적발생발전과정，가작위평고위선암침윤화전이적중요생물학지표。
Objective To study the expressions of matrix metalloproteinase-1 3 (MMP-1 3)and p73 in gastric adenocarcinoma,and to explore the associations of the expressions of MMP-1 3 and p73 with the clinico-pathological features,and to evaluate their clinical significances for the prognosis of gastric adenocarcinoma metastasis.Methods The immunohistochemistry SP methods was used to evaluate the expressions of MMP-1 3 and p73 in 1 43 cases of gastric adenocarcinoma and 55 normal tissues adjacent to carcinoma,and their associa-tions to the clinicopathologic features were analyzed.Results The expression of MMP-1 3 in gastric adenocarci-noma was significantly higher than that in adjacent tissues of cancer (67.1 3% vs 1 6.35%),with a significant difference (χ2 =41 .1 0,P =0.000).The expression of p73 in gastric adenocarcinoma was significantly higher than that in adjacent tissues of cancer (58.74% vs 1 2.73%),with a significant difference (χ2 =33.86,P =0.000).In the gastric adenocarcinoma,the expression of MMP-1 3 was associated with peripheral lymph node metastasis (χ2 =1 1 .835,P =0.001 ),depth of invasion (χ2 =5.1 77,P =0.032)and TNM stage (χ2 =1 1 .1 07,P =0.001 ),but it was not correlated with the ages of patients (χ2 =0.1 1 3,P =0.853),tumor size (χ2 =0.338,P =0.591 )and tumor differentiation level (χ2 =3.628,P =0.072).In the gastric adenocarci-noma,the expression of p73 was associated with peripheral lymph node metastasis (χ2 =1 1 .440,P =0.001 ), tumor differentiation level (χ2 =5.407,P =0.025)and TNMstage (χ2 =9.497,P =0.003),but it was not correlated with the ages of patients (χ2 =1 .567,P =0.222),tumor size (χ2 =0.841 ,P =0.392)and depth of invasion (χ2 =0.554,P =0.498).The expression of MMP-1 3 was positively correlated with the expression <br> of p73 in gastric adenocarcinoma group (r =0.684,P =0.000).Conclusion Both MMP-1 3 and p73 may participate in the development of gastric adenocarcinoma,which can be used as an important index for the eval-uation of invasiveness and metastasis in gastric adenocarcinoma.