CAJ | 학술논문

目的：探讨降钙素原（PCT）在慢性阻塞性肺疾病急性加重期患者抗生素使用中的价值。方法将120例患者按随机数字表法分为对照组与PCT组，各60例。PCT组结合PCT检测结果指导患者应用抗生素，对照组则由医师结合患者病情发展判断是否使用抗菌药物，比较两组患者的抗生素使用时间、住院时间、住院费用、治疗效果。结果 PCT组患者的抗生素使用时间、住院时间均明显短于对照组，住院费用明显少于对照组，差异均有统计学意义（均P＜0.05）；PCT组患者临床治疗总有效率为91.7%，明显高于对照组的75.0%，差异有统计学意义（P＜0.05）。结论 PCT可为慢性阻塞性肺疾病急性加重期患者的病因诊断、分层级监测治疗、预后评估提供依据，为抗菌药物的使用提供参考，减少抗生素的使用强度及降低医疗总费用，具有重要的经济及社会效益。
목적：탐토강개소원（PCT）재만성조새성폐질병급성가중기환자항생소사용중적개치。방법장120례환자안수궤수자표법분위대조조여PCT조，각60례。PCT조결합PCT검측결과지도환자응용항생소，대조조칙유의사결합환자병정발전판단시부사용항균약물，비교량조환자적항생소사용시간、주원시간、주원비용、치료효과。결과 PCT조환자적항생소사용시간、주원시간균명현단우대조조，주원비용명현소우대조조，차이균유통계학의의（균P＜0.05）；PCT조환자림상치료총유효솔위91.7%，명현고우대조조적75.0%，차이유통계학의의（P＜0.05）。결론 PCT가위만성조새성폐질병급성가중기환자적병인진단、분층급감측치료、예후평고제공의거，위항균약물적사용제공삼고，감소항생소적사용강도급강저의료총비용，구유중요적경제급사회효익。
Objective To investigate the procalcitonin(PCT)in patients with the use of antibiotics in exacerbations of value in chronic obstructive pulmonary disease and acute.Methods 120 patients were randomly divided into control group and PCT group,60 cases.PCT group combined with detection of PCT results to guide the use of antibiotics in the patients and control group is physician with the patient's condition to determine whether the use of antibiotics,the antibiotics were compared between the two groups using time,length of hospital stay,cost of hospitalization, treatment effect.Results PCT group of patients with antibiotic use time,length of hospital stay were significantly shorter than that of the control group,cost of hospitalization was significantly less than that of the control group,the difference is statisticaly significant(P<0.05);the PCT group of patients with the clinical total efficiency was 91.7%, significantly higher than the control group 75.0%,the diference is statisticaly significant(P<0.05).Conclusion PCT for chronic obstructive pulmonary disease acute exacerbation period of etiological diagnosis and hierarchical level monitoring <br> treatment and prognosis evaluation basis,for use of antibacterial drugs provide a reference reduce the intensity of use of antibiotics and reduce the total medical costs,has important economic and social benefits.