皮肤性病诊疗学杂志
皮膚性病診療學雜誌
피부성병진료학잡지
DIAGNOSIS AND THERAPY JOURNAL OF DERMATO-VENEREOLOGY
2015年
4期
281-284
,共4页
吉苏云%臧志军%马寒%袁立燕%戚世玲%王宇%白顺%谷梅%杨斌
吉囌雲%臧誌軍%馬寒%袁立燕%慼世玲%王宇%白順%穀梅%楊斌
길소운%장지군%마한%원립연%척세령%왕우%백순%곡매%양빈
Wnt5a%Sfrp5%银屑病%肥胖
Wnt5a%Sfrp5%銀屑病%肥胖
Wnt5a%Sfrp5%은설병%비반
Wnt5a%Sfrp5%Psoriasis%Obesity
目的：探讨Wnt5a、Sfrp5水平与寻常型银屑病及肥胖的关系。方法：收集正常人和寻常型银屑病血浆，分为非肥胖正常人组、肥胖正常人组、非肥胖银屑病组和肥胖银屑病组，每组各20例。采用ELISA检测血浆Wnt5a及Sfrp5水平，比较组间血浆 Wnt5a及Sfrp5水平并作相关分析。结果：与非肥胖正常人组血浆Wnt5a水平（0.082±0.054）ng／mL比较，非肥胖银屑病患者[（0.105±0.049）ng／mL]和肥胖银屑病患者[（0.320±0.155）ng／mL]血浆Wnt5a水平明显升高（P值均＜0.01），肥胖正常人群组[（0.105±0.049）ng／mL]无明显改变。非肥胖正常人组血浆Sfrp5水平为（75.11±19.72）ng／mL，肥胖正常人组[（55.85±13.65） ng／mL]、非肥胖银屑病组[（58.09±16.78） ng／mL]及肥胖银屑病组[（52.21±15.72）ng／mL]血浆Sfrp5水平较其降低（P值均＜0.05）。结论：Wnt5a及Sfrp5可能与寻常型银屑病及肥胖发生发展相关，是联系银屑病和代谢综合征之间的重要介质。
目的：探討Wnt5a、Sfrp5水平與尋常型銀屑病及肥胖的關繫。方法：收集正常人和尋常型銀屑病血漿，分為非肥胖正常人組、肥胖正常人組、非肥胖銀屑病組和肥胖銀屑病組，每組各20例。採用ELISA檢測血漿Wnt5a及Sfrp5水平，比較組間血漿 Wnt5a及Sfrp5水平併作相關分析。結果：與非肥胖正常人組血漿Wnt5a水平（0.082±0.054）ng／mL比較，非肥胖銀屑病患者[（0.105±0.049）ng／mL]和肥胖銀屑病患者[（0.320±0.155）ng／mL]血漿Wnt5a水平明顯升高（P值均＜0.01），肥胖正常人群組[（0.105±0.049）ng／mL]無明顯改變。非肥胖正常人組血漿Sfrp5水平為（75.11±19.72）ng／mL，肥胖正常人組[（55.85±13.65） ng／mL]、非肥胖銀屑病組[（58.09±16.78） ng／mL]及肥胖銀屑病組[（52.21±15.72）ng／mL]血漿Sfrp5水平較其降低（P值均＜0.05）。結論：Wnt5a及Sfrp5可能與尋常型銀屑病及肥胖髮生髮展相關，是聯繫銀屑病和代謝綜閤徵之間的重要介質。
목적：탐토Wnt5a、Sfrp5수평여심상형은설병급비반적관계。방법：수집정상인화심상형은설병혈장，분위비비반정상인조、비반정상인조、비비반은설병조화비반은설병조，매조각20례。채용ELISA검측혈장Wnt5a급Sfrp5수평，비교조간혈장 Wnt5a급Sfrp5수평병작상관분석。결과：여비비반정상인조혈장Wnt5a수평（0.082±0.054）ng／mL비교，비비반은설병환자[（0.105±0.049）ng／mL]화비반은설병환자[（0.320±0.155）ng／mL]혈장Wnt5a수평명현승고（P치균＜0.01），비반정상인군조[（0.105±0.049）ng／mL]무명현개변。비비반정상인조혈장Sfrp5수평위（75.11±19.72）ng／mL，비반정상인조[（55.85±13.65） ng／mL]、비비반은설병조[（58.09±16.78） ng／mL]급비반은설병조[（52.21±15.72）ng／mL]혈장Sfrp5수평교기강저（P치균＜0.05）。결론：Wnt5a급Sfrp5가능여심상형은설병급비반발생발전상관，시련계은설병화대사종합정지간적중요개질。
Objective:To explore the relationship between plasma Wnt5a and Sfrp5 levels and obese of patients with psoriasis vulgaris.Methods:20 non-obese controls, 20 obese controls, 20 non-obese psoriasis patients and 20 obese psoriasis patients were enrolled in this study.Plasma Wnt5a and Sfrp5 concentrations were measured through enzyme-linked immunosorbent assay ( ELISA) and compared.Results:Wnt5a was significantly higher in non-obese patients with psori-asis ( 0.105 ±0.049 ng/mL ) and obese psoriasis patients ( 0.320 ±0.155 ng/mL ) compared with non-obese healthy controls (0.082 ±0.054 ng/mL) (both P<0.01).Sfrp5 was significant-ly lower in obese healthy men (55.85 ±13.65 ng/mL, P=0.001) and non-obese patients with psoriasis vulgaris ( 58.09 ±16.78 ng/mL, P=0.01 ) compared with non-obese healthy controls (75.11 ±19.72 ng/mL).Conclusion:Wnt5a and Sfrp5 may play a role in psoriasis vulgaris and obesity, and they may be an important media of psoriasis and metabolic syndrome.
