CAJ | 학술논문

细菌耐药性问题已逐渐成为社会广泛关注的问题。然而，可运用于临床的新型抗生素却十分匮乏。这主要是因为细菌的耐药机制极其复杂，我们对细菌耐药机制的理解不够全面和深入。近几年，多种生物小分子被发现能够使细菌获得广谱的耐药性，并被证明是广泛存在于细菌中的一种耐药机制，这是对目前细菌耐药理论和模型的一个非常重要的补充，更有助于在抗生素的研发过程中寻找新的作用靶标。我们通过总结分析一氧化氮、硫化氢及吲哚这3种信号小分子与细菌耐药的相关研究进展，探讨信号小分子使细菌获得耐药性的相关机制。
세균내약성문제이축점성위사회엄범관주적문제。연이，가운용우림상적신형항생소각십분궤핍。저주요시인위세균적내약궤제겁기복잡，아문대세균내약궤제적리해불구전면화심입。근궤년，다충생물소분자피발현능구사세균획득엄보적내약성，병피증명시엄범존재우세균중적일충내약궤제，저시대목전세균내약이론화모형적일개비상중요적보충，경유조우재항생소적연발과정중심조신적작용파표。아문통과총결분석일양화담、류화경급신타저3충신호소분자여세균내약적상관연구진전，탐토신호소분자사세균획득내약성적상관궤제。
The problem of bacterial resistance has become the social widespread concern. However, the new anti?biotics in the clinical application are very scarce. Our understanding of the mechanisms of bacterial resistance is not comprehensive and in-depth enough mainly because they are very complicated. But in recent years, a variety of small signaling molecule are found to make bacteria drug resistance against broad spectrum antibiotics which is shown to be widely existed in bacteria as a mechanism of resistance. It is a very important supplement to bacteri?al resistance theory and model at present, and more conducive to choose appropriate targets in the development process of new antibiotics. In this review, we summarized and analyzed the correlation and mechanism of bacterial resistance and small signaling molecule including nitric oxide, hydrogen sulfide and indole.