CAJ | 학술논문

肠道微生物生态系统是哺乳动物体内最复杂和最大的微生态系统。然而现今大量抗生素的使用使得肠道菌群发生巨大改变，一部分菌群受到冲击而被破坏，甚至发展为难辨梭菌感染。粪菌移植作为一种特殊的器官移植，和可以重建肠道菌群的疗法重新被临床所关注，但这一治疗方法并未成为常规治疗手段，因其操作的特殊性并不被很多临床工作者及患者所接受。如今随着粪菌移植研究的逐渐深入，其在难治性难辨梭状芽孢杆菌感染、炎性肠病、肠易激综合征、慢性疲劳综合征以及一些与代谢性疾病相关的肠道外疾病中得到使用。现结合国内外相关文献，对粪菌移植的起源、适应证、机制、制作过程、现状及未来等研究进展作一综述，旨在为粪菌移植这一治疗方法更好地应用于临床提供借鉴。
장도미생물생태계통시포유동물체내최복잡화최대적미생태계통。연이현금대량항생소적사용사득장도균군발생거대개변，일부분균군수도충격이피파배，심지발전위난변사균감염。분균이식작위일충특수적기관이식，화가이중건장도균군적요법중신피림상소관주，단저일치료방법병미성위상규치료수단，인기조작적특수성병불피흔다림상공작자급환자소접수。여금수착분균이식연구적축점심입，기재난치성난변사상아포간균감염、염성장병、장역격종합정、만성피로종합정이급일사여대사성질병상관적장도외질병중득도사용。현결합국내외상관문헌，대분균이식적기원、괄응증、궤제、제작과정、현상급미래등연구진전작일종술，지재위분균이식저일치료방법경호지응용우림상제공차감。
Intestinal microbial ecosystem is the most complex and the largest micro-ecosystem of the mammals. The use of antibiotics can lead to a lot of major changes of the flora, making the intestinal flora damaged and impacted, even developing Clostridium difficile infection. Fecal microbiota transplantation (FMT) as a special organ transplant therapy, which can rebuild the intestinal flora, has raised the clinical concerns. It has been used in the refractory Clostridium difficile, inflammatory bowel disease, irritable bowel syndrome, chronic fatigue syndrome, and some non-intestinal diseases related to the metabolic disorders. But this method of treatment has not become a normal treatment, and many clinicians and patients can not accept it. This paper reviews relevant literature in terms of origin, indications, mechanism, production process, current situation and future research, and provide a reference for the clinical application of the treatment of fecal microbiota transplantation.