CAJ | 학술논문

目的：研究丙泊酚麻醉对老年大鼠认知功能的影响。方法选取96只雄性SD老年大鼠（16月龄）为研究对象，在丙泊酚麻醉后第7、30、90天，应用恐惧记忆实验测试老年大鼠长期记忆功能（每个时间节点各12点，共36只）；在麻醉后5 d内应用自主空间探索实验测试老年大鼠工作记忆功能（每个时间节点各12点，共60只）。结果在麻醉后7、30、90 d，丙泊酚组与对照组老年大鼠长期记忆功能的差异均无统计学意义（P>0.05）。麻醉后2 d内，丙泊酚组老年大鼠工作记忆功能受损（P<0.05）；在第3、4、5天，2组老年大鼠空间工作记忆差异均无统计学意义（P>0.05）。结论实验结果表明临床剂量丙泊酚麻醉会导致老年大鼠48 h内的工作记忆功能损伤，但不会损伤其长期记忆功能。
목적：연구병박분마취대노년대서인지공능적영향。방법선취96지웅성SD노년대서（16월령）위연구대상，재병박분마취후제7、30、90천，응용공구기억실험측시노년대서장기기억공능（매개시간절점각12점，공36지）；재마취후5 d내응용자주공간탐색실험측시노년대서공작기억공능（매개시간절점각12점，공60지）。결과재마취후7、30、90 d，병박분조여대조조노년대서장기기억공능적차이균무통계학의의（P>0.05）。마취후2 d내，병박분조노년대서공작기억공능수손（P<0.05）；재제3、4、5천，2조노년대서공간공작기억차이균무통계학의의（P>0.05）。결론실험결과표명림상제량병박분마취회도치노년대서48 h내적공작기억공능손상，단불회손상기장기기억공능。
Objective To investigate the effects of propofol anesthesia on cognitive function of aged rats. Methods Ninety-six male aged SD rats (16 months) were collected and given propofol anesthesia via tail vein catheter. At 7, 30, and 90 d after anesthesia, fear conditioning experiment was performed to test long-term memory of the aged rats (12 rats at each time point, total 36 rats). At 1, 2, 3, 4, and 5 d after anesthesia, spontaneous alternation in Y-maze experiment was performed to test spatial working memory of the aged rats (12 rats at each time point, total 60 rats). Results There were no statistical differences in long-term memory at 7, 30, and 90 d after anesthesia between the propofol group and control group (P>0.05). While spatial working memory of aged rats in propofol group was impaired at 1 and 2 d after anesthesia (P<0.05), working memory of aged rats in propofol group was normal at 3, 4, and 5 d after anesthesia and there were no statistical differences between the experiment and control group (P>0.05). Conclusions These results indicate that clinical dose propofol anesthesia will not induce long-term memory impairment of aged rats, although it impairs spatial working memory of aged rats within 48 h after anesthesia.