CAJ | 학술논문

打破肝硬化作为慢性肝病的最终阶段的单一病理框架，重构肝硬化多个阶段、多种方式动态演变的病理学亚分类概念，具有重要的理论和实践意义。初步研究提示，肝脏组织学参数纤维隔厚度、结节大小和基于纤维隔厚度、结节大小的 La?nnec 亚分期系统、Kumar 亚分类系统以及基于数字图像分析的胶原面积比对肝硬化门脉高压和临床分期有一定的预测作用。在同病因和大样本基础上，以疾病发展和回归为参照，探索和验证肝硬化病理学亚分类及其相关组织学参数的有效性，应当是今后肝硬化病理学亚分类研究的主流方向。
타파간경화작위만성간병적최종계단적단일병리광가，중구간경화다개계단、다충방식동태연변적병이학아분류개념，구유중요적이론화실천의의。초보연구제시，간장조직학삼수섬유격후도、결절대소화기우섬유격후도、결절대소적 La?nnec 아분기계통、Kumar 아분류계통이급기우수자도상분석적효원면적비대간경화문맥고압화림상분기유일정적예측작용。재동병인화대양본기출상，이질병발전화회귀위삼조，탐색화험증간경화병이학아분류급기상관조직학삼수적유효성，응당시금후간경화병이학아분류연구적주류방향。
Breaking single pathological frame of cirrhosis as end stage of chronic liver disease, and reconstructing the pathological sub-classification of cirrhosis as dynamic evolution with multiple stages and multiple forms, which has theoretical and practical importance. Preliminary findings suggest that the fibrous septum thickness and nodule size of histological parameters of liver tissue, and La?nnec sub-stage system and Kumar sub-classification system based on the fibrous septum thickness and nodule size, collagen proportionate area based on digital image analysis, have predictive power for portal hypertension and clinical staging of cirrhosis. In basis of same cause and large sample, and taking disease progression and regression as the references, to explore and validate the effectiveness of pathological sub-classification of cirrhosis and the related histological parameters of liver tissue, which should be the main stream of future.