CAJ | 학술논문

目的：研究流感泰得预防给药在小鼠体内对H1N1型FM1株流感病毒的抑制作用及对病毒感染小鼠的保护作用。方法：BALB/c小鼠随机分为正常对照组，病毒对照组，磷酸奥司他韦组，流感泰得2.5、5、10 mg/kg组，提前24 h和1 h滴鼻给药2次，于第二次给药1 h后滴鼻感染小鼠造成肺炎模型，连续观察14 d，统计小鼠存活率、平均存活天数、体重变化；按以上方法于造模后第5d天取肺脏，计算肺指数、肺脏病毒滴度。结果：与病毒对照组相比，流感泰得3个剂量组可明显提高病毒感染小鼠的存活率，延长平均存活时间，缓解病毒感染引起的体重降低，降低病毒感染小鼠的肺指数和肺脏病毒滴度。结论：流感泰得在小鼠体内预防给药具有抗H1N1型FM1株流感病毒活性。
목적：연구류감태득예방급약재소서체내대H1N1형FM1주류감병독적억제작용급대병독감염소서적보호작용。방법：BALB/c소서수궤분위정상대조조，병독대조조，린산오사타위조，류감태득2.5、5、10 mg/kg조，제전24 h화1 h적비급약2차，우제이차급약1 h후적비감염소서조성폐염모형，련속관찰14 d，통계소서존활솔、평균존활천수、체중변화；안이상방법우조모후제5d천취폐장，계산폐지수、폐장병독적도。결과：여병독대조조상비，류감태득3개제량조가명현제고병독감염소서적존활솔，연장평균존활시간，완해병독감염인기적체중강저，강저병독감염소서적폐지수화폐장병독적도。결론：류감태득재소서체내예방급약구유항H1N1형FM1주류감병독활성。
Objective: To study the antiviral activity of Flutide against influenza virus A/FM/1/47(H1N1) in vi?vo. Methods: The BALB/c mice were randomly divided into normal control, influenza virus, Oseltamivir and Flutide (2.5, 5, 10 mg/kg). The mice were given Oseltamivir and Flutide twice starting 24 and 1 h before virus chal?lenge. The survival rate, mean survival time, changes of body weight, lung index and viral titers in the lung were calculated. Results: Flutide significantly increased the survival rate, prolonged the mean survival time and reduced the viral titers in the lung and the lung index, compared with that of untreated virus control. Conclusion: The re?sults obtained suggest that Flutide has protective effect against infection by FM1 of H1N1 in vivo.