中国药物评价
中國藥物評價
중국약물평개
Chinese Journal of Drug Evaluation
2015年
3期
155-158
,共4页
王晓莉%孙四海%李凌云%邵洪锦%贾曼%周焕芹
王曉莉%孫四海%李凌雲%邵洪錦%賈曼%週煥芹
왕효리%손사해%리릉운%소홍금%가만%주환근
荆芥%挥发油%工艺研究
荊芥%揮髮油%工藝研究
형개%휘발유%공예연구
Herba schizonepetae%Volatile oil%Process research
目的：采用水蒸气蒸馏法提取荆芥挥发油，优选提取工艺及包合工艺。方法：以挥发油的提取量为考察指标，以加水量、浸泡时间、提取时间作为3个主要的考察因素，通过L9（34）正交试验法优化荆芥挥发油最佳提取工艺。以挥发油与β-环糊精的比例、溶剂用量、时间为考察因素，优选挥发油的包合工艺。结果：最佳提取工艺为饮片加水12倍量，浸泡3 h，提取8 h；最优包合工艺为挥发油与β-环糊精比例为1∶10，加入溶剂量为3倍量，胶体磨碾磨时间为15 min。结论：优选的提取工艺和包合工艺简便、快速、稳定、可行，可作为荆芥挥发油产业化生产工艺。
目的：採用水蒸氣蒸餾法提取荊芥揮髮油，優選提取工藝及包閤工藝。方法：以揮髮油的提取量為攷察指標，以加水量、浸泡時間、提取時間作為3箇主要的攷察因素，通過L9（34）正交試驗法優化荊芥揮髮油最佳提取工藝。以揮髮油與β-環糊精的比例、溶劑用量、時間為攷察因素，優選揮髮油的包閤工藝。結果：最佳提取工藝為飲片加水12倍量，浸泡3 h，提取8 h；最優包閤工藝為揮髮油與β-環糊精比例為1∶10，加入溶劑量為3倍量，膠體磨碾磨時間為15 min。結論：優選的提取工藝和包閤工藝簡便、快速、穩定、可行，可作為荊芥揮髮油產業化生產工藝。
목적：채용수증기증류법제취형개휘발유，우선제취공예급포합공예。방법：이휘발유적제취량위고찰지표，이가수량、침포시간、제취시간작위3개주요적고찰인소，통과L9（34）정교시험법우화형개휘발유최가제취공예。이휘발유여β-배호정적비례、용제용량、시간위고찰인소，우선휘발유적포합공예。결과：최가제취공예위음편가수12배량，침포3 h，제취8 h；최우포합공예위휘발유여β-배호정비례위1∶10，가입용제량위3배량，효체마년마시간위15 min。결론：우선적제취공예화포합공예간편、쾌속、은정、가행，가작위형개휘발유산업화생산공예。
Objective:To extract schizonepeta volatile oil from herba schizonepetae with steam distillation method,optimize the extrac-tion process and inclusion process.Methods:The weight of schizonepeta volatile oil was taken as the observation index,water adding vol-ume,soak time and extraction time were taken as 3 main factors.L9 (34 ) orthogonal test was adopted to optimize the best extraction process.The proportion of β-cyclodextrin and oil, the amount of extraction solvent and time as factors, to optimize the best inclusion process.Results:The best extraction process:12 times of water adding volume,3 h soaking,2 h extraction.The best inclusion process:the proportion of β-cyclodextrin and oil was 1∶10, the amount of solvent was 3 times,grinding time was 15 min.Conclusion:The opti-mum processes are simple,steady and attainable, can be used as industrial production process.
