CAJ | 학술논문

目的：观察a1肾上腺素能受体阻滞剂萘哌地尔片联合复方利多卡因乳膏治疗慢性非细菌性前列腺炎合并早泄的临床疗效。方法120例早泄患者以萘哌地尔片（25 mg，每晚睡前服用1次）、局部涂抹复方利多卡因乳膏治疗，疗程8周。治疗前后用前列腺液常规、前列腺炎症状评分、尿流动力学检查、患者平均阴道内射精潜伏期、性生活满意度、每周性交频率等为评估指标观察疗效。结果治疗8周后，美国国立卫生研究院慢性前列腺炎症状指数（ National Institute of Health Chronic Prostatitis Symptom Index，NIH-CPSI）评分较治疗前分别平均降低12．5，症状尺度评分平均降低8．3，疼痛与不适评分平均降低6．7，排尿症状评分平均降低3．0，生活质量评分平均降低4．1，白细胞计数平均降低15．8个／高倍视野（ high power field，HP）；治疗前后最大尿道闭合压（MUCP）、最大尿道压（MUP）和残余尿量（RU）明显降低（P＜0.05），分别为（687．4±133．5）Pa与（508．6±109．5）Pa、（909．4±140.2）Pa与（702．5±123．8）Pa、（51．0±14．0）mL与（8．0±5．0）mL；平均尿流率（Qave）和最大尿流率（Qmax）明显提高（P＜0.05），分别为（8．2±3．8）mL／s与（11．8±2．9）mL／s、（15．4±5．9） mL／s与（20.8±4．8）mL／s；患者射精潜伏期、患者性交满意度、配偶性交满意度、每周性交频率分别由（0.56±0.35） min、（6．2±1．0）次／周、（4．9±1．0）次／周、（1．0±0.4）次／周提高到（3．79±1．61） min、（10.0±1．7）次／周、（9．1±1．2）次／周、（2．6±0.4）次／周。治疗过程中不良事件发生率1．67％。结论萘哌地尔片联合复方利多卡因乳膏治疗慢性非细菌性前列腺炎合并早泄，疗效满意，临床上值得推广使用。
목적：관찰a1신상선소능수체조체제내고지이편연합복방리다잡인유고치료만성비세균성전렬선염합병조설적림상료효。방법120례조설환자이내고지이편（25 mg，매만수전복용1차）、국부도말복방리다잡인유고치료，료정8주。치료전후용전렬선액상규、전렬선염증상평분、뇨류동역학검사、환자평균음도내사정잠복기、성생활만의도、매주성교빈솔등위평고지표관찰료효。결과치료8주후，미국국립위생연구원만성전렬선염증상지수（ National Institute of Health Chronic Prostatitis Symptom Index，NIH-CPSI）평분교치료전분별평균강저12．5，증상척도평분평균강저8．3，동통여불괄평분평균강저6．7，배뇨증상평분평균강저3．0，생활질량평분평균강저4．1，백세포계수평균강저15．8개／고배시야（ high power field，HP）；치료전후최대뇨도폐합압（MUCP）、최대뇨도압（MUP）화잔여뇨량（RU）명현강저（P＜0.05），분별위（687．4±133．5）Pa여（508．6±109．5）Pa、（909．4±140.2）Pa여（702．5±123．8）Pa、（51．0±14．0）mL여（8．0±5．0）mL；평균뇨류솔（Qave）화최대뇨류솔（Qmax）명현제고（P＜0.05），분별위（8．2±3．8）mL／s여（11．8±2．9）mL／s、（15．4±5．9） mL／s여（20.8±4．8）mL／s；환자사정잠복기、환자성교만의도、배우성교만의도、매주성교빈솔분별유（0.56±0.35） min、（6．2±1．0）차／주、（4．9±1．0）차／주、（1．0±0.4）차／주제고도（3．79±1．61） min、（10.0±1．7）차／주、（9．1±1．2）차／주、（2．6±0.4）차／주。치료과정중불량사건발생솔1．67％。결론내고지이편연합복방리다잡인유고치료만성비세균성전렬선염합병조설，료효만의，림상상치득추엄사용。
Objective To observe the effectiveness of the α1 blocker naftopidil and compound lidocaine cream in the treat-ment of chronic nonbacterial prostatitis( CNP) with premature ejaculation( PE) .Methods 120 cases of patients who had been diag-nosed as CNP complicated with PE were treated with naftopidil ( once 25 mg, once a day before sleeping ) and compound lidocaine cream for 8 weeks.The effectiveness of the drug were observed by comparing Prostatic secretion examination ( EPS) , chronic prostatitis symptomindex ( CPSI) , Urodynamics, Intravaginal ejaculatory latency time( IELT) , the intercourse satisfaction and the mean of coitus-es per week obtained before and after the treatment.Results After 8 weeks'medication, total score of NIH-CPSI, symptom score, pain score, voiding symptoms, the quality of life, white cell count in all patients before and after treatment by an average of 12.5 points, 8.3 points, 6.7 points, 3.0 points, 4.1 points, 15.8/HP.The MUCP (687.4 ±133.5 vs 508.6 ±109.5), MUP (909.4 ± 140.2 vs 702.5 ±123.8), RU (51.0 ±14.0 vs 8.0 ±5.0), Qave (8.2 ±3.8 vs 11.8 ±2.9) and Qmax (15.4 ±5.9 vs 20.8 ± 4.8) were significant different (P<0.05).The outcome of the mean IELT, the sexual intercourse satisfaction (SIS), the patients'partners'sexual activity satisfaction(partners'SIS), the mean number of coituses per week (NC/w) in all patients increased from 0.56 ±0.35, 6.2 ±1.0, 4.9 ±1.0, 1.0 ±0.4 to 3.79 ±1.61, 10.0 ±1.7, 9.1 ±1.2, 2.6 ±0.4.Only 1 patient (1.67%) experi-enced the adverse event of dizziness.Conclusion Naftopidil and compound lidocaine cream are both effective and safe in the treat-ment of CNP complicated with PE which indicated that it is worthy of application widely.