CAJ | 학술논문

目的：探讨临床药师干预对胸外科手术抗菌药物的应用效果。方法自2013年1月起，本院派临床药师对胸外科围术期抗菌药物应用情况进行干预。随机选取2012年1月~2013年1月在本院胸外科接受手术治疗的200例患者作为对照组，选取2013年2月~2014年2月的200例病例作为干预组。根据抗菌药物合理应用的评价标准，比较两组手术患者抗菌药物应用品种及比例、用药疗程、抗菌药物合理性以及抗菌药物占药品总费用情况。结果与对照组相比，干预组Ⅰ类切口手术预防性应用抗菌药物应用率明显下降，由65.17%降至35.48%，差异有统计学意义(P<0.05)；抗菌药物预防性应用不合理例数由61例(占36.09%)降至23例(占16.43%)，抗菌药物费用占药品总费用的比例由15.56%降至10.59%，降幅为4.97%。结论临床药师干预胸外科手术患者应用抗生素可有效规范预防性应用抗菌药物，提高用药合理性，对减轻患者负担以及减缓和降低细菌耐药性的发生有重大意义。
목적：탐토림상약사간예대흉외과수술항균약물적응용효과。방법자2013년1월기，본원파림상약사대흉외과위술기항균약물응용정황진행간예。수궤선취2012년1월~2013년1월재본원흉외과접수수술치료적200례환자작위대조조，선취2013년2월~2014년2월적200례병례작위간예조。근거항균약물합리응용적평개표준，비교량조수술환자항균약물응용품충급비례、용약료정、항균약물합이성이급항균약물점약품총비용정황。결과여대조조상비，간예조Ⅰ류절구수술예방성응용항균약물응용솔명현하강，유65.17%강지35.48%，차이유통계학의의(P<0.05)；항균약물예방성응용불합리례수유61례(점36.09%)강지23례(점16.43%)，항균약물비용점약품총비용적비례유15.56%강지10.59%，강폭위4.97%。결론림상약사간예흉외과수술환자응용항생소가유효규범예방성응용항균약물，제고용약합이성，대감경환자부담이급감완화강저세균내약성적발생유중대의의。
Objective To explore the effect clinical of pharmacist intervention on the application of antibacterial drugs in thoracic surgery. Methods From January 2013,our hospital dispatched clinical pharmacists to carry out intervention on application of antibacterial drugs during the perioperation thoracic surgery.200 patients who received surgical treatment in the thoracic department in our hospital from January 2012 to January 2013 were randomly selected as control group,and 200 patients receiving thoracic surgery from February 2013 to February 2014 were selected as intervention group.According to the appropriate application evaluating criteria of antibacterial drugs,antibacterial drug application types and proportion,course of drug treatment, rationality of antibacterial drugs and proportion of antibacterial drugs in the total drug expenses was compared between two groups. Results Compared with the control group,application rate of preventive antibacterial drugs in typeⅠincision surgery in the intervention group significantly reduced from 65.17% to 35.48%, the difference was statistically significant (P<0.05).Number of inappropriate cases in the preventive application of antibacterial drugs decreased from 61 cases (36.09%) to 23 cases (16.43%).Proportion of expenses of antibacterial drugs in the total drug expenses reduced from 15.56% to 10.59%,with the degree of reduction of 4.97%. Conclusion Intervention of clinical pharmacists on the application of antibiotics operation patients help effectively standardize preventive antibacterial drugs in thoracic surgery,and improve drug rationality,this plays a significant role in alleviating patients’burden, and slowing down and reducing bacterial resistance.