CAJ | 학술논문

目的：总结和评价采用新辅助化疗的方式对于临床治疗中晚期宫颈癌的效果。方法选取我院在2012年10月～2014年10月期间收治的Ⅱb～Ⅲb期巨块型宫颈癌患者60例作为本次研究对象，以观察组和对照组进行划分，每组各30例。观察组患者在接受全子宫切除以及盆腔淋巴结清扫术之前为其进行新辅助化疗，对照组则直接行全子宫切除以及盆腔淋巴结清扫术。对比两组患者治疗效果。结果观察组30例在接受新辅助化疗后，CR有3例，PR有18例，SD有9例，总有效率为70.0％（21/30），无PD病例。患者未出现感染及出血等严重并发症。同时，观察组较对照组而言，具有手术时间短、出血量少的优势，差异具有统计学意义（P<0.05）。结论给予中晚期宫颈癌术前新辅助化疗有利于患者肿瘤的切除，且安全性较好，能够帮助提高患者生活质量。
목적：총결화평개채용신보조화료적방식대우림상치료중만기궁경암적효과。방법선취아원재2012년10월～2014년10월기간수치적Ⅱb～Ⅲb기거괴형궁경암환자60례작위본차연구대상，이관찰조화대조조진행화분，매조각30례。관찰조환자재접수전자궁절제이급분강림파결청소술지전위기진행신보조화료，대조조칙직접행전자궁절제이급분강림파결청소술。대비량조환자치료효과。결과관찰조30례재접수신보조화료후，CR유3례，PR유18례，SD유9례，총유효솔위70.0％（21/30），무PD병례。환자미출현감염급출혈등엄중병발증。동시，관찰조교대조조이언，구유수술시간단、출혈량소적우세，차이구유통계학의의（P<0.05）。결론급여중만기궁경암술전신보조화료유리우환자종류적절제，차안전성교호，능구방조제고환자생활질량。
Objective To summarize and evaluate the effect of neoadjuvant chemotherapy in the treatment of middle and advanced cervical cancer.Methods Admitted IIB~III B bulky cervical cancer patients 60 cases as the research object in our hospital from October 2012 October 2014.The observation group and the control group were divided, each with 30 cases . Patients in the observation group received neoadjuvant chemotherapy before and after hysterectomy and pelvic lymph node dissection, while the control group underwent total hysterectomy and pelvic lymph node dissection. The effect of neoadjuvant chemotherapy before operation and the operation of the two groups were compared.Results In the observation group, 30 patients received neoadjuvant chemotherapy. 3 cases of CR, 18 cases of PR, 9 cases of SD, the total effective rate was 70% (21/30), no PD cases. The patients did not appear to have serious complications such as infection and bleeding. At the same time, the observation group compared with the control group, with the advantages of short operation time, less bleeding, the difference was statisticaly significant (P< 0.05).Conclusion Neoadjuvant chemotherapy in advanced cervical cancer patients is helpful to tumor resection, and the safety is good.It can help improve the quality of life of patients.