中国卫生标准管理
中國衛生標準管理
중국위생표준관리
CHINA HEALTH STANDARD MANAGEMENT
2015年
19期
108-110
,共3页
抗胸腺细胞球蛋白%环孢素A%再生障碍性贫血%儿童
抗胸腺細胞毬蛋白%環孢素A%再生障礙性貧血%兒童
항흉선세포구단백%배포소A%재생장애성빈혈%인동
Anti-thymocyte globulin%Cyclosporine A%Aplastic anemia%Children
目的:观察抗胸腺球蛋白(ATG)联合环孢素A(CsA)治疗儿童再生障碍性贫血(AA)的疗效,探讨提高儿童AA疗效的有效方案。方法回顾性分析52例在我院接受正规治疗并且门诊随访时间超过6个月AA患儿的临床资料,其中重型再障(SAA)24例,慢性再障(CAA)28例,所有患儿按治疗方案不同分为2组,对照组为单用CsA治疗,治疗组为ATG联合CsA治疗,比例两组患儿的疗效。结果 CAA组患儿的总有效率为82.1%(23/28),SAA患者总有效率为50.0%(12/24);28例CAA患儿中接受对照组治疗27例,总有效率为81.5%(22/27),接受治疗组治疗1例,总有效率100.0(1/1),两组有效率比较,差异无统计学意义(P >0.05);24例SAA患儿中接受治疗组治疗8例,总有效率25.0%(2/8),接受对照组治疗16例,总有效率75.0%(12/16),治疗组有效率高于对照组,差异具有统计学意义(P <0.05)。结论ATG联合CsA治疗儿童SAA疗效佳,可作为缺乏合适供体进行造血干细胞移植患儿的首选治疗方式。
目的:觀察抗胸腺毬蛋白(ATG)聯閤環孢素A(CsA)治療兒童再生障礙性貧血(AA)的療效,探討提高兒童AA療效的有效方案。方法迴顧性分析52例在我院接受正規治療併且門診隨訪時間超過6箇月AA患兒的臨床資料,其中重型再障(SAA)24例,慢性再障(CAA)28例,所有患兒按治療方案不同分為2組,對照組為單用CsA治療,治療組為ATG聯閤CsA治療,比例兩組患兒的療效。結果 CAA組患兒的總有效率為82.1%(23/28),SAA患者總有效率為50.0%(12/24);28例CAA患兒中接受對照組治療27例,總有效率為81.5%(22/27),接受治療組治療1例,總有效率100.0(1/1),兩組有效率比較,差異無統計學意義(P >0.05);24例SAA患兒中接受治療組治療8例,總有效率25.0%(2/8),接受對照組治療16例,總有效率75.0%(12/16),治療組有效率高于對照組,差異具有統計學意義(P <0.05)。結論ATG聯閤CsA治療兒童SAA療效佳,可作為缺乏閤適供體進行造血榦細胞移植患兒的首選治療方式。
목적:관찰항흉선구단백(ATG)연합배포소A(CsA)치료인동재생장애성빈혈(AA)적료효,탐토제고인동AA료효적유효방안。방법회고성분석52례재아원접수정규치료병차문진수방시간초과6개월AA환인적림상자료,기중중형재장(SAA)24례,만성재장(CAA)28례,소유환인안치료방안불동분위2조,대조조위단용CsA치료,치료조위ATG연합CsA치료,비례량조환인적료효。결과 CAA조환인적총유효솔위82.1%(23/28),SAA환자총유효솔위50.0%(12/24);28례CAA환인중접수대조조치료27례,총유효솔위81.5%(22/27),접수치료조치료1례,총유효솔100.0(1/1),량조유효솔비교,차이무통계학의의(P >0.05);24례SAA환인중접수치료조치료8례,총유효솔25.0%(2/8),접수대조조치료16례,총유효솔75.0%(12/16),치료조유효솔고우대조조,차이구유통계학의의(P <0.05)。결론ATG연합CsA치료인동SAA료효가,가작위결핍합괄공체진행조혈간세포이식환인적수선치료방식。
Objective The purpose of the study is to observe the effect of the anti-thymocyte globulinlobulin(ATG)combined with cyclosporine(CsA)on the treatment of children with aplastic anemia(AA).Methods 52 cases with AA in our hospital were analyzed and the patients were folowed up for more than 6 months.Severe aplastic anemia(SAA)in 24 cases and chronic aplastic anemia(CAA)in 28 cases were included.Al the patients were divided into two groups.The experiment group was treated with ATG and CsA.Control group was treated using CsA.Results The total effective rate in CAA patients was 82.1%(23/28).The total effective rate in SAA was 50%(12/24).Effect of CAA group was significantly higher than the SAA group.In the 28 patients with CAA,27 cases were treated in the control group,the total effective rate of which was 81.5%(22/27).One case was in the treatment group,and total effective rate was 100.0%(1/1).The difference between the two groups was not statisticaly significant(P > 0.05).In the 24 patients with SAA,8 cases were in the experiment group and the total effective rate was 25%(2/8).16 cases were in the control group,and the total effective rate 75%(12/16). The effective rate in the treatment group was higher than the control group(P < 0.05).Conclusion ATG combined with CsA is effective in children with SAA.The method could be preferred for the children without suitable donors for hematopoietic stem cel transplantation.