CAJ | 학술논문

目的：比较沙美特罗替卡松粉吸入剂与氨茶碱片治疗女性缓解期慢性阻塞性肺疾病（COPD）的效果及其对 IL‐6、IL‐8的影响。方法选取2012年1月至2014年6月川北医学院附属医院收治的女性缓解期 COPD患者160例，按照随机数字表法随机分为观察组和对照组各80例。观察组吸入沙美特罗替卡松粉吸入剂，对照组口服氨茶碱片进行治疗。比较2组治疗后的效果、深吸气量（IC）、1 s 用力呼气容积（FEV1）、用力肺活量（FVC）、第一秒用力呼气容积占预计值的百分比（FEV1％）等肺功能指标及白细胞介素（IL）‐6、IL‐8水平。结果观察组总有效率87．5％高于对照组72．5％，差异有统计学意义（P＜0．05）；观察组在治疗后 IC 、FEV1、FVC 、FEV1％等指标升高明显，呼吸困难指数（TDI）、6 min 步行距离（6MWD）也更高，差异有统计学意义（P ＜0．05）；2组在治疗前 IL‐6、IL‐8水平比较差异无统计学差异（P ＞0．05），2组治疗后 IL‐6、IL‐8水平均较治疗前降低，但治疗后观察组 IL‐6、IL‐8水平下降更明显，差异有统计学意义（P＜0．05）。结论沙美特罗替卡松粉吸入剂与氨茶碱片治疗女性缓解期COPD 均呈现高效结果，但相对来说沙美特罗替卡松吸入治疗效果更佳，对呼吸困难缓解程度更好。
목적：비교사미특라체잡송분흡입제여안다감편치료녀성완해기만성조새성폐질병（COPD）적효과급기대 IL‐6、IL‐8적영향。방법선취2012년1월지2014년6월천북의학원부속의원수치적녀성완해기 COPD환자160례，안조수궤수자표법수궤분위관찰조화대조조각80례。관찰조흡입사미특라체잡송분흡입제，대조조구복안다감편진행치료。비교2조치료후적효과、심흡기량（IC）、1 s 용력호기용적（FEV1）、용력폐활량（FVC）、제일초용력호기용적점예계치적백분비（FEV1％）등폐공능지표급백세포개소（IL）‐6、IL‐8수평。결과관찰조총유효솔87．5％고우대조조72．5％，차이유통계학의의（P＜0．05）；관찰조재치료후 IC 、FEV1、FVC 、FEV1％등지표승고명현，호흡곤난지수（TDI）、6 min 보행거리（6MWD）야경고，차이유통계학의의（P ＜0．05）；2조재치료전 IL‐6、IL‐8수평비교차이무통계학차이（P ＞0．05），2조치료후 IL‐6、IL‐8수평균교치료전강저，단치료후관찰조 IL‐6、IL‐8수평하강경명현，차이유통계학의의（P＜0．05）。결론사미특라체잡송분흡입제여안다감편치료녀성완해기COPD 균정현고효결과，단상대래설사미특라체잡송흡입치료효과경가，대호흡곤난완해정도경호。
Objective To compare the efficacy of Salmeterol fluticasone propionate inhalation and Aminophyl‐line Tablets treating female chronic obstructive pulmonary disease(COPD) with remission and the influence on IL‐6 , IL‐8 levels .Methods During January 2012 to June 2014 ,160 cases of female remission of COPD patients were select‐ed and were divided into observation group and control group with 80 cases in each group according to digital meth‐od .The observation group inhaled salmeterol fluticasone propionate powder for inhalation ,while the control group o‐ral aminophylline tablets for treatment .The curative effect and IC ,FEV1 ,FVC ,FEV1% lung function index and IL‐6 ,IL‐8 levels were compared between the two groups .Results Observation group total effective rate 87 .5% was higher than the control group 72 .5% ,the difference was statistically significant(P < 0 .05) .Observation group IC , FEV1 and FVC ,FEV1% index after treatment increased obviously ,TDI ,6 MWDS is also higher ,the difference was statistically significant(P< 0 .05) .In the two groups before treatment IL‐6 ,IL‐8 levelsare of no statistical difference (P> 0 .05) ,the two groups after treatment IL‐6 ,IL‐8 levelswere reduced ,the observation group after treatment IL‐6 , IL‐8 levels drop were more obvious ,the difference was statistically significant(P< 0 .05) .Conclusion Salmeterol flu‐ticasone propionate inhalation and aminophylline tablets in the treatment of female remission of COPD showed a high efficient results ,but the relative effect of salmeterol fluticasone propionate inhalation therapy effect is better ,the de‐gree of dyspnea alleviated better .