CAJ | 학술논문

外泌体是来源于细胞的脂质微囊泡，内含多种蛋白质、脂质、核酸，可通过外泌体运输到靶细胞，影响靶细胞生物学活性。研究表明，外泌体介导细胞间信号传递在心肌损伤、血管再生、心脏重塑以及动脉粥样斑块形成等过程中发挥重要作用，因而具有潜在的临床应用价值，可能成为心血管疾病早期诊断、疗效监测、预后判断的循环标志物，以及更为有效的CVD靶向治疗药物载体。（中华检验医学杂志，2015，38：439－441）
외비체시래원우세포적지질미낭포，내함다충단백질、지질、핵산，가통과외비체운수도파세포，영향파세포생물학활성。연구표명，외비체개도세포간신호전체재심기손상、혈관재생、심장중소이급동맥죽양반괴형성등과정중발휘중요작용，인이구유잠재적림상응용개치，가능성위심혈관질병조기진단、료효감측、예후판단적순배표지물，이급경위유효적CVD파향치료약물재체。（중화검험의학잡지，2015，38：439－441）
Exosomes are nanosized lipid vesicles released from cells .They are believed to contain proteins, lipids and nucleic acid cargos , and are capable of deliver their cargos to recipient cells , which in turn alter the expression of genes in neighboring cells .An increasing body of evidence indicates that they play a pivotal role in cell-to-cell communication , which is hijacked during various physiological and pathological conditions , such as myocardial damage , angiogenesis , cardiac remodeling and atherogenesis plaque formation .Further research of intercellular communication mediated by exosomes may potentially aid in the possible application of exosomes for biomarker discovery , curative effects , as well as prognosis of cardiovascular diseases , even the use of exosomes as a therapeutic drug delivery system on the basis of the exosome′s ability to target specific cells , and transfer genetic materials.