CAJ | 학술논문

目的：探讨瑞舒伐他汀治疗脑梗死合并颈动脉粥样硬化斑块的临床效果。方法选择我院2012年8月～2014年7月收治的脑梗死合并颈动脉粥样斑块患者116例，按照随机数字表法将其分为治疗组和对照组，每组58例，对照组口服拜阿司匹林肠溶片治疗，治疗组在对照组治疗方法的基础上加用瑞舒伐他汀钙治疗。两组均治疗6个月，比较治疗前后两组颈动脉内膜中层厚度（IMT）、颈动脉斑块积分、甘油三酯（TG）、以及胆固醇（TC）水平。结果两组治疗后IMT、颈动脉斑块积分、TG以及TC水平均较治疗前有改善，差异有统计学意义（P<0.05）；治疗组治疗后IMT以及颈动脉斑块积分、TG以及TC水平改善较对照组治疗后更加有效，差异有统计学意义（P<0.05）。结论瑞舒伐他汀钙治疗脑梗死合并颈动脉粥样硬化斑块患者具有治疗效果。
목적：탐토서서벌타정치료뇌경사합병경동맥죽양경화반괴적림상효과。방법선택아원2012년8월～2014년7월수치적뇌경사합병경동맥죽양반괴환자116례，안조수궤수자표법장기분위치료조화대조조，매조58례，대조조구복배아사필림장용편치료，치료조재대조조치료방법적기출상가용서서벌타정개치료。량조균치료6개월，비교치료전후량조경동맥내막중층후도（IMT）、경동맥반괴적분、감유삼지（TG）、이급담고순（TC）수평。결과량조치료후IMT、경동맥반괴적분、TG이급TC수평균교치료전유개선，차이유통계학의의（P<0.05）；치료조치료후IMT이급경동맥반괴적분、TG이급TC수평개선교대조조치료후경가유효，차이유통계학의의（P<0.05）。결론서서벌타정개치료뇌경사합병경동맥죽양경화반괴환자구유치료효과。
Objective To investigate the clinical effect of rosuvastatin in the treatment of cerebral infarction with carotid atherosclerotic plaque.Methods116 cases with cerebral infarction with carotid artery atherosclerotic plaque were divided into the treatment group and the control group according to the random number table method .58 cases in each group.The control group used worship aspirin enteric coated tablets.The treatment group was given with rosuvastatin of atorvastatin calcium on the based of the control group.The two groups were treated for 6 months.The carotid intima media thickness (IMT),carotid plaque integral,triglyceride(TG),and cholesterol(TC)levels of the two groups were compared.Results Compared with before treatment, IMT and carotid artery plaque integral, TG and TC levels in two groups than after treatment were significantly improved,and the difference was statisticaly significant (P< 0.05).IMT and carotid artery plaque integral, TG and TC levels of the treatment group after treatment improved compared with the control group,and the difference was statisticaly significant (P< 0.05).ConclusionThe rosuvastatin in the treatment of cerebral infarction with carotid atherosclerosis plaque patients can achieve remarkable results.