CAJ | 학술논문

目的：通过对类风湿关节炎（RA）患者促炎因子白细胞介素－1（IL－1）、IL－6、干扰素－γ（IFN－γ）血清水平测定，探讨骨化三醇在RA治疗上的价值。方法：106例RA患者随机分为实验组与对照组，各53例，对照组按照常规治疗，实验组在常规治疗基础上加用骨化三醇；测定两组患者治疗前、治疗4周、8周、12周后IL－1、IL－6、IFN－γ血清水平并进行比较分析。结果：患者治疗前，实验组与对照组的IL－1，、IL－6、IFN－γ血清水平对比无明显差异；与对照组比较，实验组在治疗后3种促炎因子血清水平均有所下降，差异有统计学意义；在治疗12周后，实验组比对照组的各项病情指标改善更为明显，差异有统计学意义。结论：骨化三醇对促炎因子具有抑制作用，可以作为RA患者常规治疗的有效补充。
목적：통과대류풍습관절염（RA）환자촉염인자백세포개소－1（IL－1）、IL－6、간우소－γ（IFN－γ）혈청수평측정，탐토골화삼순재RA치료상적개치。방법：106례RA환자수궤분위실험조여대조조，각53례，대조조안조상규치료，실험조재상규치료기출상가용골화삼순；측정량조환자치료전、치료4주、8주、12주후IL－1、IL－6、IFN－γ혈청수평병진행비교분석。결과：환자치료전，실험조여대조조적IL－1，、IL－6、IFN－γ혈청수평대비무명현차이；여대조조비교，실험조재치료후3충촉염인자혈청수평균유소하강，차이유통계학의의；재치료12주후，실험조비대조조적각항병정지표개선경위명현，차이유통계학의의。결론：골화삼순대촉염인자구유억제작용，가이작위RA환자상규치료적유효보충。
Objective:To detect the proinflammatory cytokine include IL-1、IL-6 and IFN-γ level of patients with rheumatoid arthritis(RA), in order to investigate the effect of calcitriol in treatment of RA. Method:106 patients with RA, which were divide into the experimental group (n=53) and control group (n=53) according to the principle of random. The patients in control group had conventional treatment,the patient in experimental group on the basic of conventional treatment combined with calcitriol. The IL-1、IL-6 and IFN-γ level were detected in patients with RA before received the treatment and 4-week, 8-week, 12-week after received the treatment. Results:The level of IL-1、IL-6 and IFN-γ were no different in experimental group compared with control group before the treatment. The level of IL-1、IL-6 and IFN-γ were less in experimental group than those of control group after the treatment .After 12-week treatment, it proved that the result of each index in experimental group were better than control group. Conclusion:Calcitriol had inhibitory effect on proinflammatory cytokine , and it can be used as an effective supplement to the conventional therapy of patients with RA.