CAJ | 학술논문

目的：探讨细胞因子 TNF-a、IL-6异常表达对输卵管性不孕患者的影响。方法：选取2012年9月至2013年8月因“不孕”在本院行腹腔镜手术治疗的病例45例作为视察组和因“子宫肌瘤及卵巢良性肿瘤”行腹腔镜手术患者47例作为对照组。采用酶联免疫法（ Elisa 法）测定两组患者腹腔液中TNF-a、IL-6水平。结果：对照组中 TNF-a、IL-6水平明显高于观察组（P﹤0.05）。结论：细胞因子 TNF-a、IL-6水平在输卵管性不孕患者中的表达异常升高，其细胞毒性可能导致输卵管性不孕发生。
목적：탐토세포인자 TNF-a、IL-6이상표체대수란관성불잉환자적영향。방법：선취2012년9월지2013년8월인“불잉”재본원행복강경수술치료적병례45례작위시찰조화인“자궁기류급란소량성종류”행복강경수술환자47례작위대조조。채용매련면역법（ Elisa 법）측정량조환자복강액중TNF-a、IL-6수평。결과：대조조중 TNF-a、IL-6수평명현고우관찰조（P﹤0.05）。결론：세포인자 TNF-a、IL-6수평재수란관성불잉환자중적표체이상승고，기세포독성가능도치수란관성불잉발생。
Objective:To investigate the effects of the abnormal expression of cytokines TNF-a and IL-6 in patients with tubal infertility. Methods: Forty-five patients with tubal infertility and 47 patients with hysteromyoma and benign ovarian tumor,who underwent laparoscopic surgery in our hospital between September 2012 and August 2013,were included in the study group and the control group,respectively. Enzyme-linked immuno sorbent assay(ELISA)was used to determine the levels of TNF-a and IL-6 in peritoneal fluid of the two groups. Results:The levels of cytokines TNF-aand IL-6 in the control group were significantly higher than those in the study group(P﹤0.05). Conclusion:The levels of cytokines TNF-a and IL-6 are abnormally high in patients with tubal infertility,and the cell toxicity may result in tubal infertility.