脑与神经疾病杂志
腦與神經疾病雜誌
뇌여신경질병잡지
JOURNAL OF BRAIN AND NERVOUS DISEASES
2015年
4期
285-288,289
,共5页
同型半胱氨酸%β2 微球蛋白%脑梗死%ROC 曲线
同型半胱氨痠%β2 微毬蛋白%腦梗死%ROC 麯線
동형반광안산%β2 미구단백%뇌경사%ROC 곡선
Homocysteine%β2 microglobulin%Cerebral infarction%ROC curve
目的研究同型半胱氨酸（Hcy）、β2微球蛋白（β2 MG）与脑梗死诊断和预后监测的临床价值。方法分析本院87例脑梗死患者及91例体检中心健康人员的血清 Hcy、β2 MG 的水平及临床资料，对脑梗死各期与正常对照组比较及梗死灶大小、梗死神经功能缺损程度之间的水平含量比较，并应用受试者工作特性<br> （ ROC）曲线，对血清Hcy、β2 MG水平含量进行分析，评价在脑梗死患者的临床诊断与监测价值。结果87例脑梗死患者血清Hcy、β2 MG水平含量显著高于91例健康体检人员，且差异有统计学意义（ P＜0．01）；脑梗死急性期与恢复期比较，差异有统计学意义（P＜0．05）；恢复期与正常对照组比较，差异有统计学意义（P＜0．05）；脑梗死不同大小病灶之间比较，差异有统计学意义（ P＜0．05）；脑梗死神经功能缺损程度之间比较，差异有统计学意义（ P＜0．05）。根据ROC曲线确定Hcy的临界值为10．9μg? L－1，诊断灵敏度为96．3％，特异度为84．1％，ROC曲线下面积（ AUC）为0．931。确定β2 MG的临界值为2．7mg? L－1，诊断灵敏度为91．5％，特异度为82．7％，ROC曲线下面积（ AUC）为0．875。结论血清Hcy、β2 MG均作为脑梗死的一项独立危险因素，在临床诊断中有较高的灵敏性和特异性。
目的研究同型半胱氨痠（Hcy）、β2微毬蛋白（β2 MG）與腦梗死診斷和預後鑑測的臨床價值。方法分析本院87例腦梗死患者及91例體檢中心健康人員的血清 Hcy、β2 MG 的水平及臨床資料，對腦梗死各期與正常對照組比較及梗死竈大小、梗死神經功能缺損程度之間的水平含量比較，併應用受試者工作特性<br> （ ROC）麯線，對血清Hcy、β2 MG水平含量進行分析，評價在腦梗死患者的臨床診斷與鑑測價值。結果87例腦梗死患者血清Hcy、β2 MG水平含量顯著高于91例健康體檢人員，且差異有統計學意義（ P＜0．01）；腦梗死急性期與恢複期比較，差異有統計學意義（P＜0．05）；恢複期與正常對照組比較，差異有統計學意義（P＜0．05）；腦梗死不同大小病竈之間比較，差異有統計學意義（ P＜0．05）；腦梗死神經功能缺損程度之間比較，差異有統計學意義（ P＜0．05）。根據ROC麯線確定Hcy的臨界值為10．9μg? L－1，診斷靈敏度為96．3％，特異度為84．1％，ROC麯線下麵積（ AUC）為0．931。確定β2 MG的臨界值為2．7mg? L－1，診斷靈敏度為91．5％，特異度為82．7％，ROC麯線下麵積（ AUC）為0．875。結論血清Hcy、β2 MG均作為腦梗死的一項獨立危險因素，在臨床診斷中有較高的靈敏性和特異性。
목적연구동형반광안산（Hcy）、β2미구단백（β2 MG）여뇌경사진단화예후감측적림상개치。방법분석본원87례뇌경사환자급91례체검중심건강인원적혈청 Hcy、β2 MG 적수평급림상자료，대뇌경사각기여정상대조조비교급경사조대소、경사신경공능결손정도지간적수평함량비교，병응용수시자공작특성<br> （ ROC）곡선，대혈청Hcy、β2 MG수평함량진행분석，평개재뇌경사환자적림상진단여감측개치。결과87례뇌경사환자혈청Hcy、β2 MG수평함량현저고우91례건강체검인원，차차이유통계학의의（ P＜0．01）；뇌경사급성기여회복기비교，차이유통계학의의（P＜0．05）；회복기여정상대조조비교，차이유통계학의의（P＜0．05）；뇌경사불동대소병조지간비교，차이유통계학의의（ P＜0．05）；뇌경사신경공능결손정도지간비교，차이유통계학의의（ P＜0．05）。근거ROC곡선학정Hcy적림계치위10．9μg? L－1，진단령민도위96．3％，특이도위84．1％，ROC곡선하면적（ AUC）위0．931。학정β2 MG적림계치위2．7mg? L－1，진단령민도위91．5％，특이도위82．7％，ROC곡선하면적（ AUC）위0．875。결론혈청Hcy、β2 MG균작위뇌경사적일항독립위험인소，재림상진단중유교고적령민성화특이성。
Objective To study homocysteine (Hcy), β2 microglobulin (β2 MG) the clinical value of senile cerebral infarction diagnosis and prognosis monitoring.Methods Retrospective analysis of hospital 87 cases of patients with cerebral infarction and 91 cases of examination center health staff serum Hcy levels and clinical dataβ2 MG, senile cerebral infarction and normal control group and the infarct size, infarct nerve function the defect level between the level of content and application of receiver operating characteristic ( ROC) curve, senile cerebral infarction serum the Hcy, β2 MG level content analysis and evaluation of the value of the clinical diagnosis and monitoring.Results The 87 patients with cerebral infarction in patients with Hcy β2 MG level content were significantly higher than the 91 cases of elderly healthy volunteers, and the difference was statistically significant (P<0.01); elderly patients with acute cerebral infarction and convalescent difference was statistically significant P<0.05; convalescence and normal control group, the difference was statistically significant (P <0.05); senile cerebral infarction comparison between the different size of lesions, the difference was statistically significant (P<0.05); senile cerebral infarction nerve function defect between the degree of comparison, the difference was statistically significant, P <0.05; under the ROC curve the Hcy 's critical value 10.9μg ? L-1 , the diagnostic sensitivity 96.3%,Specificity for 84.1%.ROC area under the curve (AUC) for0.931; Determine β2 MG the critical value of 2.7mg? L-1 , the diagnostic sensitivity91.5% ,Specificity for 82.7%, The area under the ROC curve (AUC) for the 0.875.Conclusion Serum Hcy and β2 MG are as an independent risk factor for cerebral infarction with high sensitivity and specificity in clinical diagnosis.
