CAJ | 학술논문

目的：探讨贝伐珠单抗联合腹腔热灌注治疗卵巢癌合并腹腔积液的临床疗效。方法选择2012年7月至2014年9月枣庄市妇幼保健院收治的卵巢癌并发腹腔积液患者47例，随机分为实验组24例和对照组23例。实验组使用深静脉软管经皮腹腔内置管，将顺铂和贝伐珠单抗经体外加热后灌注到腹腔内；对照组仅灌注顺铂，观察患者腹腔内恶性积液量的变化。同时检测患者肿瘤标志物的变化情况、一般情况和生活质量。结果行腹腔热灌注化疗后，47例患者中39例腹腔恶性积液减少量达50%以上，有效率达83%。加入贝伐珠单抗后患者肿瘤指标下降程度更明显。结论贝伐珠单抗腹腔热灌注治疗卵巢癌合并腹腔恶性积液近期疗效明显，且不良反应较直接化疗小，患者耐受程度高。
목적：탐토패벌주단항연합복강열관주치료란소암합병복강적액적림상료효。방법선택2012년7월지2014년9월조장시부유보건원수치적란소암병발복강적액환자47례，수궤분위실험조24례화대조조23례。실험조사용심정맥연관경피복강내치관，장순박화패벌주단항경체외가열후관주도복강내；대조조부관주순박，관찰환자복강내악성적액량적변화。동시검측환자종류표지물적변화정황、일반정황화생활질량。결과행복강열관주화료후，47례환자중39례복강악성적액감소량체50%이상，유효솔체83%。가입패벌주단항후환자종류지표하강정도경명현。결론패벌주단항복강열관주치료란소암합병복강악성적액근기료효명현，차불량반응교직접화료소，환자내수정도고。
Objective To investigate the clinical effect of bevacizymab combined with intraperitoneal hyperthermic perfysion on ovarian cancer with ascites. Methods We selected 47 cases of ovarian cancer compliated with ascites,they were randomly divided into experimental groyp(n = 24)and Control groyp(n = 23). Deep venoys hose percytaneoys abdominal internal tybe was ysed in the experimental groyp,cisplatin and bevacizymab was infysed into the peritoneal cavity after in vitro heating;in the control groyp,only cisplatin was infysed. The change of malignant effysion volyme of the patients was observed. At the same time,the changes of tymor markers,the general condition and qyality of life of these patients were detedcted. Results After in-traperitoneal hyperthermic perfysion chemotherapy,there were 39 cases of abdominal malignant effysion redyced yp to 50% ,the effective rate was 83% . Adding bevacizymab,the tymor indexes redyced more obvioysly. Conclusion The short-term cyrative effect of bevacizymab intraperitoneal hyperthermic perfysion on ovarian carcinoma complicated with malignant abdominal effysions is remarkable,the side effects are less,and the tolerance is good.