CAJ | 학술논문

目的：探讨某部舰艇长航人员高尿酸血症（ HUA）和肾损伤（ KI）的发病情况及其相关影响因素，为制定相应防治对策提供依据。方法对2013年6－8月体检的356名舰艇部队官兵进行检测，项目包括血尿酸（SUA），血脂[总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（ LDL-C）]，血糖（ FPG），空腹胰岛素（ FINS），肝功能[丙氨酸氨基转移酶（ ALT）、谷氨酰转肽酶（ GGT ）、碱性磷酸酶（ ALP ）、总蛋白（ TP ）、白蛋白（ ALB ）、总胆红素（ TBILI ）、直接胆红素（DBILI）]，肾功能[血肌酐（Scr）、尿素氮（BUN）、肾小球滤过率（eGFR）]和血清铁（SF）。采用双变量分析和多元Logistic回归模型分析，对HUA、KI患者进行患病率及相关因素分析。结果患有HUA和KI的舰员各有221例，患病率为62％，两病皆有的舰员有166例。 SUA在417～467μmol／L的HUA患者比例最高。血清尿酸水平与TG、HDL、TP、TBILI、DBILI、BUN、eGFR具有相关性，SDA水平与TP和eGFR具有显著独立相关性，差异有统计学意义（P＜0．05）。结论舰艇长航人员HUA具有独特的流行病学特点，患病率远高于正常人，这主要与肾功能损害有关，需要早期预防和及时治疗。
목적：탐토모부함정장항인원고뇨산혈증（ HUA）화신손상（ KI）적발병정황급기상관영향인소，위제정상응방치대책제공의거。방법대2013년6－8월체검적356명함정부대관병진행검측，항목포괄혈뇨산（SUA），혈지[총담고순（TC）、삼선감유（TG）、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（ LDL-C）]，혈당（ FPG），공복이도소（ FINS），간공능[병안산안기전이매（ ALT）、곡안선전태매（ GGT ）、감성린산매（ ALP ）、총단백（ TP ）、백단백（ ALB ）、총담홍소（ TBILI ）、직접담홍소（DBILI）]，신공능[혈기항（Scr）、뇨소담（BUN）、신소구려과솔（eGFR）]화혈청철（SF）。채용쌍변량분석화다원Logistic회귀모형분석，대HUA、KI환자진행환병솔급상관인소분석。결과환유HUA화KI적함원각유221례，환병솔위62％，량병개유적함원유166례。 SUA재417～467μmol／L적HUA환자비례최고。혈청뇨산수평여TG、HDL、TP、TBILI、DBILI、BUN、eGFR구유상관성，SDA수평여TP화eGFR구유현저독립상관성，차이유통계학의의（P＜0．05）。결론함정장항인원HUA구유독특적류행병학특점，환병솔원고우정상인，저주요여신공능손해유관，수요조기예방화급시치료。
Objective To explore the morbidity of hyperuricemia ( HUA ) and kidney injury ( KI ) among shipboard personnel of a certain naval unit during prolonged deployment at sea and analysis of related risk factors, so as to provide evidence for the development of related prevention and treatment measures . Methods Medical detections were made on 356 male shipboard personnel , who received physical check-ups from June to August , 2013 in the hospital .The physical check-up items included: serum uric acid ( SUA ) , blood lipids (TC, TG, HDL and LDL), blood sugar(FPG, FINS), hepatic function(ALT, GGT, ALP, TP, ALB, TBILI and DBILI), renal function(Scr, BUN) and serum ferritin (SF).Data were analyzed by bivariate analysis and multivariate logistic regression models , to explore the correlation between HUA , KI and nutritional status and the above data .Results Results indicated that there were respectively 221 cases of HUA and KI , with a morbidity rate of 62% ( 221/356 ) , and there were 166 cases that had both HUA and KI .The HUA patients with SUA levels between 417-467μmol/L had the highest morbidity .Bivariate analysis revealed that SUA was closely associated with the levels of TG , HDL, TP, TBILI, DBILI, BUN, eGFR and BG. Multivariate logistic regression further indicated SUA was uniquely related to TP and eGFR (P <0.05). Conclusions The HUA in the shipboard naval personnel seemed to have its epidemiological features , with the morbidity being much higher than that of the normal people , which might be associated with kidney injury . Measures should be taken for early prevention and timely treatment of the disorder clinically .