中华解剖与临床杂志
中華解剖與臨床雜誌
중화해부여림상잡지
Chinese Journal of Anatomy and Clinics
2015年
4期
339-343
,共5页
王刚%申屠刚%徐云钦%姚有榕%李强
王剛%申屠剛%徐雲欽%姚有榕%李彊
왕강%신도강%서운흠%요유용%리강
周围神经损伤%神经生长因子%缓释系统%神经松解
週圍神經損傷%神經生長因子%緩釋繫統%神經鬆解
주위신경손상%신경생장인자%완석계통%신경송해
Peripheral nerve injuries%Nerve growth factor%Delivery release system%Neurolysis
目的:探讨神经生长因子(NGF)缓释系统在周围神经松解术中的应用疗效。方法对解放军第九八医院全军创伤骨科中心2011年3月—2013年5月收治的36例前臂及腕部正中神经完全断裂患者进行前瞻性研究,在修复术后3个月常规进行神经松解手术,采用单盲随机化法分为A 组(18例)、B 组(18例)。 A 组患者利用自制的缓释系统进行 NGF(共30 mL,质量浓度8.12 mg/mL)局部缓释,B 组患者用等量的 NGF 在神经周围明胶海绵包绕后局部注射。8周后进行神经电生理检查,比较两组患者体感诱发电位(SEP)、复合肌肉动作电位(CMAP)的变化,并对运动神经传导速度(NCV)作进一步分析;24周后分别行英国医学研究委员会(BMRC)感觉及运动功能评定标准评分。结果术后8周 A、B 两组 SEP 中潜伏期分别为(20.56±3.50) ms、(32.25±4.61)ms,波幅分别为(17.22±3.46)μV、(9.90±1.37)μV;A、B 两组 CMAP 中潜伏期分别为(2.10±0.37)ms、(4.31±0.66)ms,波幅分别为(810.9±108.16)μV、(506.61±67.50)μV,两组的 NCV 分别为(41.21±3.34)m/ s、(30.68±2.21)m/ s;与 B 组相比,A 组 SEP、CMAP 潜伏期明显缩短,波幅明显增高,NCV明显增快,差异均有统计学意义(P 值均<0.01),BMRC 感觉功能评分中,A、B 两组的优良率分别为16/18、12/18;运动功能评定中,A、B 两组的优良率分别为14/18、9/18; A 组 BMRC 运动功能优于B 组,差异均有统计学意义(P 值均<0.05)。结论 NGF 缓释系统可明显促进神经松解术后神经功能的恢复,可作为神经损伤后期治疗的补充手段,操作简单,值得临床推广。
目的:探討神經生長因子(NGF)緩釋繫統在週圍神經鬆解術中的應用療效。方法對解放軍第九八醫院全軍創傷骨科中心2011年3月—2013年5月收治的36例前臂及腕部正中神經完全斷裂患者進行前瞻性研究,在脩複術後3箇月常規進行神經鬆解手術,採用單盲隨機化法分為A 組(18例)、B 組(18例)。 A 組患者利用自製的緩釋繫統進行 NGF(共30 mL,質量濃度8.12 mg/mL)跼部緩釋,B 組患者用等量的 NGF 在神經週圍明膠海綿包繞後跼部註射。8週後進行神經電生理檢查,比較兩組患者體感誘髮電位(SEP)、複閤肌肉動作電位(CMAP)的變化,併對運動神經傳導速度(NCV)作進一步分析;24週後分彆行英國醫學研究委員會(BMRC)感覺及運動功能評定標準評分。結果術後8週 A、B 兩組 SEP 中潛伏期分彆為(20.56±3.50) ms、(32.25±4.61)ms,波幅分彆為(17.22±3.46)μV、(9.90±1.37)μV;A、B 兩組 CMAP 中潛伏期分彆為(2.10±0.37)ms、(4.31±0.66)ms,波幅分彆為(810.9±108.16)μV、(506.61±67.50)μV,兩組的 NCV 分彆為(41.21±3.34)m/ s、(30.68±2.21)m/ s;與 B 組相比,A 組 SEP、CMAP 潛伏期明顯縮短,波幅明顯增高,NCV明顯增快,差異均有統計學意義(P 值均<0.01),BMRC 感覺功能評分中,A、B 兩組的優良率分彆為16/18、12/18;運動功能評定中,A、B 兩組的優良率分彆為14/18、9/18; A 組 BMRC 運動功能優于B 組,差異均有統計學意義(P 值均<0.05)。結論 NGF 緩釋繫統可明顯促進神經鬆解術後神經功能的恢複,可作為神經損傷後期治療的補充手段,操作簡單,值得臨床推廣。
목적:탐토신경생장인자(NGF)완석계통재주위신경송해술중적응용료효。방법대해방군제구팔의원전군창상골과중심2011년3월—2013년5월수치적36례전비급완부정중신경완전단렬환자진행전첨성연구,재수복술후3개월상규진행신경송해수술,채용단맹수궤화법분위A 조(18례)、B 조(18례)。 A 조환자이용자제적완석계통진행 NGF(공30 mL,질량농도8.12 mg/mL)국부완석,B 조환자용등량적 NGF 재신경주위명효해면포요후국부주사。8주후진행신경전생리검사,비교량조환자체감유발전위(SEP)、복합기육동작전위(CMAP)적변화,병대운동신경전도속도(NCV)작진일보분석;24주후분별행영국의학연구위원회(BMRC)감각급운동공능평정표준평분。결과술후8주 A、B 량조 SEP 중잠복기분별위(20.56±3.50) ms、(32.25±4.61)ms,파폭분별위(17.22±3.46)μV、(9.90±1.37)μV;A、B 량조 CMAP 중잠복기분별위(2.10±0.37)ms、(4.31±0.66)ms,파폭분별위(810.9±108.16)μV、(506.61±67.50)μV,량조적 NCV 분별위(41.21±3.34)m/ s、(30.68±2.21)m/ s;여 B 조상비,A 조 SEP、CMAP 잠복기명현축단,파폭명현증고,NCV명현증쾌,차이균유통계학의의(P 치균<0.01),BMRC 감각공능평분중,A、B 량조적우량솔분별위16/18、12/18;운동공능평정중,A、B 량조적우량솔분별위14/18、9/18; A 조 BMRC 운동공능우우B 조,차이균유통계학의의(P 치균<0.05)。결론 NGF 완석계통가명현촉진신경송해술후신경공능적회복,가작위신경손상후기치료적보충수단,조작간단,치득림상추엄。
Objective To prepare nerve growth factor delivery release system , and explore its clinical effects on peripheral nerve relaxation. Methods Thirty six patients of patients with median nerve injuries in the forearm and wrist were strictly followed up and accepted neurolysis after 3 months in the 98th Hospital of PLA from March 2011 to May 2013. The patients were randomly divided into group A (18 patients) and B group (18 patients). The NGF(total 30 mL, concentration of 8. 12 mg/ mL) was used to partial release by using the homemade delivery release system in group A, the same amount of NGF was partial injected to Gelatin sponge surrounding peripheral nerve in group B. All patients respectively underwent neural electrophysiological examination after 8 weeks. The somatosensory evoked potentials (SEP) and compound muscle action potentials (CMAP) between different groups were compared, and motor nerve conduction velocity (NCV) was also analyzed. The sensory and motor function evaluation score of British Medical Research Council(BMRC) were performed after 24 weeks. Results The peak latency of the SEP after 8 weeks in A and B groups were (20. 56 ± 3. 50)ms and(32. 25 ± 4. 61)ms, respectively. The volatility were (17. 22 ± 3. 46) μV and (9. 90 ± 1. 37) μV, respectively. The peak latency of the CMAP after 8 weeks in A and B groups were (2. 10 ± 0. 37)ms and(4. 31 ± 0. 66)ms, respectively. The volatility were (810. 9 ± 108. 16)μV and(506. 61 ± 67. 50)μV, the NCV were (41. 21 ± 3. 34)m/ s and(30. 68 ± 2. 21) m/ s, respectively. Compared with the group B, the peak latencies of the SEP and CMAP were shortened significantly and the Volatility was increased significantly in group A, the NCV was faster in group A(all P values < 0. 01). The good rate of the A and B groups in BMRC sensory function score were 16 / 18 and 12 / 18, respectively. The good rate in BMRC motor function score were 14 / 18 and 9 / 18, respectively. The good rate in group A was higher than that in group B( all P values < 0. 05) . Conclusions Nerve growth factor delivery delivery system is effective in promoting the recovery of neurological function after neurolysis , and can be used as a supplementary means of nerve damage in the later stage. It is simple to operate and worthy of promoting.