CAJ | 학술논문

目的：了解珠海市人类免疫缺陷病毒（HIV）、梅毒螺旋体（TP）和丙型肝炎病毒（HCV）在吸毒人群、男性性病门诊人群（MSP）和男男同性人群（MSM ）中的感染情况，为制定不同人群的防控策略提供实验室依据。方法采集3类人群血样，采用酶联免疫吸附试验（ELISA）进行初步抗体检测，HIV 抗体阳性采用蛋白免疫印迹法（WB）进行确证，梅毒抗体阳性采用甲苯胺红不加热血清试验（TRUST ）和梅毒螺旋体明胶颗粒凝集试验（TPPA）进行确证，HCV 阳性者再进行复检确认，并对结果进行统计分析。结果珠海市吸毒人群、MSP 人群、MSM 人群HIV 阳性率分别为为0．61％、1．50％、5．97％；HCV 阳性率分别为70．45％、0．25％、1．49％；TP 阳性率分别为4．66％、22．50％、15．42％，感染率为2．63％、16．25％、9．95％。吸毒人群 HCV 感染明显高于其他人群，MSM 人群HIV 感染率则明显高于其他2类人群，3类人群中梅毒感染率均高于健康人群，各人群中，梅毒以隐性感染为主。结论3类男性人群均为 HIV 和梅毒感染的高危人群，HCV 感染以静脉吸毒人群为主，传染病防控应对不同人群采取不同的健康教育和行为干预，提高人们对 HIV 、TP 和 HCV 等疾病的认知水平，防止传染病在高危人群中传播以及从高危人群向一般人群扩散。
목적：료해주해시인류면역결함병독（HIV）、매독라선체（TP）화병형간염병독（HCV）재흡독인군、남성성병문진인군（MSP）화남남동성인군（MSM ）중적감염정황，위제정불동인군적방공책략제공실험실의거。방법채집3류인군혈양，채용매련면역흡부시험（ELISA）진행초보항체검측，HIV 항체양성채용단백면역인적법（WB）진행학증，매독항체양성채용갑분알홍불가열혈청시험（TRUST ）화매독라선체명효과립응집시험（TPPA）진행학증，HCV 양성자재진행복검학인，병대결과진행통계분석。결과주해시흡독인군、MSP 인군、MSM 인군HIV 양성솔분별위위0．61％、1．50％、5．97％；HCV 양성솔분별위70．45％、0．25％、1．49％；TP 양성솔분별위4．66％、22．50％、15．42％，감염솔위2．63％、16．25％、9．95％。흡독인군 HCV 감염명현고우기타인군，MSM 인군HIV 감염솔칙명현고우기타2류인군，3류인군중매독감염솔균고우건강인군，각인군중，매독이은성감염위주。결론3류남성인군균위 HIV 화매독감염적고위인군，HCV 감염이정맥흡독인군위주，전염병방공응대불동인군채취불동적건강교육화행위간예，제고인문대 HIV 、TP 화 HCV 등질병적인지수평，방지전염병재고위인군중전파이급종고위인군향일반인군확산。
Objective To understand the HIV ,TP and HCV infection situation among drug users ,male STDs patients(MSP) and men who have sex with men(MSM ) in Zhuhai City to provide the laboratory basis for formula‐ting the prevention and control strategy in different populations .Methods The blood samples were collected from these three groups .Enzyme‐linked immunosorbent assay(ELISA) was used for conducting the preliminary antibody detection ,and the anti‐HIV antibody positive was confirmed by Western blot(WB) ,the anti‐TP antibody positive was confirmed by toluidine red untreated serum test (TRUST )/treponema pallidum passive particle agglutination test (TPPA) and the the anti‐HCV antibody positive was confirmed by re‐detection .Results The HIV positive rate a‐mong the drug users ,MSP and MSM groups in Zhuhai City were 0 .61% ,1 .50% and 5 .97% respectively ;The HCV positive rates were 70 .45% ,0 .25% and 1 .49% respectively ;the TP positive rates were 4 .66% ,22 .50% and 15 .42% respectively .The infection rates of TP were 2 .63% ,16 .25% and 9 .95% respectively .The HCV positive rate in the DUs group was higher than that in other two groups ,the HIV positive rate in the MSM group was higher than that in other two groups .The TP infection rates from above three groups were totally higher than that in normal population .TP was dominated by inapparent infection .Conclusion These three male groups all are the high risk pop‐ulation of HIV and TP ,and the HCV infection is almost from intraveneous drug group .The prevention and control of infectious diseases should adopt different behavior interventions and health educations to improve the cognitive level on HIV ,HCV and TP ,and prevent the transmission of infectious diseases in high‐risk populations and their spread from high risk population to general population .