中华消化杂志
中華消化雜誌
중화소화잡지
Chinese Journal of Digestion
2015年
6期
377-381
,共5页
季尚玮%屈昊%刘春雷%张永贵%王江滨
季尚瑋%屈昊%劉春雷%張永貴%王江濱
계상위%굴호%류춘뢰%장영귀%왕강빈
螺杆菌,幽门%糖尿病,2 型%胃肌轻瘫%根除治疗
螺桿菌,幽門%糖尿病,2 型%胃肌輕癱%根除治療
라간균,유문%당뇨병,2 형%위기경탄%근제치료
Helicobacter pylori%Diabetes mellitus,type 2%Gastroparesis%Eradication therapy
目的:探讨2型糖尿病患者 H .pylori 感染现状及其对糖尿病胃轻瘫的影响。方法采用前瞻性临床病例对照研究方法,纳入2011年1月至2013年12月住院的125例2型糖尿病患者和同期的142名无消化不良症状的健康对照者。调查两组的 H .pylori 感染状况及糖尿病患者胃轻瘫的发生率。将2型糖尿病患者按照病程进行分组,分析各组合并胃轻瘫和 H .pylori 感染情况。对所有感染H .pylori的2型糖尿病患者和健康对照者进行 H .pylori 根除治疗,比较两组的根除率,并比较2型糖尿病患者治疗前后胃轻瘫症状的改善情况。统计学方法采用卡方检验。结果2型糖尿病组的H .pylori感染率为66.4%(83/125),高于健康对照组的51.4%(73/142),差异有统计学意义(χ2=5.549,P <0.05)。糖尿病病程<10年,10~20年和>20年患者的胃轻瘫发生率分别为33.8%(27/80)、47.1%(16/34)、8/11,差异有统计学意义(χ2=6.554,P <0.05);且合并胃轻瘫患者的H .pylori感染率为78.4%(40/51),高于未合并胃轻瘫患者的58.1%(43/74),差异有统计学意义(χ2=4.716,P <0.05)。2型糖尿病患者的 H .pylori 根除率为68.7%(57/83),低于健康对照组的87.8%(36/41),差异有统计学意义(χ2=4.385,P <0.05)。2型糖尿病患者 H .pylori 根除治疗前的上腹胀痛、早饱和厌食的发生率分别为75.9%(63/83)、66.3%(55/83)和67.5%(56/83),根除治疗后分别为44.6%(37/83)、37.3%(31/83)和39.8%(33/83),差异均有统计学意义(χ2=15.720、12.764、11.724, P 均<0.01)。结论2型糖尿病患者 H .pylori 感染率升高,且糖尿病胃轻瘫的发生与 H .pylori 感染有关。2型糖尿病患者的 H .pylori 根除率较低,H .pylori 根除治疗可有效改善糖尿病胃轻瘫患者的消化不良症状。
目的:探討2型糖尿病患者 H .pylori 感染現狀及其對糖尿病胃輕癱的影響。方法採用前瞻性臨床病例對照研究方法,納入2011年1月至2013年12月住院的125例2型糖尿病患者和同期的142名無消化不良癥狀的健康對照者。調查兩組的 H .pylori 感染狀況及糖尿病患者胃輕癱的髮生率。將2型糖尿病患者按照病程進行分組,分析各組閤併胃輕癱和 H .pylori 感染情況。對所有感染H .pylori的2型糖尿病患者和健康對照者進行 H .pylori 根除治療,比較兩組的根除率,併比較2型糖尿病患者治療前後胃輕癱癥狀的改善情況。統計學方法採用卡方檢驗。結果2型糖尿病組的H .pylori感染率為66.4%(83/125),高于健康對照組的51.4%(73/142),差異有統計學意義(χ2=5.549,P <0.05)。糖尿病病程<10年,10~20年和>20年患者的胃輕癱髮生率分彆為33.8%(27/80)、47.1%(16/34)、8/11,差異有統計學意義(χ2=6.554,P <0.05);且閤併胃輕癱患者的H .pylori感染率為78.4%(40/51),高于未閤併胃輕癱患者的58.1%(43/74),差異有統計學意義(χ2=4.716,P <0.05)。2型糖尿病患者的 H .pylori 根除率為68.7%(57/83),低于健康對照組的87.8%(36/41),差異有統計學意義(χ2=4.385,P <0.05)。2型糖尿病患者 H .pylori 根除治療前的上腹脹痛、早飽和厭食的髮生率分彆為75.9%(63/83)、66.3%(55/83)和67.5%(56/83),根除治療後分彆為44.6%(37/83)、37.3%(31/83)和39.8%(33/83),差異均有統計學意義(χ2=15.720、12.764、11.724, P 均<0.01)。結論2型糖尿病患者 H .pylori 感染率升高,且糖尿病胃輕癱的髮生與 H .pylori 感染有關。2型糖尿病患者的 H .pylori 根除率較低,H .pylori 根除治療可有效改善糖尿病胃輕癱患者的消化不良癥狀。
목적:탐토2형당뇨병환자 H .pylori 감염현상급기대당뇨병위경탄적영향。방법채용전첨성림상병례대조연구방법,납입2011년1월지2013년12월주원적125례2형당뇨병환자화동기적142명무소화불량증상적건강대조자。조사량조적 H .pylori 감염상황급당뇨병환자위경탄적발생솔。장2형당뇨병환자안조병정진행분조,분석각조합병위경탄화 H .pylori 감염정황。대소유감염H .pylori적2형당뇨병환자화건강대조자진행 H .pylori 근제치료,비교량조적근제솔,병비교2형당뇨병환자치료전후위경탄증상적개선정황。통계학방법채용잡방검험。결과2형당뇨병조적H .pylori감염솔위66.4%(83/125),고우건강대조조적51.4%(73/142),차이유통계학의의(χ2=5.549,P <0.05)。당뇨병병정<10년,10~20년화>20년환자적위경탄발생솔분별위33.8%(27/80)、47.1%(16/34)、8/11,차이유통계학의의(χ2=6.554,P <0.05);차합병위경탄환자적H .pylori감염솔위78.4%(40/51),고우미합병위경탄환자적58.1%(43/74),차이유통계학의의(χ2=4.716,P <0.05)。2형당뇨병환자적 H .pylori 근제솔위68.7%(57/83),저우건강대조조적87.8%(36/41),차이유통계학의의(χ2=4.385,P <0.05)。2형당뇨병환자 H .pylori 근제치료전적상복창통、조포화염식적발생솔분별위75.9%(63/83)、66.3%(55/83)화67.5%(56/83),근제치료후분별위44.6%(37/83)、37.3%(31/83)화39.8%(33/83),차이균유통계학의의(χ2=15.720、12.764、11.724, P 균<0.01)。결론2형당뇨병환자 H .pylori 감염솔승고,차당뇨병위경탄적발생여 H .pylori 감염유관。2형당뇨병환자적 H .pylori 근제솔교저,H .pylori 근제치료가유효개선당뇨병위경탄환자적소화불량증상。
Objective To investigate the prevalence of Helicobacter pylori (H .pylori)infection in type 2 diabetic patients and its effects on diabetic gastroparesis.Methods Prospective clinical case-control study was applied.From January 2011 to December 2013,125 hospitalized patients with type 2 diabetes and 142 healthy controls without dyspeptic symptoms were enrolled.The prevalence of H .pylori infection and the incidence of gastroparesis in 125 patients with diabetes were investigated in both two groups.The patients with type 2 diabetes were divided into groups according to the course of the disease,and the prevalence of gastroparesis and H .pylori infection of each group were analyzed.The patients with type 2 diabetes and healthy controls confirmed with H .pylori infection were treated with eradication therapy,the rate of eradication of two groups was compared.The improved symptoms of gastroparesis before and after eradication therapy of patients with type 2 diabetes were compared.The chi-square test was performed for statistical analysis.Results The prevalence of H .pylori infection in type 2 diabetic patients was 66.4%(83/125),which was significantly higher than that of healthy control group (51 .4%,73/142 )(χ2 =5 .549,P <0.05).The prevalence of gastroparesis in diabetic patients with the disease course less than 10 years,10 to 20 years and more than 20 years was 33.8% (27/80 ),47.1 % (16/34 )and 8/11 , respectively.The difference was statistically significant (χ2 = 6.554,P < 0.05).The prevalence of H .pylori infection in patients with gastroparesis was 78.4% (40/51 ),which was significantly higher than that of patients without gastroparesis (58.1 %,43/74)(χ2 =4.716,P <0.05).The eradication rate of H .pylori infection in patients with type 2 diabetes was 68.7% (57/83),which was lower than that of healthy control group (87.8%,36/41),and the difference was statistically significant (χ2 =4.385 ,P <0.05).The incidence of epigastric pain and distension,early satiety and apocleisis before H .pylori eradication in type 2 diabetes patients was 75 .9% (63/83 ),66.3% (55/83 )and 67.5 % (56/83 ), respectively,while after eradication which was 44.6%(37/83),37.3%(31/83)and 39.8%(33/83)after eradication,respectively.The differences were statistically significant (χ2 =15 .720,12.764 and 11 .724;all P <0.01).Conclusions The prevalence of H .pylori infection is significantly higher in type 2 diabetic patients,and gastroparesis in type 2 diabetic patients may be correlated with H .pylori infection.The eradication rate in type 2 diabetic patients was lower,and H .pylori eradication therapy can efficiently improve the symptoms of dyspepsia in diabetic patients with gastroparesis.