CAJ | 학술논문

目的：在本研究中，我们评估了一种新型褪黑素受体激动剂Neu-P12对坐骨神经慢性结扎(CCI)模型大鼠神经性疼痛的改善作用。方法：SD大鼠坐骨神经慢性结扎手术后第12天行机械性痛阈测定，检测指标大鼠缩足反应阈值(PWT),分别于溶媒、吗啡(10mg/kg)或Neu-P12(30,100或300mg/kg)注射前0分钟(基础值)及注射后30、60、90、120及180分钟时行PWT检测。结果：与假手术组比较，CCI模型组大鼠PWT值显著性降低；与CCI模型组比较，吗啡处理组、100及300mg/kg Neu-P12组大鼠PWT值显著性升高。此外，100及300mg/kg Neu-P12组大鼠PWT值显著性高于30mg/kg Neu-P12组大鼠；300mg/kg Neu-P12组大鼠PWT值显著性高于100mg/kg Neu-P12组大鼠。结论：新型褪黑素受体激动剂Neu-P12剂量依赖地改善坐骨神经慢性结扎模型大鼠神经性疼痛。
목적：재본연구중，아문평고료일충신형퇴흑소수체격동제Neu-P12대좌골신경만성결찰(CCI)모형대서신경성동통적개선작용。방법：SD대서좌골신경만성결찰수술후제12천행궤계성통역측정，검측지표대서축족반응역치(PWT),분별우용매、마배(10mg/kg)혹Neu-P12(30,100혹300mg/kg)주사전0분종(기출치)급주사후30、60、90、120급180분종시행PWT검측。결과：여가수술조비교，CCI모형조대서PWT치현저성강저；여CCI모형조비교，마배처리조、100급300mg/kg Neu-P12조대서PWT치현저성승고。차외，100급300mg/kg Neu-P12조대서PWT치현저성고우30mg/kg Neu-P12조대서；300mg/kg Neu-P12조대서PWT치현저성고우100mg/kg Neu-P12조대서。결론：신형퇴흑소수체격동제Neu-P12제량의뢰지개선좌골신경만성결찰모형대서신경성동통。
Objective In the present study, we assessed the potential antinociceptive effects of a novel melatonin receptor agonist Neu-P12 in the neuropathic pain induced by chronic constriction injury (CCI) in rats.Methods Twelve days after surgery, mechanical hyperalgesia was assessed before and 30 min, 60 min, 90 min, 120 min, 180 min after vehicle, morphine (10 mg/kg) or Neu-P12 (30, 100 and 300 mg/kg) administration.Results Compared with the sham rats, the CCI rats showed less levels of the paw withdrawal threshold (PWT). Compared with the CCI rats, rats with morphine at 10 mg/kg showed more levels of the PWT. Neu-P12 increased dose-dependently the levels of the PWT.Conclusion The novel melatonin receptor agonist Neu-P12, like morphine, exert antinociceptive activities in the CCI model in rats.