CAJ | 학술논문

目的：探讨组织学绒毛膜羊膜炎(histological chorioamnionitis,HC)、胎儿血管炎(fetal vasculitis,FV)及 HC 合并 FV 与新生儿呼吸窘迫综合征(respiratory distress syndrome,RDS)的相关性。方法回顾性分析2009年10月至2013年6月在我院新生儿科住院的胎龄28＋0~31＋6周的347例早产儿的临床资料,根据病理检查结果分为 HC 阳性组和 HC 阴性组,FV 阳性组和 FV 阴性组,HC 阳性组再根据是否合并 FV,分为 FV 阳性组及 FV 阴性组；比较上述各组间 RDS 的发生情况。结果各组间临床资料,包括男性比例,出生胎龄,体重,剖宫产率,产前激素应用比例,其母妊娠期高血压、妊娠期糖尿病及妊娠期胆汁淤积的发生率,经统计学分析差异均无统计学意义(P 〉0.05)；HC 阳性组(145例) RDS 发生率为49.6%(72例),HC 阴性组(202例)RDS 发生率为67.3%(136例),HC 阳性组 RDS 发生率明显低于 HC 阴性组(P 〈0.05)；FV 阳性组(64例)RDS 发生率42.2%(27例),FV 阴性组(283例)RDS 发生率63.3%(179例),FV 阳性组 RDS 发生率明显低于 FV 阴性组(P 〈0.05)；HC 阳性 FV阳性组(64例)RDS 发生率42.2%(27例),HC 阳性 FV 阴性组(81例)RDS 发生率55.6%(45例),两组间 RDS 发生率差异无统计学意义(P ﹦0.11)。结论(1)HC、FV 均可降低早产儿 RDS 的发生率。(2)HC 合并 FV 未进一步降低早产儿 RDS 的发生率。
목적：탐토조직학융모막양막염(histological chorioamnionitis,HC)、태인혈관염(fetal vasculitis,FV)급 HC 합병 FV 여신생인호흡군박종합정(respiratory distress syndrome,RDS)적상관성。방법회고성분석2009년10월지2013년6월재아원신생인과주원적태령28＋0~31＋6주적347례조산인적림상자료,근거병리검사결과분위 HC 양성조화 HC 음성조,FV 양성조화 FV 음성조,HC 양성조재근거시부합병 FV,분위 FV 양성조급 FV 음성조；비교상술각조간 RDS 적발생정황。결과각조간림상자료,포괄남성비례,출생태령,체중,부궁산솔,산전격소응용비례,기모임신기고혈압、임신기당뇨병급임신기담즙어적적발생솔,경통계학분석차이균무통계학의의(P 〉0.05)；HC 양성조(145례) RDS 발생솔위49.6%(72례),HC 음성조(202례)RDS 발생솔위67.3%(136례),HC 양성조 RDS 발생솔명현저우 HC 음성조(P 〈0.05)；FV 양성조(64례)RDS 발생솔42.2%(27례),FV 음성조(283례)RDS 발생솔63.3%(179례),FV 양성조 RDS 발생솔명현저우 FV 음성조(P 〈0.05)；HC 양성 FV양성조(64례)RDS 발생솔42.2%(27례),HC 양성 FV 음성조(81례)RDS 발생솔55.6%(45례),량조간 RDS 발생솔차이무통계학의의(P ﹦0.11)。결론(1)HC、FV 균가강저조산인 RDS 적발생솔。(2)HC 합병 FV 미진일보강저조산인 RDS 적발생솔。
Objective To explore the relationship between histological chorioamnionitis(HC),fetal vasculitis(FV)and the morbidity of neonatal respiratory distress syndrome(RDS).Methods Three hundred and forty-seven cases of infants at the gestational ages of 28 +0 to 31 +6 weeks who were admitted to the Neo-natology Department of our hospital from October 2009 to June 2013 were analyzed retrospectively.They were divided into four groups according to the occurrence of HC and FV,namely,HC positive group and HC negative group,FV positive group and FV negative group.The patients in the HC positive group were further divided into FV positive group and FV negative group according to the occurrence of FV.The morbidity of RDS among above-mentioned groups was compared.Results The clinical characteristics including propor-tion of male,gestational age,birth weight,cesarean delivery,antenatal corticosteroid use,gestational hyperten-sion,gestational diabetes and cholestasis of pregnancy showed no statistically significant difference among all the groups(P 〉0.05).The incidence of RDS in the HC positive group(145 cases)was 49.6%(72 cases), which was significantly lower than that in the HC negative group(67.3%,126 /202,P 〈0.05).The incidence of RDS in FV positive group(64 cases)was 42.2%(27 cases),which was significantly lower than that in FV negative group(63.3%,179 /283,P 〈0.05)In the HC positive group(145 cases),the incidence of RDS in FV positive group (64 cases)was 42.2% (27 cases),and 55.6% (45 cases)in FV negative group (81 cases),which showed no significant difference(P ﹦0.01 ).Conclusion (1 )HC or FV can reduce the incidence rate of RDS in premature infants.(2)HC combined FV cannot furtherly reduce the incidence of RDS.