中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2015年
7期
577-580
,共4页
邹会玲%孙宇%乔继冰%戚亚兰%曹长春%刚强%张瑛%王昆%刘超
鄒會玲%孫宇%喬繼冰%慼亞蘭%曹長春%剛彊%張瑛%王昆%劉超
추회령%손우%교계빙%척아란%조장춘%강강%장영%왕곤%류초
新生儿%参考值%促甲状腺素%甲状腺素%三碘甲状腺原氨酸
新生兒%參攷值%促甲狀腺素%甲狀腺素%三碘甲狀腺原氨痠
신생인%삼고치%촉갑상선소%갑상선소%삼전갑상선원안산
Neonate%Reference interval%Thyrotropin%Thyroxine%Triiodothyronine
目的建立宿迁地区健康新生儿甲状腺功能正常参考值。方法入组健康新生儿500名,抽取72 h 足跟血测定足跟血 TSH。入组200名健康新生儿,出生后14 d 抽取静脉血,检测血清 TT3、TT4、TSH、FT3、FT4。同期选取健康成人120名,检测血清 TT3、TT4、TSH、FT3、FT4。结果本地区健康新生儿72 h 足跟血 TSH 参考范围为0.46~6.59 mIU/ L,14 d 血清 TT3、TT4、TSH、FT3、FT4参考范围分别为1.10~2.62 nmol/ L、81.10~158.28 nmol/ L、0.83~6.39 mIU/ L、3.76~6.66 pmol/ L、10.67~22.27 pmol/ L。与成年人相比较,TSH 差别无统计学意义,TT3、TT4、FT3、FT4差异有统计学意义。结论建立健康新生儿甲状腺功能参考范围值有助于了解新生儿出生后的甲状腺功能水平,根据新生儿72 h 足跟血的 TSH 参考值,建议下调初筛先天性甲状腺功能减退症的切点,以减少其临床漏诊率。
目的建立宿遷地區健康新生兒甲狀腺功能正常參攷值。方法入組健康新生兒500名,抽取72 h 足跟血測定足跟血 TSH。入組200名健康新生兒,齣生後14 d 抽取靜脈血,檢測血清 TT3、TT4、TSH、FT3、FT4。同期選取健康成人120名,檢測血清 TT3、TT4、TSH、FT3、FT4。結果本地區健康新生兒72 h 足跟血 TSH 參攷範圍為0.46~6.59 mIU/ L,14 d 血清 TT3、TT4、TSH、FT3、FT4參攷範圍分彆為1.10~2.62 nmol/ L、81.10~158.28 nmol/ L、0.83~6.39 mIU/ L、3.76~6.66 pmol/ L、10.67~22.27 pmol/ L。與成年人相比較,TSH 差彆無統計學意義,TT3、TT4、FT3、FT4差異有統計學意義。結論建立健康新生兒甲狀腺功能參攷範圍值有助于瞭解新生兒齣生後的甲狀腺功能水平,根據新生兒72 h 足跟血的 TSH 參攷值,建議下調初篩先天性甲狀腺功能減退癥的切點,以減少其臨床漏診率。
목적건립숙천지구건강신생인갑상선공능정상삼고치。방법입조건강신생인500명,추취72 h 족근혈측정족근혈 TSH。입조200명건강신생인,출생후14 d 추취정맥혈,검측혈청 TT3、TT4、TSH、FT3、FT4。동기선취건강성인120명,검측혈청 TT3、TT4、TSH、FT3、FT4。결과본지구건강신생인72 h 족근혈 TSH 삼고범위위0.46~6.59 mIU/ L,14 d 혈청 TT3、TT4、TSH、FT3、FT4삼고범위분별위1.10~2.62 nmol/ L、81.10~158.28 nmol/ L、0.83~6.39 mIU/ L、3.76~6.66 pmol/ L、10.67~22.27 pmol/ L。여성년인상비교,TSH 차별무통계학의의,TT3、TT4、FT3、FT4차이유통계학의의。결론건립건강신생인갑상선공능삼고범위치유조우료해신생인출생후적갑상선공능수평,근거신생인72 h 족근혈적 TSH 삼고치,건의하조초사선천성갑상선공능감퇴증적절점,이감소기림상루진솔。
Objective To establish thyrotropin( TSH) and thyroid hormones reference ranges during the neonatal period for the healthy term newborns in Suqian. Methods Blood samples from a heel-prick were collected from 500 healthy newborns 72 hours after birth to determine the level of TSH. 200 healthy newborns were chosen to determine the levels of serum TSH and thyroid hormones on the 14th day of life, and then compared with the results from 120 healthy adults. Results The reference range of TSH at 72 hours after birth was 0. 46-6. 59 mIU/ L. The reference ranges of TT3 , TT4 , TSH, FT3 , FT4 on the 14th day of life were 1. 10-2. 62 nmol/ L, 81. 10-158. 28 nmol/ L, 0. 83-6. 39 mIU/ L, 3. 76-6. 66 pmol/ L, and 10. 67-22. 27 pmol/ L, respectively. There was no significant difference in the interval of TSH between newborns and adluts, whereas there were significant difference in the intervals of TT3 , TT4 , FT3 , and FT4 between the two groups. Conclusions The establishment of TSH and thyroid hormone reference ranges during the neonatal period for the healthy term newborns could improve our understanding of the thyroid function during the neonatal period for the healthy term newborns, and our data suggests lowing the initiatory screening cut-off point of congential hypothyroidism.
