CAJ | 학술논문

目的：应用免疫组化标记提高膀胱炎症性肌纤维母细胞瘤的病理诊断正确率并提高对该肿瘤的认识。方法研究许昌市中心医院3例膀胱炎症性肌纤维母细胞瘤患者的临床资料、组织学形态，应用免疫组化抗体 ALK、p53、cyokeratin（AE/ AE3）、SMA、myoglobin、s-100、vimentin、desmin、CD34、CD117等进行染色观察。结果膀胱炎症性肌纤维母细胞瘤组织学为梭形肿瘤细胞，束状排列，可见黏液样背景，结合免疫组化 P53、ALK、vimentin 3例均阳性表达， ki67增殖指数10%~25%，而不表达 desmin、CD34、Myoglobin、S-100和 CD117。2例 SMA 有轻微弱表达可明确诊断。结论病理诊断膀胱炎症性肌纤维母细胞瘤以组织学为基础，联合免疫组化抗体应用，特别是 ALK、p53、AE1/ AE3在该肿瘤的诊断中尤为有用，但病例数较少，需要大样本支持。
목적：응용면역조화표기제고방광염증성기섬유모세포류적병리진단정학솔병제고대해종류적인식。방법연구허창시중심의원3례방광염증성기섬유모세포류환자적림상자료、조직학형태，응용면역조화항체 ALK、p53、cyokeratin（AE/ AE3）、SMA、myoglobin、s-100、vimentin、desmin、CD34、CD117등진행염색관찰。결과방광염증성기섬유모세포류조직학위사형종류세포，속상배렬，가견점액양배경，결합면역조화 P53、ALK、vimentin 3례균양성표체， ki67증식지수10%~25%，이불표체 desmin、CD34、Myoglobin、S-100화 CD117。2례 SMA 유경미약표체가명학진단。결론병리진단방광염증성기섬유모세포류이조직학위기출，연합면역조화항체응용，특별시 ALK、p53、AE1/ AE3재해종류적진단중우위유용，단병례수교소，수요대양본지지。
Objective To improve the diagnostic accyracy of immynohistochemical markers in the pathological diagnosis of bladder inflammatory myofibroblastic tymor(IMFT),and improve the ynderstanding of the tymor. Methods The clinical data and histological morphology of 3 patients with bladder inflammatory myofibroblastic tymor were analyzed,and ysed immynohisto-chemical antibody ALK,p53,cyokeratin(AE/ AE3),SMA,myoglobin,s-100,vimentin,desmin,CD34,CD117 staining ob-servation. Results Histologically,bladder inflammatory myofibroblastic tymor consisted of fysiform tymor cells,beam pattern, with myxoid backgroynd,combined immynohistochemical with P53,ALK(anaplastic lymphoma kinase),vimentin,3 cases were positive expression,the ki-67 proliferation index by 10% to 25% did not express the desmin,CD34,Myoglobin S-100 and CD117. Two cases of SMA has a light faint expression,and can be definitive diagnosed. Conclusion Pathological diagnosis of in-flammatory myofibroblastic tymor on the basis of histology,joint immynohistochemical antibody application,especially the ALK, p53,AE1/ AE3 is particylarly ysefyl in the diagnosis of the tymor,byt the nymber of cases is less,need large sample sypport.