中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2015年
21期
35-38
,共4页
宋炜%李杰%庞海英%刘桂琴
宋煒%李傑%龐海英%劉桂琴
송위%리걸%방해영%류계금
绝经后女性%2型糖尿病%冠心病%危险因素
絕經後女性%2型糖尿病%冠心病%危險因素
절경후녀성%2형당뇨병%관심병%위험인소
Postmenopausal women%Type 2 Diabetes mellitus%Coronary heart disease%Risk factor
目的:探讨绝经后女性2型糖尿病(T2DM)合并冠心病的主要相关危险因素。方法选取2012年1月~2014年6月北京市大兴区红星医院内科住院的绝经后女性2型糖尿病患者335例,其中T2DM非合并冠心病组(无冠心病组)157例,T2DM合并冠心病组(冠心病组)178例。收集两组患者的临床资料;检测空腹血糖(FPG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及尿酸。结果冠心病组年龄、糖尿病病程明显高于无冠心病组(P<0.01);与无冠心病组比较,冠心病组的FPG、HbA1c、体重指数、收缩压、TC、LDL-C及TG均升高,HDL-C降低(P<0.05或P<0.01);冠心病组的患者高血压、肥胖、血脂紊乱、颈动脉斑块及脑卒中发病率均高于无冠心病组,差异均有统计学意义(P<0.05或P<0.01);冠心病阳性家族史显著高于无冠心病组(P<0.01)。 Logistic回归分析结果显示,年龄、病程、HbA1c、LDL-C及收缩压是T2DM合并冠心病的独立危险因素(OR值分别为1.21、1.08、1.49、1.11和1.03,P <0.05或 P <0.01)。结论年龄、糖尿病病程、HbA1c、LDL-C及收缩压与绝经后女性2型糖尿病合并冠心病的发病密切相关。
目的:探討絕經後女性2型糖尿病(T2DM)閤併冠心病的主要相關危險因素。方法選取2012年1月~2014年6月北京市大興區紅星醫院內科住院的絕經後女性2型糖尿病患者335例,其中T2DM非閤併冠心病組(無冠心病組)157例,T2DM閤併冠心病組(冠心病組)178例。收集兩組患者的臨床資料;檢測空腹血糖(FPG)、糖化血紅蛋白(HbA1c)、三酰甘油(TG)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)及尿痠。結果冠心病組年齡、糖尿病病程明顯高于無冠心病組(P<0.01);與無冠心病組比較,冠心病組的FPG、HbA1c、體重指數、收縮壓、TC、LDL-C及TG均升高,HDL-C降低(P<0.05或P<0.01);冠心病組的患者高血壓、肥胖、血脂紊亂、頸動脈斑塊及腦卒中髮病率均高于無冠心病組,差異均有統計學意義(P<0.05或P<0.01);冠心病暘性傢族史顯著高于無冠心病組(P<0.01)。 Logistic迴歸分析結果顯示,年齡、病程、HbA1c、LDL-C及收縮壓是T2DM閤併冠心病的獨立危險因素(OR值分彆為1.21、1.08、1.49、1.11和1.03,P <0.05或 P <0.01)。結論年齡、糖尿病病程、HbA1c、LDL-C及收縮壓與絕經後女性2型糖尿病閤併冠心病的髮病密切相關。
목적:탐토절경후녀성2형당뇨병(T2DM)합병관심병적주요상관위험인소。방법선취2012년1월~2014년6월북경시대흥구홍성의원내과주원적절경후녀성2형당뇨병환자335례,기중T2DM비합병관심병조(무관심병조)157례,T2DM합병관심병조(관심병조)178례。수집량조환자적림상자료;검측공복혈당(FPG)、당화혈홍단백(HbA1c)、삼선감유(TG)、총담고순(TC)、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)급뇨산。결과관심병조년령、당뇨병병정명현고우무관심병조(P<0.01);여무관심병조비교,관심병조적FPG、HbA1c、체중지수、수축압、TC、LDL-C급TG균승고,HDL-C강저(P<0.05혹P<0.01);관심병조적환자고혈압、비반、혈지문란、경동맥반괴급뇌졸중발병솔균고우무관심병조,차이균유통계학의의(P<0.05혹P<0.01);관심병양성가족사현저고우무관심병조(P<0.01)。 Logistic회귀분석결과현시,년령、병정、HbA1c、LDL-C급수축압시T2DM합병관심병적독립위험인소(OR치분별위1.21、1.08、1.49、1.11화1.03,P <0.05혹 P <0.01)。결론년령、당뇨병병정、HbA1c、LDL-C급수축압여절경후녀성2형당뇨병합병관심병적발병밀절상관。
Objective To investigate the related risk factors of type 2 diabetes mellitus (T2DM) combined with coronary heart disease (CHD) in postmenopausal women. Methods A total of 335 hospitalized postmenopausal women suffering from T2DM without CHD (non-CHD group, 157 cases) and with CHD (CHD group, 178 cases) were enrolled from Jan-uary 2012 to June 2014. Clinical data were collected and the levels of fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and blood uric acid (UA) were detected. Results Compared with the non-CHD group,the CHD group showed significantly greater age and longer duration of diabetes (P< 0.01). Further, the CHD group had higher levels of fasting blood glucose, glycosylated hemoglobin, BMI, systolic blood pressure, TC, LDL-C and TG, and lower level of HDL-C (P< 0.05 or P< 0.01). The incidences of hypertension, obesity, dyslipidemia, carotid artery plaque, cerebral stroke of CHD group were all higher than those of non-CHD group, the differences were statistically signifi-cant (P<0.05 or P<0.01). Logistic analysis showed that, age, duration of diabetes mellitus, HbA1c, LDL-C, and sys-tolic blood pressure were the independent risk factors of T2DM combined with coronary heart disease (OR=1.21, 1.11, 1.49, 1.08 and 1.03; P<0.05 or P<0.01). Conclusion Age, duration of diabetes mellitus, HbA1c, LDL-C, and systolic blood pressure are closely related to the incidence of type 2 diabetes mellitus combined with coronary heart disease in postmenopausal women.