岭南急诊医学杂志
嶺南急診醫學雜誌
령남급진의학잡지
LINGNAN JOURNAL OF EMERGENCY MEDICINE
2015年
4期
322-324
,共3页
类风湿性关节炎%甲氨蝶呤%环孢素%疗效
類風濕性關節炎%甲氨蝶呤%環孢素%療效
류풍습성관절염%갑안접령%배포소%료효
rheumatoid arthritis%methotrexate%cyclosporine%efficacy
目的：探讨甲氨蝶呤联合环孢素治疗类风湿性关节炎（RA）的临床效果。方法：将2011年10月－2014年10月我院收治的150例RA患者随机分为给予单用甲氨蝶呤治疗的对照组（n＝75）和甲氨蝶呤联合环孢素治疗的实验组（n＝75），比较两组的疗效。结果：实验组的总有效率明显高于对照组（89．3％ vs 70．7％，P＜0．05）；治疗后，两组患者的关节压痛指数、关节肿胀指数、ESR、CRP均较治疗前明显下降，但实验组患者的关节压痛指数、关节肿胀指数明显低于对照组患者（P＜0．05）。结论：甲氨蝶呤联合环孢素治疗RA的疗效明显，且安全性高。
目的：探討甲氨蝶呤聯閤環孢素治療類風濕性關節炎（RA）的臨床效果。方法：將2011年10月－2014年10月我院收治的150例RA患者隨機分為給予單用甲氨蝶呤治療的對照組（n＝75）和甲氨蝶呤聯閤環孢素治療的實驗組（n＝75），比較兩組的療效。結果：實驗組的總有效率明顯高于對照組（89．3％ vs 70．7％，P＜0．05）；治療後，兩組患者的關節壓痛指數、關節腫脹指數、ESR、CRP均較治療前明顯下降，但實驗組患者的關節壓痛指數、關節腫脹指數明顯低于對照組患者（P＜0．05）。結論：甲氨蝶呤聯閤環孢素治療RA的療效明顯，且安全性高。
목적：탐토갑안접령연합배포소치료류풍습성관절염（RA）적림상효과。방법：장2011년10월－2014년10월아원수치적150례RA환자수궤분위급여단용갑안접령치료적대조조（n＝75）화갑안접령연합배포소치료적실험조（n＝75），비교량조적료효。결과：실험조적총유효솔명현고우대조조（89．3％ vs 70．7％，P＜0．05）；치료후，량조환자적관절압통지수、관절종창지수、ESR、CRP균교치료전명현하강，단실험조환자적관절압통지수、관절종창지수명현저우대조조환자（P＜0．05）。결론：갑안접령연합배포소치료RA적료효명현，차안전성고。
Objective:To investigate the clinical effect on patients with rheumatoid arthritis (RA) treated by combination of methotrexate and cyclosporine. Methods:150 patients with RA were randomly divided into control group (n=75) given methotrexate,and experimental group (n=75) given cyclosporine and methotrexate from Oct 2011 to Oct 2014,the clinical effects were compared between the two groups. Results: The total effective rate in experimental group was significantly higher than that in the control group (89.3% vs 70.7%,P<0.05). The joint tenderness index,joint swelling index, ESR and CRP were significantly lower after treatment than before treatment in the both groups. The joint tenderness index and joint swelling index in experimental group were significantly lower than those in the control group after treatment (P<0.05). Conclusion:The clinical effect is obvious and safe for patients with RA treated by methotrexate combined with cyclosporine.
