CAJ | 학술논문

目的：探讨p57、p53和p63蛋白在鉴别诊断水肿性流产（HA），部分性葡萄胎（PHM）和完全性葡萄胎（CHM）的价值。方法：采用免疫组织化学染色法检测HA（n＝21）、PHM（n＝28）和CHM（n＝32）石蜡组织切片中p57、p53和p63的表达。结果：HA、PHM和CHM组织中，p57蛋白的阳性表达率分别为90．5％（19／21）、100％（28／28）和0．0％（0／32），PHM和CHM组间有明显差异（P＜0．01）；p53蛋白的阳性表达率分别为28．3％（5／21）、71．4％（20／28）和87．5％（28／32），HA、PHM组相比也有明显差异（P＜0．01）；p63蛋白的阳性表达率分别为81．0％（17／21）、89．3％（25／28）和87．5％（28／32），各组间均无统计学差异。结论：以常规石蜡切片的病理形态特征为基础，结合免疫组化检测p57、p53和p63的结果，对鉴别水肿性流产和葡萄胎具有重要价值。
목적：탐토p57、p53화p63단백재감별진단수종성유산（HA），부분성포도태（PHM）화완전성포도태（CHM）적개치。방법：채용면역조직화학염색법검측HA（n＝21）、PHM（n＝28）화CHM（n＝32）석사조직절편중p57、p53화p63적표체。결과：HA、PHM화CHM조직중，p57단백적양성표체솔분별위90．5％（19／21）、100％（28／28）화0．0％（0／32），PHM화CHM조간유명현차이（P＜0．01）；p53단백적양성표체솔분별위28．3％（5／21）、71．4％（20／28）화87．5％（28／32），HA、PHM조상비야유명현차이（P＜0．01）；p63단백적양성표체솔분별위81．0％（17／21）、89．3％（25／28）화87．5％（28／32），각조간균무통계학차이。결론：이상규석사절편적병리형태특정위기출，결합면역조화검측p57、p53화p63적결과，대감별수종성유산화포도태구유중요개치。
Objective:To investigate the value of p57 , p53 and p63 proteins in distinguishing diagnosis of hydropic abortion (HA), partial hydatidiform mole (PHM) and complete hydatidiform mole (CHM). Methods:Immunohistochemical stains (Envision method) for p57, p53 and p63 were performed in tissue samples of HA (n=21), PHM (n=28) and CHM (n=32). Results:The positive rates of p57 in HA, PHM and CHM were 90.5%(19/21),100%(28/28) and 0%(0/32), respectively. There was a significant difference between PHM and CHM (P<0.01). The positive rates of p53 in HA and PHM were 28.3%(5/21) and 71.4%(20/28) and 87.5%(28/32) respectively, and the difference between them was statistically significant(P<0.01). The p63 expression in HA was less than that in HM (PHM and CHM), and the rates were 81%(17/21) and 89.3%(25/28) and 87.5%(28/32). The expressions were not significantly different between HA and HM. Conclusion: In pathological morphological characteristics as the basis, combined with immunohistochemical detection of p57, P53 and P63, and has important value for distinguishing hydropic abortion and hydatidiform mole.