国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2015年
16期
2389-2391
,共3页
慢性丙型肝炎%IL-17%肝硬化%肝纤维化
慢性丙型肝炎%IL-17%肝硬化%肝纖維化
만성병형간염%IL-17%간경화%간섬유화
Chronic C hepatitis%Interleukin-17%Liver cirrhosis%Liver fibrosis
目的 探讨Th17细胞因子在丙型肝炎慢性化中的作用.方法 用酶联免疫吸附法检测38例慢性丙型肝炎、30例丙肝后肝硬化和20例健康人群血清IL-17的水平.结果 慢丙肝组、肝硬化组患者IL-17水平明显高于正常对照组(P＜0.05),两组患者之间比较IL-17水平随着病情的发展逐渐升高:丙肝后硬化组＞慢性丙型肝炎组(P＜0.05).结论 IL-17水平可反映HCV感染者肝脏损伤程度及预后,可作为其判断指标.
目的 探討Th17細胞因子在丙型肝炎慢性化中的作用.方法 用酶聯免疫吸附法檢測38例慢性丙型肝炎、30例丙肝後肝硬化和20例健康人群血清IL-17的水平.結果 慢丙肝組、肝硬化組患者IL-17水平明顯高于正常對照組(P＜0.05),兩組患者之間比較IL-17水平隨著病情的髮展逐漸升高:丙肝後硬化組＞慢性丙型肝炎組(P＜0.05).結論 IL-17水平可反映HCV感染者肝髒損傷程度及預後,可作為其判斷指標.
목적 탐토Th17세포인자재병형간염만성화중적작용.방법 용매련면역흡부법검측38례만성병형간염、30례병간후간경화화20례건강인군혈청IL-17적수평.결과 만병간조、간경화조환자IL-17수평명현고우정상대조조(P＜0.05),량조환자지간비교IL-17수평수착병정적발전축점승고:병간후경화조＞만성병형간염조(P＜0.05).결론 IL-17수평가반영HCV감염자간장손상정도급예후,가작위기판단지표.
Objective To explore the role of Th 17 cytokine IL-17 in the pathogenesis and progress of liver fibrosis in patients with chronic HCV infection.Methods 38 patients with chronic hepatitis C (CHC),30 patients with chronic liver cirrhosis (LC) and 20 healthy controls were selected,whose serum IL-17 was detected by enzyme-linked immunosorbent assay (ELISA).Results IL-17 level in CHC group and LC group were higher than that in control group (P＜0.05).IL-17 level in LC group was higher than that in CHC group (P＜0.05),associated with Child-pugh score.Conclusion IL-17 may indicate the severity and prognosis of patients with chronic HCV infection,which can mark the degree of liver fibrosis.
