中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2015年
7期
592-595
,共4页
王媛%史慧婷%姜书宁%赵久阳
王媛%史慧婷%薑書寧%趙久暘
왕원%사혜정%강서저%조구양
维生素 D 结合蛋白%糖尿病, 2 型%糖尿病肾病
維生素 D 結閤蛋白%糖尿病, 2 型%糖尿病腎病
유생소 D 결합단백%당뇨병, 2 형%당뇨병신병
Vitamin D binding protein%Diabetes mellitus,type 2%Diabetic nephropathy
目的：检测2型糖尿病患者血清与尿维生素 D 结合蛋白(VDBP)浓度的变化,探讨其临床意义。方法采用 ELISA 法检测102名健康对照组、106例2型糖尿病组患者血清 VDBP、尿 VDBP 与尿肌酐(Cr)比值及尿微量白蛋白与尿肌酐比值(UACR)。将2型糖尿病患者分为血糖控制良好组与血糖控制不佳组,正常白蛋白尿组与微量白蛋白尿组进行分析与比较。结果血清 VDBP 的正常参考上限为60.6μg/ ml,尿 VDBP/ Cr 的正常参考上限7.76 mg/ g。2型糖尿病组血清 VDBP 及尿 VDBP/ Cr 水平显著高于健康对照组[血：(44.83±6.65)μg/ ml 对(330.92±49.28)μg/ ml,尿：(5.55±2.89) mg/ g 对(15.19±6.38) mg/ g,均 P<0.01],其中血糖控制不佳组血清 VDBP 及尿 VDBP/ Cr 水平显著高于血糖控制良好组(P<0.05),微量白蛋白尿组尿 VDBP/ Cr 水平显著高于正常白蛋白尿组(P<0.01)。尿 VDBP/ Cr 对早期2型糖尿病肾病的诊断敏感性为96.4%,特异性为68%,准确性为83%。结论检测血清 VDBP 水平对于评估糖尿病病情有一定参考价值,联合检测尿 VDBP/ Cr 与 UACR 对于糖尿病肾病的早期诊断有重要的临床意义。
目的：檢測2型糖尿病患者血清與尿維生素 D 結閤蛋白(VDBP)濃度的變化,探討其臨床意義。方法採用 ELISA 法檢測102名健康對照組、106例2型糖尿病組患者血清 VDBP、尿 VDBP 與尿肌酐(Cr)比值及尿微量白蛋白與尿肌酐比值(UACR)。將2型糖尿病患者分為血糖控製良好組與血糖控製不佳組,正常白蛋白尿組與微量白蛋白尿組進行分析與比較。結果血清 VDBP 的正常參攷上限為60.6μg/ ml,尿 VDBP/ Cr 的正常參攷上限7.76 mg/ g。2型糖尿病組血清 VDBP 及尿 VDBP/ Cr 水平顯著高于健康對照組[血：(44.83±6.65)μg/ ml 對(330.92±49.28)μg/ ml,尿：(5.55±2.89) mg/ g 對(15.19±6.38) mg/ g,均 P<0.01],其中血糖控製不佳組血清 VDBP 及尿 VDBP/ Cr 水平顯著高于血糖控製良好組(P<0.05),微量白蛋白尿組尿 VDBP/ Cr 水平顯著高于正常白蛋白尿組(P<0.01)。尿 VDBP/ Cr 對早期2型糖尿病腎病的診斷敏感性為96.4%,特異性為68%,準確性為83%。結論檢測血清 VDBP 水平對于評估糖尿病病情有一定參攷價值,聯閤檢測尿 VDBP/ Cr 與 UACR 對于糖尿病腎病的早期診斷有重要的臨床意義。
목적：검측2형당뇨병환자혈청여뇨유생소 D 결합단백(VDBP)농도적변화,탐토기림상의의。방법채용 ELISA 법검측102명건강대조조、106례2형당뇨병조환자혈청 VDBP、뇨 VDBP 여뇨기항(Cr)비치급뇨미량백단백여뇨기항비치(UACR)。장2형당뇨병환자분위혈당공제량호조여혈당공제불가조,정상백단백뇨조여미량백단백뇨조진행분석여비교。결과혈청 VDBP 적정상삼고상한위60.6μg/ ml,뇨 VDBP/ Cr 적정상삼고상한7.76 mg/ g。2형당뇨병조혈청 VDBP 급뇨 VDBP/ Cr 수평현저고우건강대조조[혈：(44.83±6.65)μg/ ml 대(330.92±49.28)μg/ ml,뇨：(5.55±2.89) mg/ g 대(15.19±6.38) mg/ g,균 P<0.01],기중혈당공제불가조혈청 VDBP 급뇨 VDBP/ Cr 수평현저고우혈당공제량호조(P<0.05),미량백단백뇨조뇨 VDBP/ Cr 수평현저고우정상백단백뇨조(P<0.01)。뇨 VDBP/ Cr 대조기2형당뇨병신병적진단민감성위96.4%,특이성위68%,준학성위83%。결론검측혈청 VDBP 수평대우평고당뇨병병정유일정삼고개치,연합검측뇨 VDBP/ Cr 여 UACR 대우당뇨병신병적조기진단유중요적림상의의。
Objective To determine the changes in serum and urine vitamin D binding protein ( VDBP) concentrations in type 2 diabetes, and to explore the clinical significance. Methods The serum and urine VDBP concentrations in 102 healthy individuals and 106 type 2 diabetic patients were determined by ELISA. For analysis and comparison, 106 type 2 diabetic patients were divided into imperfect glycemic control subgroup and perfect glycemic control subgroup, microalbuminuria subgroup and normal albuminuria subgroup. Results The cut-off point of serum VDBP concentrations was 60. 6 μg/ ml and the cut-off point of the urine ratio of VDBP and creatinine was 7. 76 mg/ g, and both were determined according to the upper limit of 97. 5 % credit intervals in 110 healthy individuals. Serum VDBP concentration and the urine ratio of VDBP to creatinine in type 2 diabetic patients were significantly higher than those in the healthy individuals ( P < 0. 01 ), the imperfect glycemic control subgroup had higher serum VDBP concentrations and the urine ratio of VDBP to creatinine than those in the perfect glycemic control subgroup ( P <0. 05). The microalbuminuria subgroup had higher urine ratio of VDBP to creatinine than that in the normal albuminuria subgroup ( P<0. 01). Urine ratio of VDBP to creatinine in diagnosing early diabetic nephropathy had sensitivity of 96. 4 % , specificity of 68 % , and concordance of 83% . Conclusion Detection of serum VDBP levels has some reference value in understanding the state of diabetes. Combined determinations of urine ratio of VDBP to creatinine and ratio of albumin to creatinine have significant clinical value in the early diagnosis of diabetic nephropathy.
