CAJ | 학술논문

目的：探讨高空环境歼击飞行员的骨代谢生化指标变化及意义。方法：检测空军某部129名歼击飞行员（均为男性，身体健康，年龄26~48岁，平均飞行时间1500 h±100 h）的4项骨代谢生化指标：骨形成标志物N端骨钙素（N-MID）和总Ⅰ型胶原氨基端前肽（PINP）、骨吸收标志物β胶原降解产物（β-crosslaps）、调节钙平衡的甲状旁腺素（PTH）。根据机型分为二代机组与三代机组，结果采用t检验进行组间比较；按照年龄分为20~29岁、30~39岁、40~49岁年龄组，结果采用单因素方差分析进行组间比较。结果：2代歼击飞行员骨代谢生化指标比较差异无统计学意义。20~29岁年龄组中骨形成标志物N-MID和PINP浓度比其他年龄组明显升高，差异有统计学意义（P<0.01）；20~29岁年龄组中骨吸收标志物β-crosslaps浓度比40~49岁年龄组显著升高，差异有统计学意义（P<0.01）；骨吸收标志物PTH在各年龄组间的差异无统计学意义（P>0.05）。结论：歼击飞行员骨形成标志物、骨吸收标志物在20~29岁达到最高水平，提示在人体峰值骨量时骨转换处于较高水平，40~60岁骨代谢生化指标浓度最低，骨吸收和骨形成处于动态平衡，骨转换水平较低。密切监测骨代谢生化指标变化，对维护飞行员骨健康，确保飞行安全有积极意义。
목적：탐토고공배경섬격비행원적골대사생화지표변화급의의。방법：검측공군모부129명섬격비행원（균위남성，신체건강，년령26~48세，평균비행시간1500 h±100 h）적4항골대사생화지표：골형성표지물N단골개소（N-MID）화총Ⅰ형효원안기단전태（PINP）、골흡수표지물β효원강해산물（β-crosslaps）、조절개평형적갑상방선소（PTH）。근거궤형분위이대궤조여삼대궤조，결과채용t검험진행조간비교；안조년령분위20~29세、30~39세、40~49세년령조，결과채용단인소방차분석진행조간비교。결과：2대섬격비행원골대사생화지표비교차이무통계학의의。20~29세년령조중골형성표지물N-MID화PINP농도비기타년령조명현승고，차이유통계학의의（P<0.01）；20~29세년령조중골흡수표지물β-crosslaps농도비40~49세년령조현저승고，차이유통계학의의（P<0.01）；골흡수표지물PTH재각년령조간적차이무통계학의의（P>0.05）。결론：섬격비행원골형성표지물、골흡수표지물재20~29세체도최고수평，제시재인체봉치골량시골전환처우교고수평，40~60세골대사생화지표농도최저，골흡수화골형성처우동태평형，골전환수평교저。밀절감측골대사생화지표변화，대유호비행원골건강，학보비행안전유적겁의의。
Objective: To investigate the changes of biochemical markers of bone metabolism and the possible sig?nificance in fighter pilots in high-altitude condition. Methods: To evaluate four biochemical markers of bone in 129 fighter pilots(male, healthy, and aged 26~48 years, with an average flight time of 1500 h±100 h): bone forma?tion marker N-terminal osteocalcin(N-MID), total collagen typeⅠamino-terminal propeptide(PINP), bone resorp?tion markers(β-crosslaps), and parathyroid hormone(PTH). The pilots were divided into two groups according to aircraft type, namely second-generation unit and three generations unit, and t test was used to compare the differ?ences between groups. The pilots were divided into three groups according to age, namely 20~29 year-old age group, 30~39 year-old age group, and 40~49 age group, and ANOVA was used to compare the differences among biochemical markers. Results: The bone metabolic markers differences in two generations of fighter pilots were not statistically significant. N-MID and PINP concentrations in 20~29 age group were significantly higher than those in other age groups(P<0.01). In comparison to that in 40~49 age group, bone resorption markers β-crosslaps con?centration significantly increased in 20~29 age group(P<0.01). There were no significantly changes in PTH concen?tration(P>0.05). Conclusion: The markers of bone formation, and bone resorption reached the peak in the 20~29 year-old pilots, suggesting that a high level of bone turnover happens in the period of peak bone mass. The bone metabolic markers were at the lowest concentration in 40~60 years-old pilots, indicating that bone resorption and bone formation are in a dynamic equilibrium, and the level of bone turnover is low. Close monitoring the changes in bone metabolism has a positive significance for maintaining bone health and ensuring flight safety of pilots.