CAJ | 학술논문

目的：探讨发热伴血小板减少综合征（SFTS）患者骨髓形态学特点及其临床应用价值。方法回顾性分析2011年7月至2014年11月台州医院新布尼亚病毒核酸阳性的6例 SFTS 患者的骨髓形态学和临床资料。结果6例 SFTS 患者骨髓涂片中淋巴样和单核样组织细胞均有不同程度的增多，比例为0．02～0．23，且均伴有噬血现象。其中2例符合噬血细胞性淋巴组织细胞增生症（HLH）的临床诊断标准，4例为 HLH 高度疑似患者。结论 SFTS 疾病进展很可能与新布尼亚病毒继发的HLH 密切相关，骨髓细胞形态学检查有助于 SFTS 的早期鉴别诊断。
목적：탐토발열반혈소판감소종합정（SFTS）환자골수형태학특점급기림상응용개치。방법회고성분석2011년7월지2014년11월태주의원신포니아병독핵산양성적6례 SFTS 환자적골수형태학화림상자료。결과6례 SFTS 환자골수도편중림파양화단핵양조직세포균유불동정도적증다，비례위0．02～0．23，차균반유서혈현상。기중2례부합서혈세포성림파조직세포증생증（HLH）적림상진단표준，4례위 HLH 고도의사환자。결론 SFTS 질병진전흔가능여신포니아병독계발적HLH 밀절상관，골수세포형태학검사유조우 SFTS 적조기감별진단。
Objective To investigate the bone marrow morphology characteristics in patients with severe fever with thrombocytopenia syndrome (SFTS)and to evaluate the clinical value of bone marrow morphology examination in the diagnosis of SFTS.Methods The bone marrow morphology and clinical data of six newly diagnosed SFTS patients with positive test of novel bunyavirus infection admitted to Taizhou Hospital from July 2011 to November 2014 were retrospectively analyzed.Results The increased ratio of lymphoid and monocytoid histiocytes (0.02 - 0.23 )and hemophagocytic phenomenon were observed in all of the six patients′ bone marrow smears.Two of the six cases were diagnosed with hemophagocytic lymphohistiocytosis (HLH)according to the clinical diagnosis criteria and the remaining four cases were defined as highly suspected HLH.Conclusions The progression of SFTS disease might be closely related with HLH induced by novel bunyavirus infection.Morphology examination of bone marrow smear is beneficial for the early differential diagnosis of SFTS.