CAJ | 학술논문

目的：研究阿尔茨海默病（AD）患者脑电时间序列的同步性。方法采集AD患者和正常对照者各8名的16导联脑电图（EEG）数据，分别对2组EEG的全频段、δ（0.5~4 Hz）、θ（4~8 Hz）、α（8~13 Hz）和β频段（13~30 Hz）信号进行同步似然分析，比较不同频段的平均同步似然系数值并进行统计学分析。结果 AD组全频段、θ频段和α频段的平均同步似然系数值均小于对照组，差异有统计学意义（P<0.05）；2组δ和β频段的平均同步似然系数值差异无统计学意义（P>0.05）。结论 AD组全频段、θ频段和α频段的EEG同步性降低，提示在θ和α频段内AD患者不同脑区的协同信息处理能力下降，为进一步研究AD患者大脑功能连接特性提供支持。
목적：연구아이자해묵병（AD）환자뇌전시간서렬적동보성。방법채집AD환자화정상대조자각8명적16도련뇌전도（EEG）수거，분별대2조EEG적전빈단、δ（0.5~4 Hz）、θ（4~8 Hz）、α（8~13 Hz）화β빈단（13~30 Hz）신호진행동보사연분석，비교불동빈단적평균동보사연계수치병진행통계학분석。결과 AD조전빈단、θ빈단화α빈단적평균동보사연계수치균소우대조조，차이유통계학의의（P<0.05）；2조δ화β빈단적평균동보사연계수치차이무통계학의의（P>0.05）。결론 AD조전빈단、θ빈단화α빈단적EEG동보성강저，제시재θ화α빈단내AD환자불동뇌구적협동신식처리능력하강，위진일보연구AD환자대뇌공능련접특성제공지지。
Objective To study the synchronization of electroencephalogram (EEG) in the patients with Alzheimer's disease (AD). Methods Sixteen-channel EEG was recorded under resting, eyes-closed condition in 8 AD patients and 8 control subjects. After data preprocessing, the synchronization likelihood was measured between pairs of EEG channels for the full band,δband (0.5-4 Hz),θband (4-8 Hz),αband (8-13 Hz) andβband (13-30 Hz) in the AD and control groups. Mean synchronization likelihood values of each frequency band were compared between the two groups. Results At the full band,θband andαband, the mean synchronization likelihood values of the AD group were lower than that of the control group (P<0.05). There was no significant difference in the two groups at theδandβbands (P>0.05). Conclusions The EEG synchronization of AD patients decreases at the full band,θandαbands, suggesting that collaborative information processing ability atθandαbands reduces between different brain regions in the AD patients. The research provides support for further study of the brain functional connectivity characteristics in the AD patients.