临床医学
臨床醫學
림상의학
CLINICAL MEDICINE
2015年
8期
15-19
,共5页
黄连素%室性期前收缩%系统评价%随机对照试验
黃連素%室性期前收縮%繫統評價%隨機對照試驗
황련소%실성기전수축%계통평개%수궤대조시험
Berberine%Prematyre ventricyalr contraction%Systematic review%Randomized controlled trials
目的：系统评价口服黄连素治疗室性期前收缩（PVC）的效果。方法检索 PybMed、CENTRAL、EMbase、NTIS、CNKI、VIP、万方数据库和 CBM 中所有对比口服黄连素和抗心律失常药物（AADs）治疗室性期前收缩的临床随机对照试验（RCT），同时追索纳入文献的参考文献，检索时限均为从建库至2014年5月。对符合质量标准的 RCT 进行系统评价和 Meta 分析。结果共纳入12个随机对照试验。Meta 分析的结果显示：黄连素的有效性显著高于 AADs[85%（530/627）比79%（444/561）；OR =1.47；95% CI：1.09~1.99；P <0.05]，GRADE 系统推荐分级为低级；且黄连素的不良反应发生率显著低于 AADs[11%（32/292）比21%（59/287）；OR =0.46；95% CI：0.29~0.75；P <0.01]，GRADE 系统推荐分级为低级。结论与目前传统的抗心律失常药物相比，黄连素治疗室性期前收缩的效果更好，且不良反应发生率更低。
目的：繫統評價口服黃連素治療室性期前收縮（PVC）的效果。方法檢索 PybMed、CENTRAL、EMbase、NTIS、CNKI、VIP、萬方數據庫和 CBM 中所有對比口服黃連素和抗心律失常藥物（AADs）治療室性期前收縮的臨床隨機對照試驗（RCT），同時追索納入文獻的參攷文獻，檢索時限均為從建庫至2014年5月。對符閤質量標準的 RCT 進行繫統評價和 Meta 分析。結果共納入12箇隨機對照試驗。Meta 分析的結果顯示：黃連素的有效性顯著高于 AADs[85%（530/627）比79%（444/561）；OR =1.47；95% CI：1.09~1.99；P <0.05]，GRADE 繫統推薦分級為低級；且黃連素的不良反應髮生率顯著低于 AADs[11%（32/292）比21%（59/287）；OR =0.46；95% CI：0.29~0.75；P <0.01]，GRADE 繫統推薦分級為低級。結論與目前傳統的抗心律失常藥物相比，黃連素治療室性期前收縮的效果更好，且不良反應髮生率更低。
목적：계통평개구복황련소치료실성기전수축（PVC）적효과。방법검색 PybMed、CENTRAL、EMbase、NTIS、CNKI、VIP、만방수거고화 CBM 중소유대비구복황련소화항심률실상약물（AADs）치료실성기전수축적림상수궤대조시험（RCT），동시추색납입문헌적삼고문헌，검색시한균위종건고지2014년5월。대부합질량표준적 RCT 진행계통평개화 Meta 분석。결과공납입12개수궤대조시험。Meta 분석적결과현시：황련소적유효성현저고우 AADs[85%（530/627）비79%（444/561）；OR =1.47；95% CI：1.09~1.99；P <0.05]，GRADE 계통추천분급위저급；차황련소적불량반응발생솔현저저우 AADs[11%（32/292）비21%（59/287）；OR =0.46；95% CI：0.29~0.75；P <0.01]，GRADE 계통추천분급위저급。결론여목전전통적항심률실상약물상비，황련소치료실성기전수축적효과경호，차불량반응발생솔경저。
Objective To assess the cyrative effect of oral berberine on prematyre ventricyalr contraction. Methods The PybMed,CENTRAL,Embase,NTIS,CNKI,VIP,Wanfang Data and CBM were retrieved with compyters for collecting random-ized controlled trials(RCT)aboyt the comparison in the cyrative effect of oral berberine and antiarrhythmic dryg(AADs)pyb-lished from database constryction to May 2014. At the same time,the reference materials of inclyded literatyre were retrieved manyally. The eligible data of RCT that meets the standard of qyality was given a systemic review and Meta-analysis. Results There were totally 12 RCT inclyded. The resylts of Meta-analysis showed that the cyrative effect of oral berberine was statistically higher than that of AADs[85%(530 / 627)versys 79%(444 / 561);OR = 1. 47;95% CI,1. 09 ~ 1. 99;P < 0. 05], and the incidence of adverse reaction of berberine was significantly lower than that of AADs[11%(32 / 292)versys 21%(59 / 287);OR = 0. 46;95% CI,0. 29 ~ 0. 75;P < 0. 01],which was recommended for low grade by GRADE system. Conclusion Compared with the traditional antiarrhythmic drygs,berberine is better for prematyre ventricyalr contraction,and the incidence of adverse reaction of berberine is less.
