中华糖尿病杂志
中華糖尿病雜誌
중화당뇨병잡지
CHINES JOURNAL OF DLABETES MELLITUS
2015年
7期
442-446
,共5页
董雪洁%潘清蓉%徐援%王广
董雪潔%潘清蓉%徐援%王廣
동설길%반청용%서원%왕엄
载脂蛋白B%非高密度脂蛋白胆固醇%糖尿病,2型
載脂蛋白B%非高密度脂蛋白膽固醇%糖尿病,2型
재지단백B%비고밀도지단백담고순%당뇨병,2형
Apolipoprotein-B%Non-high density lipoprotein cholesterol%Diabetes mellitus,type 2
目的：分析在2型糖尿病（T2DM）患者血脂风险评估中非高密度脂蛋白胆固醇（non?HDLC）和载脂蛋白B (Apo B)的一致性。方法选取2013年1月至2014年1月于首都医科大学附属北京朝阳医院内分泌科就诊的460例无心脑血管疾病病史的初诊T2DM患者为研究对象，记录身高、体重，计算体质指数（BMI）,测定血脂等相关指标，分析Apo B和non?HDLC的相关性；依据美国糖尿病协会/美国心脏病学会(ADA/ACC)、美国血脂协会(NLA)针对糖尿病患者提出的血脂目标值，采用Kappa分析和线性回归分析T2DM患者低密度脂蛋白胆固醇(LDL?C)、non?HDLC、Apo B达标的一致性情况。结果对所有入选的糖尿病患者Apo B和non?HDLC水平进行相关性分析显示，二者间具有相关性( r=0.68，P<0.001)。对114例糖尿病合并高甘油三酯(TG)血症(>200 mg/dl)患者分析显示，Apo B和non?HDLC呈显著正相关(r=0.86，P<0.001)。此外，在Apo B<90 mg/dl的T2DM患者中，40%不能同时满足non?HDLC<130 mg/dl的目标值；16.9%患者ApoB<80 mg/dl，而non?HDLC≥100 mg/dl；12%患者non?HDLC<100 mg/dl，而Apo B≥80 mg/dl；4.4%的患者Apo B<70 mg/dl，而non?HDLC>100 mg/dl；24%的患者non?HDLC<100 mg/dl，而Apo B≥70 mg/dl。结论在临床实际中，糖尿病患者的non?HDLC和Apo B水平具有较好的相关性，一定程度上可替代Apo B作为评价糖尿病患者血脂异常导致心血管风险的参考指标。
目的：分析在2型糖尿病（T2DM）患者血脂風險評估中非高密度脂蛋白膽固醇（non?HDLC）和載脂蛋白B (Apo B)的一緻性。方法選取2013年1月至2014年1月于首都醫科大學附屬北京朝暘醫院內分泌科就診的460例無心腦血管疾病病史的初診T2DM患者為研究對象，記錄身高、體重，計算體質指數（BMI）,測定血脂等相關指標，分析Apo B和non?HDLC的相關性；依據美國糖尿病協會/美國心髒病學會(ADA/ACC)、美國血脂協會(NLA)針對糖尿病患者提齣的血脂目標值，採用Kappa分析和線性迴歸分析T2DM患者低密度脂蛋白膽固醇(LDL?C)、non?HDLC、Apo B達標的一緻性情況。結果對所有入選的糖尿病患者Apo B和non?HDLC水平進行相關性分析顯示，二者間具有相關性( r=0.68，P<0.001)。對114例糖尿病閤併高甘油三酯(TG)血癥(>200 mg/dl)患者分析顯示，Apo B和non?HDLC呈顯著正相關(r=0.86，P<0.001)。此外，在Apo B<90 mg/dl的T2DM患者中，40%不能同時滿足non?HDLC<130 mg/dl的目標值；16.9%患者ApoB<80 mg/dl，而non?HDLC≥100 mg/dl；12%患者non?HDLC<100 mg/dl，而Apo B≥80 mg/dl；4.4%的患者Apo B<70 mg/dl，而non?HDLC>100 mg/dl；24%的患者non?HDLC<100 mg/dl，而Apo B≥70 mg/dl。結論在臨床實際中，糖尿病患者的non?HDLC和Apo B水平具有較好的相關性，一定程度上可替代Apo B作為評價糖尿病患者血脂異常導緻心血管風險的參攷指標。
목적：분석재2형당뇨병（T2DM）환자혈지풍험평고중비고밀도지단백담고순（non?HDLC）화재지단백B (Apo B)적일치성。방법선취2013년1월지2014년1월우수도의과대학부속북경조양의원내분비과취진적460례무심뇌혈관질병병사적초진T2DM환자위연구대상，기록신고、체중，계산체질지수（BMI）,측정혈지등상관지표，분석Apo B화non?HDLC적상관성；의거미국당뇨병협회/미국심장병학회(ADA/ACC)、미국혈지협회(NLA)침대당뇨병환자제출적혈지목표치，채용Kappa분석화선성회귀분석T2DM환자저밀도지단백담고순(LDL?C)、non?HDLC、Apo B체표적일치성정황。결과대소유입선적당뇨병환자Apo B화non?HDLC수평진행상관성분석현시，이자간구유상관성( r=0.68，P<0.001)。대114례당뇨병합병고감유삼지(TG)혈증(>200 mg/dl)환자분석현시，Apo B화non?HDLC정현저정상관(r=0.86，P<0.001)。차외，재Apo B<90 mg/dl적T2DM환자중，40%불능동시만족non?HDLC<130 mg/dl적목표치；16.9%환자ApoB<80 mg/dl，이non?HDLC≥100 mg/dl；12%환자non?HDLC<100 mg/dl，이Apo B≥80 mg/dl；4.4%적환자Apo B<70 mg/dl，이non?HDLC>100 mg/dl；24%적환자non?HDLC<100 mg/dl，이Apo B≥70 mg/dl。결론재림상실제중，당뇨병환자적non?HDLC화Apo B수평구유교호적상관성，일정정도상가체대Apo B작위평개당뇨병환자혈지이상도치심혈관풍험적삼고지표。
Objective To assess the concordance rate of lipid risk between non-high density lipoprotein cholesterol (non?HDLC) and apolipoproteinB (ApoB) targets in patients with diabetes. Methods A total of 460 patients from Beijing Chaoyang hospital with newly diagnosed type 2 diabetes without history of cardio?cerebral vascular disease were enrolled in this study during the period from Jan 2013 to Jan 2014. Body height, body weight, body mass index (BMI) and blood lipid were measured.Data from 460 determinations of low density lipoprotein cholesterol(LDL-C), non-HDLC and Apo B in patients were analyzed. To evaluate the relation between Non-HDLC and Apo B in patients with diabetes with triglyceride (TG) 200?499 mg/dl. Rates of discordance were calculated, based on the currently recommended LDL-C, non-HDLC, and Apo-B goals acknowledged by the American Diabetes Association (ADA) and American Collegeof Cardiology (ACC) panel. Data was analyzed by linear regression and Kappa analysis to show the concordance of LDL-C, non-HDLC and Apo B in T2DM patients. Results In patients with diabetes and hypertriglyceridemia, a positive relationship exists between non-HDLC and Apo?B observed by correlated analysis(r=0.86,P<0.001), whereas a weak correlation among the overall diabetes. In patients with non?HDLC goal of<130 mg/dl, there was a discordance with Apo?B level goal of<90 mg/dl in 40%of samples. In patients with non?HDLC goal of<100 mg/dl, 12%of samples had Apo B>80 and 16.9%had Apo B<80 mg/dl. Using the Apo B goal of<70 mg/dl, these numbers were 24% and 4.4% respectively. Conclusions In practice, non?HDLC and ApoB have an obvious correlation in diabetes patients. To some extent, these two parameters have the equivalence in assessment of cardiovascular risks in diabetes with dyslipidemia.
