中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
2015年
5期
276-280
,共5页
黄希田%刘雪峰%阮巧玲%邵凌云%刘伟%蔡丽敏%凌乔%沈瑶杰%杨清銮%孙峰%林宇航%高岩%张文宏
黃希田%劉雪峰%阮巧玲%邵凌雲%劉偉%蔡麗敏%凌喬%瀋瑤傑%楊清鑾%孫峰%林宇航%高巖%張文宏
황희전%류설봉%원교령%소릉운%류위%채려민%릉교%침요걸%양청란%손봉%림우항%고암%장문굉
结核%硅沉着病%矽尘%危险因素
結覈%硅沉著病%矽塵%危險因素
결핵%규침착병%석진%위험인소
Tuberculosis%Silicosis%Silica dust%Risk factors
目的:了解矽尘暴露者包括硅沉着病患者的结核病患病情况,并分析该人群中结核病发病的危险因素。方法对浙江温岭地区1227例矽尘暴露者进行现场调查,采集基本信息,行胸部 X 线片检查,收集痰标本行结核分枝杆菌培养及鉴定。在单因素分析中,连续变量比较采用两样本 t 检验;分类变量组间两两比较采用χ2检验。多因素分析采用二元 Logistic 回归计算优势比(OR)及95%可信区间(CI )。结果共获得1204例矽尘暴露者完整的基本信息,其中男1201例(99.8%),平均年龄(59.4±6.8)岁。其中硅沉着病0+期(疑似患者)、Ⅰ、Ⅱ、Ⅲ期的患者分别为172例(14.3%)、255例(21.2%)、160例(13.3%)和617例(51.2%)。该人群中结核病患病率约为7300/10万,发病危险因素有硅沉着病Ⅱ期(OR=2.96,95%CI :1.05~8.32,P =0.04)、硅沉着病Ⅲ期(OR =3.88,95%CI :1.58~9.56,P <0.01)、接触结核病患者(OR=4.14,95%CI :1.91~8.98,P <0.01)。硅沉着病合并肺结核患者缺乏特异性症状,发热、体质量减轻较非肺结核患者多见。结论矽尘暴露者包括硅沉着病患者是结核病的高发人群,尤其是硅沉着病Ⅱ期及Ⅲ期、有结核病患者接触史的患者。
目的:瞭解矽塵暴露者包括硅沉著病患者的結覈病患病情況,併分析該人群中結覈病髮病的危險因素。方法對浙江溫嶺地區1227例矽塵暴露者進行現場調查,採集基本信息,行胸部 X 線片檢查,收集痰標本行結覈分枝桿菌培養及鑒定。在單因素分析中,連續變量比較採用兩樣本 t 檢驗;分類變量組間兩兩比較採用χ2檢驗。多因素分析採用二元 Logistic 迴歸計算優勢比(OR)及95%可信區間(CI )。結果共穫得1204例矽塵暴露者完整的基本信息,其中男1201例(99.8%),平均年齡(59.4±6.8)歲。其中硅沉著病0+期(疑似患者)、Ⅰ、Ⅱ、Ⅲ期的患者分彆為172例(14.3%)、255例(21.2%)、160例(13.3%)和617例(51.2%)。該人群中結覈病患病率約為7300/10萬,髮病危險因素有硅沉著病Ⅱ期(OR=2.96,95%CI :1.05~8.32,P =0.04)、硅沉著病Ⅲ期(OR =3.88,95%CI :1.58~9.56,P <0.01)、接觸結覈病患者(OR=4.14,95%CI :1.91~8.98,P <0.01)。硅沉著病閤併肺結覈患者缺乏特異性癥狀,髮熱、體質量減輕較非肺結覈患者多見。結論矽塵暴露者包括硅沉著病患者是結覈病的高髮人群,尤其是硅沉著病Ⅱ期及Ⅲ期、有結覈病患者接觸史的患者。
목적:료해석진폭로자포괄규침착병환자적결핵병환병정황,병분석해인군중결핵병발병적위험인소。방법대절강온령지구1227례석진폭로자진행현장조사,채집기본신식,행흉부 X 선편검사,수집담표본행결핵분지간균배양급감정。재단인소분석중,련속변량비교채용량양본 t 검험;분류변량조간량량비교채용χ2검험。다인소분석채용이원 Logistic 회귀계산우세비(OR)급95%가신구간(CI )。결과공획득1204례석진폭로자완정적기본신식,기중남1201례(99.8%),평균년령(59.4±6.8)세。기중규침착병0+기(의사환자)、Ⅰ、Ⅱ、Ⅲ기적환자분별위172례(14.3%)、255례(21.2%)、160례(13.3%)화617례(51.2%)。해인군중결핵병환병솔약위7300/10만,발병위험인소유규침착병Ⅱ기(OR=2.96,95%CI :1.05~8.32,P =0.04)、규침착병Ⅲ기(OR =3.88,95%CI :1.58~9.56,P <0.01)、접촉결핵병환자(OR=4.14,95%CI :1.91~8.98,P <0.01)。규침착병합병폐결핵환자결핍특이성증상,발열、체질량감경교비폐결핵환자다견。결론석진폭로자포괄규침착병환자시결핵병적고발인군,우기시규침착병Ⅱ기급Ⅲ기、유결핵병환자접촉사적환자。
Objective To investigate the prevalence of tuberculosis among silicosis patients and silica exposure patients,and to analysis the risk factors of tuberculosis among these population.Methods A total of 1 227 silica exposure patients from Wenling,Zhejiang were enrolled in this field study.Basic demographic information was collected and chest X-ray was taken for each patient.Sputum was collected for Mycobacterium tuberculosis culture and strain identification. In univariate analysis,t test was performed for continuous variables andχ2 test for categorical variables.In multivariate analysis,the odds ratio (OR )was calculated along with a 95 % confidence interval (CI )by binary Logistic regression. Results A total of 1 204 silica exposure patients had full basic information and 99.8% were male patients with mean age of (59.4 ± 6.8 )years.The patients in phase 0 + to phase Ⅲ were 172 (14.3%),255 (21 .2%),160 (13.3%)and 617 (51 .2%),respectively.The tuberculosis prevalence rate was about 7.3% among these population.The risk factors for tuberculosis including phase Ⅱ silicosis (OR =2.96, 95 %CI :1 .05 -8.32,P =0.04)and phase Ⅲ silicosis (OR=3.88,95 %CI :1 .58-9.56,P <0.01),and contacting with tuberculosis patients (OR=4.14,95 %CI :1 .91 -8.98,P <0.01).Patients complicated with tuberculosis lacked specific symptoms,but fever and weight loss were more frequent.Conclusion Tuberculosis is highly prevalent in silicotic patients,especially in patients with phase Ⅱ/Ⅲ silicosis and in patients with tuberculosis contact history.