东南国防医药
東南國防醫藥
동남국방의약
JOURNAL OF SOUTHEAST CHINA NATIONAL DEFENCE MEDICAL SCIENCE
2015年
4期
362-364
,共3页
王苏梦%吴嘉%牛冬梅%汪俊军
王囌夢%吳嘉%牛鼕梅%汪俊軍
왕소몽%오가%우동매%왕준군
N-末端B型钠尿肽前体%红细胞分布宽度%C反应蛋白%急性冠脉综合征
N-末耑B型鈉尿肽前體%紅細胞分佈寬度%C反應蛋白%急性冠脈綜閤徵
N-말단B형납뇨태전체%홍세포분포관도%C반응단백%급성관맥종합정
NT-proBNP%RDW%CRP%acute coronary syndrome
目的:探讨联合检测血清N-末端B型钠尿肽前体( NT-proBNP)、C-反应蛋白( CRP)及红细胞分布宽度( RDW)3种标志物在急性冠脉综合征( ACS)的水平变化并探讨其相关性。方法检测69例ACS患者、90例稳定型冠心病( CAD)患者和67例体检健康者血清NT-proBNP、全血CRP和RDW水平,分析3个指标的相关性。结果 NT-proBNP、RDW和CRP水平在ACS患者中水平分别为520.50(216.65~1360.50) pmol/L、13.60(12.90~14.40)%、13.00(7.05~50.50) mg/L,明显高于CAD患者:20.89(8.91~47.03)pmol/L、13.25(12.80~13.80)%、3.00(1.00~5.25)mg/L和健康人群4.06(2.10~13.01)pmol/L、13.00(12.70~13.60)%、1.00(0.50~3.30) mg/L。在ACS患者中,NT-proBNP和RDW、CRP均有明显的相关性(r=0.403,r=0.533,P<0.01),而在CAD患者中,NT-proBNP仅与RDW相关(r=0.373,P<0.01)。结论 ACS患者NT-proBNP、CRP和RDW的水平明显升高并具有相关性,3项联合检测有助于ACS的临床诊断。
目的:探討聯閤檢測血清N-末耑B型鈉尿肽前體( NT-proBNP)、C-反應蛋白( CRP)及紅細胞分佈寬度( RDW)3種標誌物在急性冠脈綜閤徵( ACS)的水平變化併探討其相關性。方法檢測69例ACS患者、90例穩定型冠心病( CAD)患者和67例體檢健康者血清NT-proBNP、全血CRP和RDW水平,分析3箇指標的相關性。結果 NT-proBNP、RDW和CRP水平在ACS患者中水平分彆為520.50(216.65~1360.50) pmol/L、13.60(12.90~14.40)%、13.00(7.05~50.50) mg/L,明顯高于CAD患者:20.89(8.91~47.03)pmol/L、13.25(12.80~13.80)%、3.00(1.00~5.25)mg/L和健康人群4.06(2.10~13.01)pmol/L、13.00(12.70~13.60)%、1.00(0.50~3.30) mg/L。在ACS患者中,NT-proBNP和RDW、CRP均有明顯的相關性(r=0.403,r=0.533,P<0.01),而在CAD患者中,NT-proBNP僅與RDW相關(r=0.373,P<0.01)。結論 ACS患者NT-proBNP、CRP和RDW的水平明顯升高併具有相關性,3項聯閤檢測有助于ACS的臨床診斷。
목적:탐토연합검측혈청N-말단B형납뇨태전체( NT-proBNP)、C-반응단백( CRP)급홍세포분포관도( RDW)3충표지물재급성관맥종합정( ACS)적수평변화병탐토기상관성。방법검측69례ACS환자、90례은정형관심병( CAD)환자화67례체검건강자혈청NT-proBNP、전혈CRP화RDW수평,분석3개지표적상관성。결과 NT-proBNP、RDW화CRP수평재ACS환자중수평분별위520.50(216.65~1360.50) pmol/L、13.60(12.90~14.40)%、13.00(7.05~50.50) mg/L,명현고우CAD환자:20.89(8.91~47.03)pmol/L、13.25(12.80~13.80)%、3.00(1.00~5.25)mg/L화건강인군4.06(2.10~13.01)pmol/L、13.00(12.70~13.60)%、1.00(0.50~3.30) mg/L。재ACS환자중,NT-proBNP화RDW、CRP균유명현적상관성(r=0.403,r=0.533,P<0.01),이재CAD환자중,NT-proBNP부여RDW상관(r=0.373,P<0.01)。결론 ACS환자NT-proBNP、CRP화RDW적수평명현승고병구유상관성,3항연합검측유조우ACS적림상진단。
Objective This study was to investigate plasma NT-proBNP, CRP and RDW levels in acute coronary syndrome ( ACS) and stable CAD patients and to evaluate the relationship of them.Methods Plasma NT-proBNP, red cell distribution width ( RDW) and C-reactive protein ( CRP) levels were determined in 69 ACS, 90 stable CAD patients and 67 controls.The correlation an-alyses and multiple linear regression analyses were performed.Results Plasma NT-proBNP, RDW and CRP levels show 20.50 (216. 65-1360.50)pmol/L, 13.60 (12.90-14.40)%, 13.00 (7.05-50.50)mg/L respectively, they were significantly elevated than patients with CAD 20.89 (8.91-47.03)pmol/L, 13.25 (12.80-13.80)%, 3.00 (1.00-5.25)mg/L and controls 4.06 (2.10-13.01)pmol/L, 13.00 (12.70-13.60)%, 1.00 (0.50-3.30) mg/L.NT-proBNP levels were positively correlated with CRP and RDW in ACS patients (r=0.403, r=0.533, P<0.01), and only RDW were positively correlated with NT-proBNP levels in sta-ble CAD patients(r=0.373, P<0.01).Conclusion Plasma NT-proBNP, CRP and RDW levels were significantly higher in ACS patients and elevated NT-proBNP levels were independently associated with RDW, CRP in ACS.