CAJ | 학술논문

目的：探讨不同类型人乳头瘤病毒（HPV ）多重感染与宫颈病变的相关性。方法应用基因芯片技术对200例宫颈病变患者石蜡组织标本进行24种 HPV 基因型进行检测，以组织病理学诊断作为宫颈病变确诊的金标准为依据。结果200例标本中，HPV 总感染率为51．50％（103／200），其中慢性宫颈炎、鳞状上皮内低度病变（CIN1）、鳞状上皮内高度病变（CIN3）和宫颈鳞状细胞癌的 HPV 感染率分别为22／57（38．60％）、12／33（36．36％）、44／81（54．32％）、25／29（86．21％），与宫颈病变密切相关（P＜0．01）；不同宫颈病变中单一 HPV 感染率明显高于多重 HPV 感染率（P＜0．05）；高危型单一感染组 HPV 感染率与宫颈病变不相关（P＞0．05），多重感染、高危型感染、高危型多重感染、低危型多重感染、高低混合型多重感染的各组 HPV 感染率在不同级别宫颈病变差异有统计学意义（P＜0．05）。结论 HPV 感染率与宫颈病变的不同程度密切相关，持续高危型感染 HPV 和多重感染 HPV 是加重宫颈病变的重要因素。
목적：탐토불동류형인유두류병독（HPV ）다중감염여궁경병변적상관성。방법응용기인심편기술대200례궁경병변환자석사조직표본진행24충 HPV 기인형진행검측，이조직병이학진단작위궁경병변학진적금표준위의거。결과200례표본중，HPV 총감염솔위51．50％（103／200），기중만성궁경염、린상상피내저도병변（CIN1）、린상상피내고도병변（CIN3）화궁경린상세포암적 HPV 감염솔분별위22／57（38．60％）、12／33（36．36％）、44／81（54．32％）、25／29（86．21％），여궁경병변밀절상관（P＜0．01）；불동궁경병변중단일 HPV 감염솔명현고우다중 HPV 감염솔（P＜0．05）；고위형단일감염조 HPV 감염솔여궁경병변불상관（P＞0．05），다중감염、고위형감염、고위형다중감염、저위형다중감염、고저혼합형다중감염적각조 HPV 감염솔재불동급별궁경병변차이유통계학의의（P＜0．05）。결론 HPV 감염솔여궁경병변적불동정도밀절상관，지속고위형감염 HPV 화다중감염 HPV 시가중궁경병변적중요인소。
Objective To explore the relationship between different types of human papilomavirus(HPV) mul‐tiple infection and cervical lesions .Methods The gene chip technology was applied to detect 24 types of HPV geno‐types in the paraffin tissue specimens from 200 patients with cervical lesions ,the histopathological diagnosis was used as the gold standard of cervical lesion diagnosis .Results In 200 specimens ,the total infection rate of HPV was 51 .50% (103/200) ,in which the HPV infection rates in chronic cervictis ,low‐CIN1 ,high‐CIN3 and squamous cell carcinoma were 22/57(38 .60% ) ,12/33(36 .36% ) ,44/81(54 .32% ) and 25/29(86 .21% ) ,respectively ,and were cor‐related with the cervical lesions(P< 0 .01) ;In different cervical lesions ,single HPV infection was significantly higher than multiple HPV infection(P < 0 .05) ;The HPV infection rate in the high‐risk type single HPV infection group had no correlated with the cervical lesions(P > 0 .05) .The HPV infection rates in the multiple infection ,high‐risk HPV infection ,high‐risk HPV multiple infection ,low‐risk HPV multiple infection ,and high and low risk mixed HPV infection groups had statistically significant differences among different grades of cervical lesions(P< 0 .05) .Conclu‐sion The infection rate of HPV is correlated with the different degrees of cervical lesion .The persistent high‐risk HPV infection and multiple HPV infection are the important factors for aggravating the cervical lesions .