广州医科大学学报
廣州醫科大學學報
엄주의과대학학보
Academic Journal of Guangzhou Medical College
2015年
3期
57-60
,共4页
阻塞性睡眠呼吸暂停综合征%椎动脉病变%内皮素-1
阻塞性睡眠呼吸暫停綜閤徵%椎動脈病變%內皮素-1
조새성수면호흡잠정종합정%추동맥병변%내피소-1
obstructive sleep apnea-hypopnea syndrome%vertebral artery lesions%endothelin-1
目的：探讨阻塞性睡眠呼吸暂停综合征（OSAHS）与椎动脉狭窄、血浆内皮素-1（ET-1）之间的关系。方法：选择经多导睡眠监测仪检测，睡眠呼吸暂停低通气指数（AHI）≥5次/ h 的104例 OSAHS 患者与 AHI﹤5次/ h 的47例正常对照组患者作为研究对象，彩超检测患者椎动脉病变，酶联免疫反应测定血浆 ET-1水平。结果：OSAHS 组患者椎动脉狭窄发生率、斑块形成率明显高于对照组，分别为（29.8% vs 12.8%）、（26.9% vs 10.6%），差异有统计学意义（P﹤0.05）。AHI 与椎动脉 V1、V2段平均血管内径（Vd）呈负相关（r＝-0.31，P﹤0.05），与血浆 ET-1水平无显著相关（P＞0.05）。夜间最低动脉血氧（LSaO2）与 Vd 呈正相关，（r＝0.36），与 ET-1呈负相关（r＝-0.41），均 P﹤0.05。结论：OSAHS 患者椎动脉狭窄、粥样硬化斑块发生率增高；反复呼吸暂停、夜间缺氧引起血浆 ET-1升高可导致椎动脉损伤。
目的：探討阻塞性睡眠呼吸暫停綜閤徵（OSAHS）與椎動脈狹窄、血漿內皮素-1（ET-1）之間的關繫。方法：選擇經多導睡眠鑑測儀檢測，睡眠呼吸暫停低通氣指數（AHI）≥5次/ h 的104例 OSAHS 患者與 AHI﹤5次/ h 的47例正常對照組患者作為研究對象，綵超檢測患者椎動脈病變，酶聯免疫反應測定血漿 ET-1水平。結果：OSAHS 組患者椎動脈狹窄髮生率、斑塊形成率明顯高于對照組，分彆為（29.8% vs 12.8%）、（26.9% vs 10.6%），差異有統計學意義（P﹤0.05）。AHI 與椎動脈 V1、V2段平均血管內徑（Vd）呈負相關（r＝-0.31，P﹤0.05），與血漿 ET-1水平無顯著相關（P＞0.05）。夜間最低動脈血氧（LSaO2）與 Vd 呈正相關，（r＝0.36），與 ET-1呈負相關（r＝-0.41），均 P﹤0.05。結論：OSAHS 患者椎動脈狹窄、粥樣硬化斑塊髮生率增高；反複呼吸暫停、夜間缺氧引起血漿 ET-1升高可導緻椎動脈損傷。
목적：탐토조새성수면호흡잠정종합정（OSAHS）여추동맥협착、혈장내피소-1（ET-1）지간적관계。방법：선택경다도수면감측의검측，수면호흡잠정저통기지수（AHI）≥5차/ h 적104례 OSAHS 환자여 AHI﹤5차/ h 적47례정상대조조환자작위연구대상，채초검측환자추동맥병변，매련면역반응측정혈장 ET-1수평。결과：OSAHS 조환자추동맥협착발생솔、반괴형성솔명현고우대조조，분별위（29.8% vs 12.8%）、（26.9% vs 10.6%），차이유통계학의의（P﹤0.05）。AHI 여추동맥 V1、V2단평균혈관내경（Vd）정부상관（r＝-0.31，P﹤0.05），여혈장 ET-1수평무현저상관（P＞0.05）。야간최저동맥혈양（LSaO2）여 Vd 정정상관，（r＝0.36），여 ET-1정부상관（r＝-0.41），균 P﹤0.05。결론：OSAHS 환자추동맥협착、죽양경화반괴발생솔증고；반복호흡잠정、야간결양인기혈장 ET-1승고가도치추동맥손상。
Objective:To investigate the correlation of obstructive sleep apnea-hypopnea syndrome (OSAHS ) with vertebral artery stenosis and plasma endothelin-1 ( ET-1 ). Methods:Determined by polysomnographic monitor,104 OSAHS patients whose apnea-hypopnea index( AHI)≥ 5 times/ h( OSAHS group)and 47 patients whose AHI﹤5times/ h(normal control group)were included as the subjects in the study. Color Doppler ultrasound was used to examine vertebral artery lesions. Plasma ET-1 level was measured by enzyme-linked immunosorbent assay(ELISA). Results:The incidence of vertebral artery stenosis and plaque formation in OSAHS group were significantly higher than those in the control group(29.8% vs. 12.8%,26.9% vs. 10.6%),with statistically significant differences( P﹤ 0.05). AHI was negatively correlated with mean vessel diameter in V1 and V2 segments(r = -0.31,P﹤0.05). No significant correlation was found between AHI and plasma ET-1 level. The night-time lowest arterial oxygen saturation(LSaO2 )was positively correlated with Vd and negatively correlated with ET-1(r = 0.36,r = -0.41,all P﹤0.05). Conclusion:The occurrence of vertebral artery stenosis and atherosclerotic plaque increase in OSAHS patients. Increased plasma ET-1 induced by recurrent apnea and night-time hypoxemia may lead to vertebral artery lesions.
