CAJ | 학술논문

目的：探讨血红素加氧酶-1基因多态性与急性心肌梗死发病风险之间的关系。方法选取连续的80例急性ST段抬高性心肌梗死患者和85例健康体检者（对照组），采用聚合酶链反应和凝胶电泳方法分析HO-1基因启动子区域c的分布是否存在差异。结果 HO-1基因启动子区域（GT）n重复序列存在差异；急性心肌梗死组和对照组L/L基因型（P=0.003）及L型等位基因（P=0.001）频率分布差异具有统计学意义；多因素回归分析显示HO-1基因多态性、吸烟史、高血压、糖尿病及总胆固醇水平是急性心肌梗死的预测因子。结论血红素加氧酶-1基因启动子区域遗传多态性与急性心肌梗死的发病、以及疾病进展密切相关。
목적：탐토혈홍소가양매-1기인다태성여급성심기경사발병풍험지간적관계。방법선취련속적80례급성ST단태고성심기경사환자화85례건강체검자（대조조），채용취합매련반응화응효전영방법분석HO-1기인계동자구역c적분포시부존재차이。결과 HO-1기인계동자구역（GT）n중복서렬존재차이；급성심기경사조화대조조L/L기인형（P=0.003）급L형등위기인（P=0.001）빈솔분포차이구유통계학의의；다인소회귀분석현시HO-1기인다태성、흡연사、고혈압、당뇨병급총담고순수평시급성심기경사적예측인자。결론혈홍소가양매-1기인계동자구역유전다태성여급성심기경사적발병、이급질병진전밀절상관。
Objective The aim of this study was to investigate the relationship between heme oxygenase-1 gene polymorphism and acute myocardial infarction. MethodsAfter exclusion, 80 patients with AMI and 85 cases of healthy check-up were prospectively enroled in this study. Polymerase chain reaction and the modified polyacrylamide gel electrophoresis methods were used to analyze HO-1 gene promoter regions (GT)n distribution.Results There were obvious difference between two groups in HO-1 gene promoter regions (GT)n repetitive sequence.Acute myocardial infarction group and the control group L/L genotype (P=0.003) and L alele frequency (P=0.001) differences were statisticaly significant. Multiple factors regression analysis showed that HO-1 gene polymorphism, smoking history, hypertension, diabetes, and total cholesterol levels were predictors of acute myocardial infarction.Conclusion HO-1 gene promoter regions (GT)n repetitive sequence’s genetic polymorphism is associated with the occurrence and development of acute myocardial infarction.