CAJ | 학술논문

肝癌肿瘤微环境中巨噬细胞（TAMs）能减弱机体对肿瘤的免疫反应，促进恶性肿瘤的组织重建、血管生成。在动物实验中，特定类型巨噬细胞能促使肿瘤转移，而相关临床研究发现，TAMs和肿瘤的不良预后密切相关。TAMs具有多种表型状态，主要来源于血液循环中的单核细胞，肿瘤微环境影响巨噬细胞后，使其处于非正常激活状态，即M2型TAMs，其特点是可塑性高、分化不完全。基于巨噬细胞的促肿瘤作用，目前针对巨噬细胞的募集、活化、促血管生成活性、基质重塑、存活等方面制定的靶向药物治疗进入了临床试验。
간암종류미배경중거서세포（TAMs）능감약궤체대종류적면역반응，촉진악성종류적조직중건、혈관생성。재동물실험중，특정류형거서세포능촉사종류전이，이상관림상연구발현，TAMs화종류적불량예후밀절상관。TAMs구유다충표형상태，주요래원우혈액순배중적단핵세포，종류미배경영향거서세포후，사기처우비정상격활상태，즉M2형TAMs，기특점시가소성고、분화불완전。기우거서세포적촉종류작용，목전침대거서세포적모집、활화、촉혈관생성활성、기질중소、존활등방면제정적파향약물치료진입료림상시험。
Macrophages in liver tumor microenvironment (TAMs) can weaken the body's immune response to tumor, promote the malignant tumor tissue reconstruction, and angiogenesis. In animal experiments, specific type macrophages can cause tumor metastasis, and the related clinical stud-ies found that TAMs and closely related to the poor prognosis of the tumor. TAMs had many phenotypic state, mainly comes from the circulation of the blood mononuclear cells,tumor microen-vironment influence after the macrophages, make its tracker is activated, the M2 TAMs, charac-terized by high plasticity, incomplete differentiation. Based on the effect on promoting tumor macrophages, at present, in view of the macrophages collect, activation, promote angiogenesis ac-tivity, matrix remodeling and survival of targeted drug therapy had entered clinical trials.