CAJ | 학술논문

目的：观察急性脑梗死患者阿司匹林抵抗发生情况及影响急性脑梗死患者阿司匹林抵抗的相关因素。方法2010年10月－2011年11月在我院神经内科住院治疗的176例急性脑梗死患者作为研究对象，根据入院前是否服用阿司匹林分为两组：已服组32例，未服组144例。入院后两组均服拜阿司匹林100mg? d－1，连服1w 后用全血电阻法监测两组阿司匹林抵抗发生情况，，分为阿司匹林抵抗组和阿司匹林敏感组，分析两组在性别、年龄、血常规、生化指标、心电图、超声心动图、颈动脉彩超及基础疾病等方面的差异。结果176例脑梗死患者中发生阿司匹林抵抗27例，发生率为15．3％，发生阿司匹林半抵抗97例，发生率为55．1％。阿司匹林抵抗发生情况与入院前是否服用阿司匹林无明显关系（P＞0．05）。阿司匹林抵抗组在性别、血小板计数、白细胞计数、糖化血红蛋白与阿司匹林敏感组比较差异有统计学意义（P＜0．05）。结论服用阿司匹林的急性脑梗死患者阿司匹林抵抗是完全存在的。发生阿司匹林抵抗可能与性别、血小板数、白细胞数及糖化血红蛋白等因素有关。
목적：관찰급성뇌경사환자아사필림저항발생정황급영향급성뇌경사환자아사필림저항적상관인소。방법2010년10월－2011년11월재아원신경내과주원치료적176례급성뇌경사환자작위연구대상，근거입원전시부복용아사필림분위량조：이복조32례，미복조144례。입원후량조균복배아사필림100mg? d－1，련복1w 후용전혈전조법감측량조아사필림저항발생정황，，분위아사필림저항조화아사필림민감조，분석량조재성별、년령、혈상규、생화지표、심전도、초성심동도、경동맥채초급기출질병등방면적차이。결과176례뇌경사환자중발생아사필림저항27례，발생솔위15．3％，발생아사필림반저항97례，발생솔위55．1％。아사필림저항발생정황여입원전시부복용아사필림무명현관계（P＞0．05）。아사필림저항조재성별、혈소판계수、백세포계수、당화혈홍단백여아사필림민감조비교차이유통계학의의（P＜0．05）。결론복용아사필림적급성뇌경사환자아사필림저항시완전존재적。발생아사필림저항가능여성별、혈소판수、백세포수급당화혈홍단백등인소유관。
Objective To investigate the prevalence of aspirin resistance in the patients with acute cerebral infarction and the correlative factors of aspirin resistance in the patients with acute cerebral infarction who had taken aspirin regularly.Methods All of 176 patients with acute cerebral infarction were from the Department of Neurology, Suzhou Municipal Hospital during from October 2010 to November 2011.According to they had been admitted to hospital whether or not oral aspirin divided into two groups:had medicated 31 cases, unmedicated 145 cases.All patients in the groups taken aspirin regularly (100mg? d-1 ) for a week, then observed the prevalence of aspirin resistance in two groups.Analysed the results of the index of blood test,sex, clinical disease and so on between aspirin resistance and aspirin sensitive in the patients.Results There were 27 cases with aspirin resistance in 176 patients of acute cerebral infarction, the incidence was 15.3% and 97 cases with aspirin semi-resistance in 176 patients of acute cerebral infarction, the incidence was 55.1%.The incidence rate of aspirin resistance in the patients with acute cerebral infarction has no obvious relationship to whether or not oral aspirin before they had been admitted to hospital.Aspirin resistant were most likely to be women, the platelet count, white blood cell count and glycosylated hemoglobin levels of aspirin resistance were on the high side compared with aspirin sensitive .The difference was remarkable (P<0.05).Conclusion Aspirin resistance really existed in the patients with acute cerebral infarction who had taken aspirin regularily.The event of aspirin resistance and aspirin semi-resistance are likely correlated with sex, platelets, white blood cells and glycosylated hemoglobin.