国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2015年
16期
2371-2374
,共4页
付昕%马春玲%陈艳清%李婉葵%冯梅华
付昕%馬春玲%陳豔清%李婉葵%馮梅華
부흔%마춘령%진염청%리완규%풍매화
新鲜冰冻血浆%剂量%肝硬化腹水%疗效%不良反应
新鮮冰凍血漿%劑量%肝硬化腹水%療效%不良反應
신선빙동혈장%제량%간경화복수%료효%불량반응
Fresh frozen plasma%Dose%Ascites due to liver cirrhosis%Clinical curative effect%Adverse reaction
目的 观察不同剂量新鲜冰冻血浆(fresh frozen plasma,FFP)治疗肝硬化腹水的临床疗效与不良反应.方法 将90例符合纳入标准的肝硬化腹水患者随机分为FFP小剂量组(5 ml/kg)、中剂量组(10 ml/kg)和高剂量组(15 ml/kg),每组30例.三组均在统一治疗方案基础上输注不同剂量的FFP,疗程为2周.观察三组治疗前后凝血功能的变化、治疗后总体疗效及不良反应.结果 FFP小剂量组、中剂量组及高剂量组治疗后凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、国际标准化比值(INR)均下降,纤维蛋白原(FIB)均升高,但中剂量组及高剂量组疗效优于小剂量组(P＜0.05),中剂量组与高剂量组比较差异无统计学意义(P＞0.05).FFP小剂量组总有效率为53.33％,中剂量组为80.00％,高剂量组为83.33％.三组比较,中剂量组和高剂量组总有效率高于小剂量组(P＜0.05),中剂量组和高剂量组比较无统计学差异(P＞0.05).小剂量组和中剂量组未见明显不良反应,高剂量组出现1例轻度过敏反应及1例发热反应.结论 新鲜冰冻血浆治疗肝硬化腹水剂量为10 ml/kg时疗效优于5 ml/kg,且不良反应少.
目的 觀察不同劑量新鮮冰凍血漿(fresh frozen plasma,FFP)治療肝硬化腹水的臨床療效與不良反應.方法 將90例符閤納入標準的肝硬化腹水患者隨機分為FFP小劑量組(5 ml/kg)、中劑量組(10 ml/kg)和高劑量組(15 ml/kg),每組30例.三組均在統一治療方案基礎上輸註不同劑量的FFP,療程為2週.觀察三組治療前後凝血功能的變化、治療後總體療效及不良反應.結果 FFP小劑量組、中劑量組及高劑量組治療後凝血酶原時間(PT)、活化部分凝血酶時間(APTT)、國際標準化比值(INR)均下降,纖維蛋白原(FIB)均升高,但中劑量組及高劑量組療效優于小劑量組(P＜0.05),中劑量組與高劑量組比較差異無統計學意義(P＞0.05).FFP小劑量組總有效率為53.33％,中劑量組為80.00％,高劑量組為83.33％.三組比較,中劑量組和高劑量組總有效率高于小劑量組(P＜0.05),中劑量組和高劑量組比較無統計學差異(P＞0.05).小劑量組和中劑量組未見明顯不良反應,高劑量組齣現1例輕度過敏反應及1例髮熱反應.結論 新鮮冰凍血漿治療肝硬化腹水劑量為10 ml/kg時療效優于5 ml/kg,且不良反應少.
목적 관찰불동제량신선빙동혈장(fresh frozen plasma,FFP)치료간경화복수적림상료효여불량반응.방법 장90례부합납입표준적간경화복수환자수궤분위FFP소제량조(5 ml/kg)、중제량조(10 ml/kg)화고제량조(15 ml/kg),매조30례.삼조균재통일치료방안기출상수주불동제량적FFP,료정위2주.관찰삼조치료전후응혈공능적변화、치료후총체료효급불량반응.결과 FFP소제량조、중제량조급고제량조치료후응혈매원시간(PT)、활화부분응혈매시간(APTT)、국제표준화비치(INR)균하강,섬유단백원(FIB)균승고,단중제량조급고제량조료효우우소제량조(P＜0.05),중제량조여고제량조비교차이무통계학의의(P＞0.05).FFP소제량조총유효솔위53.33％,중제량조위80.00％,고제량조위83.33％.삼조비교,중제량조화고제량조총유효솔고우소제량조(P＜0.05),중제량조화고제량조비교무통계학차이(P＞0.05).소제량조화중제량조미견명현불량반응,고제량조출현1례경도과민반응급1례발열반응.결론 신선빙동혈장치료간경화복수제량위10 ml/kg시료효우우5 ml/kg,차불량반응소.
Objective To observe the clinical curative effect and adverse reaction of different doses of fresh frozen plasma (FFP) in the treatment of ascites due to liver cirrhosis.Methods 90 patients with ascites due to liver cirrhosis were randomly divided into low dose of FFP group (5 ml/kg),middle dose of FFP group (10 ml/ kg) and high dose of FFP group (15 ml/kg),30 cases in each group.Different doses of FFP were mainlined in three groups on the basis of a unified scheme.The course of treatment lasted 2 weeks.Blood coagulative function,the overall effect and adverse reaction were observed in three groups before and after treatment.Results After treatment,PT,APTT and INR decreased in all three groups,while FIB increased.Curative effect of middle dose group and high dose group were better than that of low dose group (P＜0.05),while there was no statistically significant difference in curative effect between middle dose group and high dose group (P＞0.05).The total effective rate was 53.33％ in low dose group,80.00％ in middle dose group,83.33％ in high dose group.The total effective rate of middle dose group and high dose group were better than that of low dose group,while there was no statistically significant difference in the total effective rate between middle dose group and high dose group.There was no obvious adverse reaction in low dose group or middle dose group;1 case of mild allergic reaction and 1 case of fever reaction occurred in high dose group.Conclusion FFP at the dose of 10 ml/kg was more effective than that at the dose of 5 ml/kg,with less adverse reaction.
