CAJ | 학술논문

目的：探讨酒石酸托特罗定缓释片联合盐酸坦索罗新治疗经尿道前列腺电切（ TURP）术后膀胱过度活动症（ OAB）的临床疗效及安全性。方法92例TURP术后并发 OAB 患者，根据 OAB症状评分（ OABSS），按轻、中、重度进行配对后随机分为 A、B两组，A 组于拔除尿管后次日联合应用酒石酸托特罗定缓释片（4 mg，1次／d ）及盐酸坦索罗辛（0．2 mg，1次／d ）2周；B 组单独使用盐酸坦索罗辛（0．2 mg，1次／d ）2周，比较拔除尿管后的24h、14d两组患者尿急次数、排尿次数、夜尿次数、急迫性尿失禁次数、平均每次尿量、Qmax及OABSS。观察两组治疗期间的不良反应。结果治疗后 A 组尿急次数、排尿次数、夜尿次数、急迫性尿失禁次数、平均每次尿量、Qmax及 OABSS均有显著改善（ P ＜0．05）。 B组排尿次数、平均每次尿量、Qmax均有显著改善（ P ＜0．05）。 A组尿急次数、夜尿次数、急迫性尿失禁次数及 OABSS改善均优于B组（ P ＜0．01）。 A组和B组在治疗期间不良反应总发生率为28．26％（13／46）和26．09％（12／46），患者均可耐受，未发生严重不良事件。结论酒石酸托特罗定缓释片联合盐酸坦索罗辛治疗 TURP术后 OAB症状安全有效。
목적：탐토주석산탁특라정완석편연합염산탄색라신치료경뇨도전렬선전절（ TURP）술후방광과도활동증（ OAB）적림상료효급안전성。방법92례TURP술후병발 OAB 환자，근거 OAB증상평분（ OABSS），안경、중、중도진행배대후수궤분위 A、B량조，A 조우발제뇨관후차일연합응용주석산탁특라정완석편（4 mg，1차／d ）급염산탄색라신（0．2 mg，1차／d ）2주；B 조단독사용염산탄색라신（0．2 mg，1차／d ）2주，비교발제뇨관후적24h、14d량조환자뇨급차수、배뇨차수、야뇨차수、급박성뇨실금차수、평균매차뇨량、Qmax급OABSS。관찰량조치료기간적불량반응。결과치료후 A 조뇨급차수、배뇨차수、야뇨차수、급박성뇨실금차수、평균매차뇨량、Qmax급 OABSS균유현저개선（ P ＜0．05）。 B조배뇨차수、평균매차뇨량、Qmax균유현저개선（ P ＜0．05）。 A조뇨급차수、야뇨차수、급박성뇨실금차수급 OABSS개선균우우B조（ P ＜0．01）。 A조화B조재치료기간불량반응총발생솔위28．26％（13／46）화26．09％（12／46），환자균가내수，미발생엄중불량사건。결론주석산탁특라정완석편연합염산탄색라신치료 TURP술후 OAB증상안전유효。
Objectives To investigate the clinical effect and safety of Tolterodine Tartrate and Tamsulosin Hydrochloride in the treatment of overactive bladder syndrome ( OAB)after transurethral resection of the prostate ( TURP)M.ethods According to the Overactive Bladder Syndrome Score , 92 cases with OAB after TURP were randomly assigned into group A and group B with 46 cases in each.Patients in group A were treated with Tolterodine Tartrate ( 4 mg, once daily) and Tamsulosin Hydrochloride (0.2mg, once daily) for 2 weeks from the first day after catheter removal.Patients in group B were treated with Tamsulosin Hydrochloride (0.2mg, once daily).The mean urgency episodes, micturition episodes, nocturia, uege incontinence, volume voided per micturition, Qmax and OABSS were recorded on the 14th day after catheter removal.were recorded and evaluated as well.Results The value of mean urgency episodes, micturition episodes, nocturia, uege incontinence,volume voided per micturition, Qmax and OABSS were significantly improved after treatment ( P <0.05 ) in group.A The value of mean micturition episodes, volume voided per micturition and Qmax were also significantly improved after treatment ( P <0.05 ) in group B.While the reduction of mean urgency episodes , nocturia,uege incontinence and OABSS in group A was sig -nificantly greater than those in group B( P <0.01 ).The incidence of treatment related adverse events were 28. 26%(13/46) in group Aand 26.09%(12/46) in group B with no serious adverse event observed.Conclusions It is effective and safe for patients with OAB after TURP to accept the combination therapy with Tolterodine Tar-trate and Tamsulosin Hydrochloride.